1989 human bone regeneration. Medical search. Frequent questions

Neuronal survival, axonal regeneration, and ultrastructural changes at ventral spinal cord were also investigated. (hindawi.com)
Regarding axonal regeneration, coaptation allowed recovery of greater number of myelinated fibers, with improved morphometric parameters. (hindawi.com)
Finally, PCAF is necessary for conditioning-dependent axonal regeneration and also singularly promotes regeneration after spinal cord injury. (nature.com)
Thus, we find a specific epigenetic mechanism that regulates axonal regeneration of CNS axons, suggesting novel targets for clinical application. (nature.com)
Identification of a specific regulatory mechanism shared by several essential genes may lead to novel molecular strategies recapitulating the conditioning effect, thus non-surgically enhancing axonal regeneration in the CNS. (nature.com)
Finally, we established that PCAF is required for regeneration following a conditioning lesion and PCAF overexpression promotes axonal regeneration similar to that of a conditioning lesion after CNS injury in spinal ascending sensory fibres. (nature.com)
Our results show the first evidence of immediate retrograde signalling leading to long-term epigenetic reprogramming of gene expression of select genes whose modulation leads to axonal regeneration in the hostile spinal environment. (nature.com)

J Oral Maxillofacial Surg 1989;47:1116-1118. (thejcdp.com)

The Egyptians used images of the tilapia fish as a symbol of rebirth and regeneration. (penn.museum)
Here the M and zig zag appear under the figure's breasts with the butterfly or sacred labrys , signs of rebirth and regeneration. (ritualgoddess.com)

Immunohistochemical studies of antigen localization on cryostat sections of rat calvaria, long bone, and soft tissues demonstrated that five of these MAbs, UBIM 1,2,3,12, and 17, recognize antigens that are restricted to normal rat osteoblasts and chondrocytes. (docksci.com)
HA is located in periodontal tissues in differing amounts, including non‑mineralized tissues, such as gingiva and periodontal ligament, and lower levels located in mineralized tissues, such as cementum and alveolar bone. (spandidos-publications.com)
With these methods, near-infrared energy is primarily absorbed in the superficial tissues, thus these approaches are unable to sufficiently evaluate the biological effects of solar near-infrared that reaches human tissue. (scirp.org)
The dermis offers low resistance, as do almost all internal tissues except bone, which is a poor conductor of electricity. (medscape.com)
GALNS deficiency induces the accumulation of glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate (C6S) in multiple tissues, particularly bone, cartilage, heart valves, and cornea, whereas β-galactosidase deficiency induces the accumulation of only KS in those tissues. (medscape.com)

4) Treating the gingival inflammation in the presence of continuing mobility or jiggling trauma will result in decreased mobility and increased bone density, but no change in attachment level or alveolar bone level. (5y1.org)
Stratified by serum estradiol level, Periodontitis patients with estrogen deficiency had more bleeding on probing and clinical attachment loss, 64 women between the ages 50 and 70 years, Mean alveolar bone level significantly correlated with systemic BMD, Significant correlation between systemic BMD and mandibular basal BMD, Table 2. (iphoneart.com)

Oreffo specialises in skeletal biology, with a focus on the mechanisms that underpin differentiation of skeletal stem cells and bone regeneration. (wikipedia.org)
The term sarcopenia was first proposed in 1989 by Irwin Rosenberg to describe a multifactorial syndrome that occurs with age and results in loss of skeletal muscle mass and function ( 3 , 4 ). (frontiersin.org)
One of the great advantages of tissue engineering of skeletal muscle is that adult skeletal muscle contains many myogenic precursor stem cells, termed "satellite cells", which are involved in the repair and regeneration of skeletal muscle throughout the lifespan. (josam.org)
Skeletal muscles are designed to produce voluntary movement by applying forces to bones and joints via a muscle contraction. (musculoskeletalkey.com)

The addition of pulsed electromagnetic fields to nutritional supplementation for cartilage and bone matrix regeneration in arthritis and other long standing joint / bone issues provides synergistic effects. (earthpulse.net)
Longer duration, regular interval pulsed electromagnetic field (PEMF) exposure at the proper amplitude, pulse shape (waveform) and frequency (HZ) provide reliable bone matrix and cartilage matrix regeneration. (earthpulse.net)
Thus, IGF has great potential to promote the regeneration of articular cartilage after injur y[ 5 ]. (biomedcentral.com)

