Immunohistocytochemical examination of the skin reveals characteristic abnormalities in the structure of lamellar granules and in the expression of epidermal keratin. (medscape.com)
Knuckle pads, in an epidermal palmoplantar keratoderma patient with Keratin 9 R163W transgrediens expression. (medscape.com)
In addition, the gene that encodes psoriasin is positioned within the epidermal differentiation complex (EDC) (10-12), a gene cluster that contains several genes of importance in the terminal differentiation of the human epidermis (10, 11). (medicaljournals.se)
Differentiation3
Architectural organization of filiform papillae in normal and black hairy tongue epithelium: dissection of differentiation pathways in a complex human epithelium according to their patterns of keratin expression. (bmj.com)
while only two microcystic adnexal carcinoma cases (15%) and one squamous cell carcinoma with ductal differentiation (12%) expressed CK7 in the remaining three tumor categories. (dadospdf.com)
SM-AP1-3 cells were immunopositive for keratin only, indicating their duct-epithelial or squamous cell differentiation, while SM-AP4/5 cells were positive for both keratin and S-100 protein, indicating their myoepithelial cell differentiation. (biomedcentral.com)
Elastin3
These include keratin, collagen, and elastin, which often serve a common mechanical function in structural support of cells and tissues. (imechanica.org)
The health and appearance of our skin, hair and nails depends on the health of several structural proteins they share, namely collagen, keratin and elastin. (lifeextension.com)
The appearance and integrity of our skin, hair, and nails are dependent upon a framework of structural proteins, especially keratin, collagen, and elastin. (lifeextension.com)
Fortunately, lifestyle changes and targeted nutritional interventions-particularly collagen peptides, solubilized keratin, and Polypodium leucotomos extract-can support skin, hair and nails from the inside out. (lifeextension.com)
Protein2
Keratin, type I cytoskeletal 19 also known as cytokeratin-19 (CK-19) or keratin-19 (K19) is a 40 kDa protein that in humans is encoded by the KRT19 gene. (wikipedia.org)
Here we investigated the role of IPO13 in the pathogenesis of pterygium and the underlying mechanism including interaction with other cell proliferation-related factors: keratin 17 (K17), a lesional protein and a member of the type I keratins, and c-Jun, a protein of the activator protein-1 complex. (molvis.org)
Patients aged2
It is indicated for metastatic MCC in adults and pediatric patients aged 12 years or older. (medscape.com)
Ear pain of otitis externae is more commonly observed among patients aged 7-12 years old. (wikidoc.org)
Tumor1
Keratin 19 is often used together with keratin 8 and keratin 18 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood. (wikipedia.org)
Gene1
Mutations in ABCA12 , a gene that encodes adenosine triphosphate (ATP)-binding cassette transporter (ABC), subfamily A, member 12, in chromosome region 2q35, underlie this disorder. (medscape.com)
Secondary1
His later secondary education (years 11 and 12) was at St. Patrick's College, Ballarat (1940-41). (csiropedia.csiro.au)
Years1
In 2017, avelumab became the first drug approved by the FDA for metastatic Merkel cell carcinoma in adults and children aged 12 years or older. (medscape.com)
Member1
Keratin 19 is a member of the keratin family. (wikipedia.org)
Skin3
[ 1 ] Harlequin ichthyosis is characterized by a profound thickening of the keratin layer in fetal skin. (medscape.com)
Oral ingestion of solubilized keratin plus vitamins and minerals significantly improved various aspects of skin appearance, decreased hair loss, and increased nail strength. (lifeextension.com)
The possible mechanisms by which exhaled NO levels are reduced in smoking subjects are a potential negative feedback mechanism of the NO from the cigarette smoke, which could lead to downregulation of NO synthase (NOS) in the lungs 8 , 9 , an inadequate supply of cofactors necessary for NO production, such as tetrahydrobiopterin 10 , and an increase in the breakdown of NO 11 , 12 . (ersjournals.com)
He also served as officer-in-Charge of the Parkville site during the very stressful year 1988 during the break-up of the original Division. (csiropedia.csiro.au)
Inches1
Though a humpback whale mouth can get up to 10 feet , its throat can only stretch out to around 12-15 inches in diameter , making it impossible to feed on very large meals. (centerforsurfresearch.org)