• anti-HIV drugs
  • Additionally, as with many common health foods / nutritional supplements / natural remedies (such as grapefruit juice, aloe vera, borage oil, DHEA, ginko, St John's wort, milk thistle and valerian), there is a theoretical risk of an adverse interaction between anti-HIV drugs and licorice (liquorice). (answers.com)
  • novel
  • When tested, the YBF380 variant reacted with an envelope antigen from SIVcpz rather than with those of Group M or Group O, indicating it was indeed a novel strain of HIV-1. (wikipedia.org)
  • Therefore, novel anti-HIV agents exhibiting distinct resistance patterns, and favorable pharmacokinetic as well as safety profiles are needed to provide more treatment options. (allindianpatents.com)
  • drugs
  • These drugs prevent proteolytic cleavage of HIV Gag and Pol polyproteins that include essential structural and enzymatic components of the virus. (wikipedia.org)
  • These nanotechnology carriers are able to deliver the HIV current drugs in a controlled and/or targeted manner thereby increasing the drug bioavailability and residence time at target sites with a considerable improvement in life quality of HIV patients. (annexpublishers.co)
  • As per WHO, HIV treatments include us … e of at least three antiretroviral drugs to suppress the HIV virus. (answers.com)
  • The drugs bevirimat and vivecon are being investigated for their benefits in HIV treatment. (answers.com)
  • An overview of the current state of the HIV drugs has been published (De Clercq, reference 101). (allindianpatents.com)
  • Using state-of-the-art drug design methods, his team's main goal is to identify new antiviral drugs effective against viral cell entry and assembly of human immunodeficiency virus type 1 (HIV-1). (researchfeatures.com)
  • BRD4 is a major target of BET inhibitors, a class of pharmaceutical drugs currently being evaluated in clinical trials. (wikipedia.org)
  • replication
  • There are several steps in the HIV life cycle that may be interfered with, thus stopping the replication of the virus. (wikipedia.org)
  • contacting HIV-1 infected human cells with an effective HIV-1 replication inhibiting amount of chloroquine or a pharmaceutically acceptable salt thereof. (google.ca)
  • human immun
  • Human immunodeficiency virus (HIV) is a lentivirus that has two major species, HIV-1 which causes the majority of the epidemic, and HIV-2, a close relative whose distribution is concentrated in western Africa. (wikipedia.org)
  • Genome organization of FIV and clinical characteristics of the disease caused by the virus are similar to those of human immunodeficiency virus (HIV). (mdpi.com)
  • HIV commonly stands for human immunodeficiency virus. (answers.com)
  • 3. The method of claim 1, wherein the cell-penetrating peptide is a human immunodeficiency virus (HIV) trans-activator of transcription (TAT) cell-penetrating peptide. (freepatentsonline.com)
  • The present invention is concerned with methods of inhibiting the infectivity of Human Immunodeficiency Virus-1 (HIV-1) in human cells infected therewith. (google.ca)
  • entry
  • Studies of Stein et al (18) have shown that HIV entry into T cells by the CD4 receptor-mediated endocytosis is pH-independent and not inhibited by weak bases. (google.ca)
  • We applied an innovative experimental model using primary and immortalized human cervical and vaginal epithelial cells to assess the functional properties of Lactobacillus jensenii , a predominant constituent of the healthy vaginal microbiome, engineered to express the HIV-1 entry inhibitor modified cyanovirin-N (mCV-N). In this model bacteria colonize the epithelial cells over a period of 24-72 h. (beds.ac.uk)
  • Gels may not efficiently cover the entire genital tract mucosal surface vulnerable to HIV entry. (beds.ac.uk)
  • Therefore
  • They have therefore been working on small inhibitory molecules targeted at this site and have identified several promising candidates suitable for further drug development leading to a new class of anti-HIV therapeutics. (researchfeatures.com)
  • effective
  • 1. A method of treating a subject for a tauopathy, the method comprising administering to the subject a therapeutically effective amount of a fusion protein comprising a cell-penetrating peptide linked to a CagA peptide or polypeptide inhibitor of microtubule affinity-regulating kinase (MARK). (freepatentsonline.com)
  • virus
  • More advanced HIV tests have now been developed to detect both Group O and Group N. In 2009, a newly analyzed HIV sequence was reported to have greater similarity to a simian immunodeficiency virus recently discovered in wild gorillas (SIVgor) than to SIVs from chimpanzees (SIVcpz). (wikipedia.org)
  • activity
  • 5. The method of claim 1, wherein the fusion protein comprises an amino acid sequence having at least 95% identity to the sequence of SEQ ID NO: 10, wherein the fusion protein is capable of entering brain cells and inhibiting the activity of MARK. (freepatentsonline.com)
  • The bioengineered lactobacilli expressed mCV-N with anti-HIV activity preserved in the epithelial cell context and caused no significant immunoinflammatory changes as compared to the WT L. jensenii . (beds.ac.uk)
  • major
  • HIV can be divided into two major types, HIV type 1 (HIV-1) and HIV type 2 (HIV-2). (wikipedia.org)
  • Scientists divide HIV-1 into a major group (Group M) and two or more minor groups, namely Group N, O and possibly a group P. Each group is believed to represent an independent transmission of SIV into humans (but subtypes within a group are not). (wikipedia.org)
  • cells
  • Interestingly, the rate of CD4 T cell decline is discordant with low level of productively infected cells in HIV-positive individuals. (biomedcentral.com)
  • Methods are disclosed for inhibiting the infectivity of HIV-1 in human cells. (google.ca)
  • 3. The method of claim 1, wherein said compound or pharmaceutically acceptable salt thereof is contacted with said cells by administering said compound to a patient infected with HIV-1. (google.ca)
  • test
  • It is reportedly most common in Cameroon, where a 1997 survey found that about 2% of HIV-positive samples were from Group O. The group caused some concern because it could not be detected by early versions of the HIV-1 test kits. (wikipedia.org)
  • Many test kits for HIV-1 will also detect HIV-2. (wikipedia.org)
  • Do medical test shows HIV? (answers.com)
  • known
  • As of 2010, there are 8 known HIV-2 groups (A to H). Of these, only groups A and B are pandemic. (wikipedia.org)
  • include
  • Adverse reactions to licorice (liquorice) reported amongst HIV-positive people include: low potassium levels, muscle weakness and soreness, high blood pressure and fluid retention. (answers.com)
  • possible
  • A total of 39 ORFs are found in all six possible reading frames (RFs) of HIV-1 complete genome sequence, but only a few of them are functional. (wikipedia.org)
  • disease
  • In particular, the invention relates to methods of treating Alzheimer's disease and other tauopathies with inhibitors of microtubule affinity regulating kinase (MARK). (freepatentsonline.com)