When evaluated together with studies on systemic changes during fracture healing and marrow regeneration, these findings suggest that marrow aspiration in humans evokes a systemic osteogenic response. (tau.ac.il)
Recently PEMF gained popularity as adjuvant for fracture healing and bone regeneration. (frontiersin.org)
Qualitative and quantitative assessment of bone fragility and fracture healing using conventional radiography and advanced imaging technologies-focus on wrist fracture. (sciendo.com)

The cases were patients with diagnosis of aplastic anemia confirmed through biopsy or bone marrow aspiration, selected through an active search of clinical laboratories, hematology clinics and medical records. (haematologica.org)

Studies into neuronal plasticity were performed in the nineteenth century, when the French biologist Flourens concluded that it was impossible to localize brain functions (Kolb & Whishaw, 1989). (encyclopedia.com)

Similarly to ESWT, the mechanical stimulation obtained using PEMFs may play a role for treatment of tendinopathy and for tendon regeneration, increasing in vitro TGF-β production, as well as scleraxis and collagen I gene expression. (frontiersin.org)
The effects of PDGFB, the candidate cytokine, were examined by using adipose-derived stem cells (ADSCs) and human fetal osteoblast cell line (hFOB1.19) as in vitro mesenchymal cell and preosteoblast models, respectively. (bvsalud.org)
The ability of osteoprogenitor cells to regenerate bone was significantly reduced upon pretreatment with PDGF-BB in vitro. (allenpress.com)
In vitro, these MAbs recognize cell surface antigens present on two additional cell lines, ROS 24/1 and Rat 2 cells, and on the adherent cell population cultured from rat long bone marrow. (docksci.com)

In 2004 he founded the Centre for Human Development, Stem Cells and Regeneration. (wikipedia.org)
Oreffo combined stem cells and degradable plastic to create an artificial bone, which incorporated a honeycomb-like scaffold to allow blood to flow through it. (wikipedia.org)
The flow of blood encourages a patient's own stem cells to attach to the artificial structure, which results in the growth of new bone. (wikipedia.org)
Specifically, he is interested in integrating advanced biomanufacturing techniques, materials/biomaterials, and cell/stem cell techniques to build tissue analogues, and leveraging them to explore the mechanisms underlying diseases and regeneration. (csuohio.edu)
Cells used in bone engineering are the osteoblasts, osteoprogenitor cells, periosteal cells, and stem cells. (allenpress.com)
Daley's research aims to identify mechanisms that underlie blood disorders and cancer, including how stem cells contribute to tissue regeneration and repair, and to improve drug therapies and transplantation for patients with malignant and genetic bone marrow disease. (northwestern.edu)
Notable contributions from his laboratory have included the creation of customized stem cells to treat genetic immune deficiency, the differentiation of germ cells from embryonic stem cells, the generation of disease-specific pluripotent stem cells by directly reprogramming human fibroblasts, and demonstration of the role of the LIN28/let-7 pathway in cancer. (northwestern.edu)
5. Polini A, Pisignano D, Parodi M, Quarto R, Scaglione S. Osteoinduction of human mesenchymal stem cells by bioactive composite scaffolds without supplemental osteogenic growth factors. (sciendo.com)
Bone marrow mesenchymal stem cells secrete factors that exert anti-apoptotic and pro-apoptotic effects on H9c2 cardiac myoblasts. (anl.gov)
The problem is that these human embryonic stem cell lines have been grown in such a way that they are contaminated by animal protein and cannot be used for human therapeutic purposes,' Beck explains. (pharmexec.com)
Human mesenchymal stem cells (MSC) with the capacity to differentiate into osteoblasts provide potential for the development of novel treatment strategies, such as improved healing of large bone defects. (biomedcentral.com)
In this study we asked if human MSC are developing in an aberrant or unwanted way during ex vivo long-term cultivation and if cultivation conditions exert any influence on their stem cell maintenance. (biomedcentral.com)

Clinical human comparison of expanded polytetrafluoroethylene barrier membrane and freeze-dried dura mater allografts for guided tissue regeneration of lost periodontal support. (thejcdp.com)
However, no clear evidence of a clinical value of ESW and PEMF has been found in literature with regards to the treatment of tendinopathy in human, so further clinical trials are needed to confirm the promising hypotheses concerning the effectiveness of ESWT and PEMF mechanical stimulation. (frontiersin.org)
However, their low frequency in bone marrow necessitate ex vivo expansion for further clinical application. (biomedcentral.com)
Among the many different therapeutic approaches, including exercise, hormone, nutritional therapy, and/or a combination thereof, no one approach has emerged as superior in animal or human studies, and the great variability in the clinical outcomes of patients treated with these approaches has prevented identification of the most effective therapy ( 7 , 8 ). (frontiersin.org)

In search of key regulatory mechanisms that may clarify the molecular nature of this regenerative gene expression programme, we hypothesized that as an 'orchestrator of gene regulation' epigenetic changes would direct expression of genes crucial for regeneration only in the presence of pro-regenerative signalling following peripheral but not central damage. (nature.com)

Treatment of intraosseous periodontal defects with a combined adjunctive therapy of citric acid conditioning, bone grafting, and placement of collagenous membranes. (thejcdp.com)
however, we hypothesize that the VSM can be used to deliver osteoblastic progenitors into bone defects. (allenpress.com)
The pretreatment of osteoblastic cells with PDGF-BB before transplantation into osseous defects is investigated in the present study to further investigate the role of this growth factor in bone regeneration. (allenpress.com)
He believed that infrabony pockets were associated with the advancing "plaque front" or apical growth of subgingival plaque and the formation of either horizontal or angular bone defects were dependent on the width of the interproximal bone. (5y1.org)
Teeth with narrow interproximal bone develop horizontal defects while teeth with wide interproximal bone were more likely to develop angular or vertical defects. (5y1.org)

To assess the possible occurrence of a similar phenomenon in humans, serum markers of bone formation, osteocalcin and alkaline phosphatase, were measured in marrow donors before the aspiration of large amounts of iliac marrow and 1 day to 5 weeks thereafter. (tau.ac.il)
8 It stimulates DNA synthesis of rat calvarial cells and increases the production of osteopontin but decreases bone sialoprotein, osteocalcin, alkaline phosphatase activity, and mineralization in bone cells. (allenpress.com)

According to preliminary findings, HA exhibits potential in the regulation of periodontal tissue regeneration and in the treatment of periodontal disease. (spandidos-publications.com)
The diagram highlights the osseous target for periodontal disease (alveolar cortical bone) and osteoporosis (trabecular bone). (iphoneart.com)
Management of patients on bisphosphonate therapy: a bibliographic review looking into a person ' S.... Efficacy of periodontal disease and osteoporosis.2 ) osteoporosis effect on periodontal Wound Healing and Regeneration in an Osteoporotic Model ligature-induced. (iphoneart.com)

PEMF promotes various healing mechanisms, and has been shown in peer reviewed studies to promote bone and connective tissue regeneration, even where degenerative conditions like rheumatoid arthritis exist. (earthpulse.net)
Keystone Symposium, Molecular Mechanisms of Cardiac Disease and Regeneration, February 19-24. (anl.gov)
Despite growing experience and knowledge concerning human MSC and their use in cell-based strategies, the molecular mechanisms that govern MSC self-renewal, expansion and multilineage differentiation are not well understood and remain an active area of investigation. (biomedcentral.com)

4 Although bone marrow transplants have increased the survival rate of patients with AA, most people do not have access to this therapy, and fatality rates of the disease remain high. (haematologica.org)
The present review aimed to examine the role of HA in periodontal therapy, and investigate the current literature supporting its use in periodontal regeneration. (spandidos-publications.com)
24] Hawkins D, Abrahamse H.: Effect of multiple exposures of low-level laser therapy on the cellular responses of human skin fibroblasts. (safelaser.info)

Of these materials, autogenous bone grafts remain the gold standard for bone regeneration. (allenpress.com)
12. Lucaciu Ondine, Soritau Olga, Baciut G, Lucaciu D, Baciut M, Campian R, Bran S. The Role of Bone Morphogenetic Proteins in Tissue Engineering Particulate Bone Grafts. (sciendo.com)
Bone Regeneration in Craniofacial Reconstruction with Particulate Grafts obtained through Tissue Engineering. (sciendo.com)

In this manuscript, we will analyze the rationale of mechanical stimulation by Extracorporeal shock wave (ESW) and Pulsed electromagnetic fields (PEMF) for tendon regeneration, and its possible role in the treatment of different tendinopathies. (frontiersin.org)

Reduce level of estrogen also induce osteocyte apoptosis which disrupt the homeostasis of bone. (iphoneart.com)

Overall, the present data suggest that acute repair of neonatal peripheral nerves with fibrin sealant results in neuroprotection and regeneration of motor and sensory axons. (hindawi.com)

We illustrated for the first time in a human model the three main stages of osteogenic development, and we could show the diverse regulation of the SMAD pathways by TGF-β2 and BMPs. (biomedcentral.com)

Various materials have been used to promote bone regeneration around dental implants, including autografts, allografts, xenografts, and alloplasts. (allenpress.com)

He described two regions in the periodontium: the zone of irritation (marginal and interdental gingiva and gingival and transeptal fibers) and the zone of codestruction (periodontal ligament, alveolar bone, cementum, transeptal and alveolar crest fibers). (5y1.org)

The antigens appear to be localized to the cell surface of the osteoblast, with no apparent staining of bone matrix in either undecalcified or decalcified sections. (docksci.com)
INTRODUCTION HE OSTEOBLAST (OB) is a key cell in bone formation, synthesizing and secreting the organic matrix of bone, and is involved in the regulation of matrix mineralization. (docksci.com)

He was also supervised by Dr. Daniel Chen to bioprint artificial tissue scaffolds for damaged nerve regeneration. (csuohio.edu)

3. Burg Kjl, Porter S, Kellam J. Biomaterial developments for bone tissue engineering. (sciendo.com)

The plasticity of the brain is the basis of cognitive modifiability, which is highly dependent on the amount and quality of interactions with the human environment-ecology-of the individual. (encyclopedia.com)

Interestingly, the lack of regeneration of injured ascending sensory fibres in the spinal cord can be partially enhanced by an injury to the peripheral branch (conditioning lesion) of DRG neurones 7 . (nature.com)

A morphoquantitative comparison of the neurons of the lateral and medial subdivision of the human parabrachial nucleus. (unibs.it)
Importantly, exogenous treatment with neurotrophins transiently rescues a significant number of neurons, leading to the possibility of axonal regrowth and regeneration [ 19 , 20 ]. (hindawi.com)

Relationship between BMD, dental panoramic radiographic findings and biochemical markers of bone turnover in diagnosis of osteoporosis. (iphoneart.com)

To address this question we first developed human oligonucleotide microarrays with 30.000 elements and then performed large-scale expression profiling of long-term expanded MSC and MSC during differentiation into osteoblasts. (biomedcentral.com)

After 16 weeks, animals were sacrificed and defect areas evaluated for bone regeneration. (allenpress.com)
2 , 3 Bone engineering involves the delivery of cells or biologic molecules such as growth factors to a defect site for tissue regeneration. (allenpress.com)

CONCLUSION: PDGFB stimulates the GRB2/ERK/RUNX2 pathway in ADSCs, promotes osteoblastogenesis of ADSCs, and enhances the extracellular matrix of osteoblasts, which may contribute to pathological bone formation in AS. (bvsalud.org)

Due to the smaller osteoconductive capacity when compared to autogenic bone, as well as being osteoinductive and osteogenic, these materials may have different chemical formulations and associations with the strategy of improving performance 6 . (bvsalud.org)

Osteoporosis is a common metabolic bone disease which frequently occurs in postmenopausal women, and occurs less frequently in men. (iphoneart.com)

Here we show through systematic epigenetic studies that the histone acetyltransferase p300/CBP-associated factor (PCAF) promotes acetylation of histone 3 Lys 9 at the promoters of established key regeneration-associated genes following a peripheral but not a central axonal injury. (nature.com)

It has been shown recently in experimental animals that regeneration of bone marrow after ablation is associated with enhanced osteogenic growth factor activity and a systemic increase in bone formation. (tau.ac.il)

Keystone Symposium, Molecular Biology of Cardiac Diseases and Regeneration, April 3-8. (anl.gov)

These aged male rats constitute only the surviving 15% of the original cohort of Wistar rats, and for the purposes of aging research are considered equivalent to human beings of ~90 years of age or older (US Dept. of Health and Human Services, Vital Statistics of the United States, 1994). (josam.org)
Initial changes in alveolar bone volume for sham-operated and ovariectomized rats in ligature-induced experimental periodontitis. (iphoneart.com)
Bone Balance Along the tooth Socket in Rats and are following all recommended infection control processes so that your is! (iphoneart.com)
Structure of Aged Ovariectomized Rats adjacent bone and ligament tooth-supporting alveolar bone loss in Estrogen‐Deficient Rats of natural tooth in. (iphoneart.com)

Therefore, this study evaluated neuroprotection and regeneration after neonatal peripheral nerve coaptation with fibrin sealant. (hindawi.com)

Endometrial ( EN ) and placental ( PL ) morphology and protein synthesis during pregnancy ( PG ) and pseudopregnancy ( PS ) in the cat. (anl.gov)

Daley earned his PhD in biology at MIT in 1989 and his medical degree from Harvard Medical School in 1991. (northwestern.edu)

Oral studies in animals support the human evidence regarding neurobehavioral toxicity of lead to infants and children from prenatal and postnatal exposure. (cdc.gov)
At higher levels of exposure in humans, lead produces cardiac lesions and electrocardiographic abnormalities. (cdc.gov)
Public health officials and others concerned with appropriate actions to take at hazardous waste sites may want information on levels of exposure associated with more subtle effects in humans or animals (LOAELs) or exposure levels below which no adverse effects (NOAELs) have been observed. (cdc.gov)
Estimates of exposure levels posing minimal risk to humans (Minimal Risk Levels or MRLs) have been made for methyl parathion. (cdc.gov)
An MRL is defined as an estimate of daily human exposure to a substance that is likely to be without an appreciable risk of adverse effects (noncarcinogenic) over a specified duration of exposure. (cdc.gov)
As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. (cdc.gov)

Marston W.A. Dermagraft, a bioengineered human dermal equivalent for the treatment of chronic nonhealing diabetic foot ulcer. (genescells.ru)
Many older men and women elderly men with Hypergonadotropic Hypogonadism bones become less dense due to chronic. (iphoneart.com)

After successfully realising artificial bone, Oreffo created the spinout company Renovos, who fabricate new materials for tissue repair. (wikipedia.org)
and (2) repair and regeneration. (musculoskeletalkey.com)

Pulsed electromagnetic field research has proven PEMF's capable of equal or far better results than conventional therapies and invasive procedures like arthroscopic surgery, bone grafting, bone cement, etc., without side effects, pain, expense and risk of complications. (earthpulse.net)

Oreffo completed doctoral research at the University of Oxford, where he investigated Vitamin A and bone. (wikipedia.org)
Here he worked with Gregory Mundy, an expert in bone and mineral research. (wikipedia.org)
He returned to the United Kingdom in 1989, where he joined Zeneca as a principal research scientist. (wikipedia.org)
In 1999, Oreffo joined the University of Southampton, where he led the Bone and Joint Research Group. (wikipedia.org)
Journal of Bone and Mineral Research. (wikipedia.org)
Journal of Bone and Mineral Research , 4 (4), 643-646. (tau.ac.il)
New research published in Nature Medicine on January 23 highlights yet another challenge: The cell lines currently approved for study under federal funding contain a non-human molecule, the sialic acid Neu5Gc, which elicits an immune response in humans. (pharmexec.com)

Strietzel F.P. Tissue-engineered bone for lateral alveolar ridge augmentation: a case report. (genescells.ru)

Lower the risk but may have a negative effect on low-bone-mass-treatment outcomes loss. (iphoneart.com)

Anatomy41

Organisms12

Diseases18

Chemicals and Drugs56

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Phenomena and Processes35

Disciplines and Occupations2

Technology, Industry, Agriculture22

Axonal regeneration7

Surg1

Rebirth and regeneration2

Tissues5

Alveolar bone level2

Skeletal4

Cartilage3

Fracture3

Marrow aspiration1

Neuronal1

Vitro4

Stem12

Clinical4

Regenerative1

Defects5

Alkaline phosphatase2

Periodontal disease3

Mechanisms3

Therapy3

Grafts3

Electromagnetic fields1

Homeostasis1

Axons1

Pathways1

Dental implants1

Cementum1

Osteoblast2

Scaffolds1

Tissue Engineering1

Dependent1

Sensory1

Neurons2

Findings1

Differentiation1

Defect2

Osteoblasts1

Osteoinductive1

Occurs1

Promotes1

Osteogenic1

Diseases1

Rats4

Nerve1

Morphology1

Biology1

Exposure6

Chronic2

Repair2

Therapies1

Research7

Lateral1

Outcomes1