• 1988
  • Andorn AC, Carlson MA, Gilkeson RC (1988) Specific [ 3 H]UK 14304 binding in human cortex occurs at multiple high affinity states with alpha 2 -adrenergic selectivity and differing affinities for GTP. (springer.com)
  • inhibition
  • Albert, P. R. and Raquidan, D. (1995) Dopamine-D2 receptor routing through multiple G proteins for inhibition of TRH-stimulated prolactin secretion Endocrine Society Mtg. (springer.com)
  • 7 Consequently, the reduction in 5-HT cell firing by risperidone appears to be related to increased availability of 5-HT in the somatodendritic region of the neurones leading to an enhanced 5-HT 1A autoreceptor activation and, in turn, to inhibition of firing, and is probably only to a minor extent caused by its α 1 -adrenoceptor antagonistic action. (wiley.com)
  • 1992
  • The release of 5-HT is known to be regulated by different populations of autoreceptors: both the somatodendritic 5-HT 1A and terminal 5-HT 1B/1D autoreceptors (for review, see Hen, 1992 ). (aspetjournals.org)
  • presynaptic
  • Thus, the most commonly prescribed antidepressants directly elevate 5-HT (e.g., citalopram), NE (e.g., desipramine), or both (e.g., venlafaxine or mirtazapine) by blocking their transporters or by blocking presynaptic receptors that regulate the release of 5-HT and NE (mirtazapine) ( Richelson, 2003 ). (aspetjournals.org)
  • neurotransmitters
  • 5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. (wikipedia.org)
  • Dopamine (DA), noradrenaline (NE), and serotonin (5-HT) are the three major monoamine neurotransmitters that are known to be modulated by exercise. (mdpi.com)
  • Taste receptor cells (TRCs) express multiple neurotransmitters of unknown function that could potentially participate in a paracrine role. (physiology.org)
  • neurochemical effects
  • Barrett JE, Hoffmann SM, Olmstead SN, Foust MJ, Harrod C, Weissman BA (1989) Behavioral and neurochemical effects of the serotonin (5-HT) 1A receptor ligand spiroxatrine. (springer.com)
  • Frantz K, Hansson K, Stouffer D, Parsons L (2002) 5-HT6 receptor antagonism potentiates the behavioral and neurochemical effects of amphetamine but not cocaine. (springer.com)
  • PMID
  • Journal of Clinical Pharmacology, 30(5):412-21 PMID 2189902 FDA History NDA 018976 FDA notice in the Federal Register. (wikipedia.org)
  • 1986
  • Andorn AC (1986) Do antipsychotic drugs and serotonin down regulate [ 3 H]-spiroperidol binding sites in human cortex? (springer.com)
  • Mita T, Susumu H, Nishino N, Kuno T, Nakai H, Yamadori T, Mizoi Y, Tanaka C (1986) Decreased serotonin S 2 and increased dopamine D 2 receptors in chronic schizophrenics. (springer.com)
  • Cunningham KA, Appel JB (1986) Possible 5-hydroxytryptamine 1 (5-HT 1 ) receptor involvement in the stimulus properties of 1-(m-trifluoromethylphenyl)-piperazine (TFMPP). (springer.com)
  • regulate
  • Approximately 90% of the human body's total serotonin is located in the enterochromaffin cells in the GI tract, where it is used to regulate intestinal movements. (wikipedia.org)
  • Finally, multiple hormonal and neural cues (e.g., leptin, estrogen, and serotonin) that use the melanocortin systems to regulate energy and glucose homeostasis will be reviewed. (pubmedcentralcanada.ca)
  • Current evidence indicates that central melanocortins also regulate insulin sensitivity and glucose homeostasis through distinct CNS populations expressing melanocortin receptors. (pubmedcentralcanada.ca)
  • antipsychotic drugs
  • Thus, the α 1 -adrenoceptor antagonistic action of the antipsychotic drugs might, at least partly, cause the decrease in DRN 5-HT cell firing. (wiley.com)
  • vitro
  • Forster C, Whalley ET (1981) Spiperone contracts the human basilar arterial strip in vitro: possible interaction with 5-hydroxy-tryptamine receptors? (springer.com)
  • An in vitro assay has been used to compare several drugs for their ability to induce synaptosomal serotonin release. (ecstasy.org)
  • Bradberry, C.W., Sprouse, J.S., Aghajanian, G.K. and Roth, R.H. 3,4-Methylenedioxymethamphetamine (MDMA)-Induced Release of Endogenous Serotonin from the Rat Dorsal Raphe Nucleus in vitro: Effects of Fluoxetine and Tryptophan. (ecstasy.org)
  • 1990
  • Coccaro EF, Gabriel S, Siever LJ (1990) Buspirone challenge: preliminary evidence for a role for central 5-HT 1A receptor function in impulsive aggressive behavior in humans. (springer.com)
  • mCPP
  • Other effects of mCPP include nausea, hypoactivity, and penile erection, the latter two the result of increased 5-HT2C activity and the former likely via 5-HT3 stimulation. (wikipedia.org)
  • In comparison studies, mCPP has approximately 10-fold selectivity for the human 5-HT2C receptor over the human 5-HT2A and 5-HT2B receptors (Ki = 3.4 nM vs. 32.1 and 28.8 nM). (wikipedia.org)
  • In accordance with its lack of agonism towards the human 5-HT2A receptor, there are no reports that mCPP produces hallucinogenic effects in humans. (wikipedia.org)
  • citation needed] Analogues of mCPP include: 1-Benzylpiperazine (BZP) 1-Methyl-4-benzylpiperazine (MBZP) 1,4-Dibenzylpiperazine (DBZP) 3-Trifluoromethylphenylpiperazine (TFMPP) 3,4-Methylenedioxy-1-benzylpiperazine (MDBZP) 4-Bromo-2,5-dimethoxy-1-benzylpiperazine (2C-B-BZP) 4-Fluorophenylpiperazine (pFPP) 4-Methoxyphenylpiperazine (MeOPP) Some additional analogues include quipazine, ORG-12962, and 3C-PEP. (wikipedia.org)
  • 1993
  • and fenfluramine, an effective antiobesity drug, increases the release of 5-HT ( Samanin and Garattini, 1993 ). (aspetjournals.org)
  • 2002
  • Messina D et al (2002) Association of the 5-HT6 receptor gene polymorphism C267T with Parkinson's disease. (springer.com)
  • 1994
  • Albert, P R (1994) Heterologous expression of G protein-linked receptors in pituitary and fibroblast cell lines. (springer.com)
  • selectivity
  • Andorn AC, Huang EH, Warren AE (1984) Specific [ 3 H]-spiroperidol binding sites in human prefrontal cortex: potential site multiplicity and overall serotonin-like selectivity. (springer.com)
  • blockade
  • In animals it produces effects including hyperphagia, hyperactivity, and anxiolysis, of which are all likely mediated predominantly or fully by blockade of the 5-HT2C receptor. (wikipedia.org)
  • brain
  • Pedigo NW, Yamamura HI, Nelson DL (1981) Discrimination of multiple [ 3 H]5-hydroxytryptamine binding sites by the neuroleptic spiperone in rat brain. (springer.com)
  • Brain slices of the dorsal raphe nucleus were exposed to a medium containing MDMA and the released serotonin was measured. (ecstasy.org)
  • Lyon, R.A., Glennon, R.A. and Titeler, M. 3,4-Methylenedioxymethamphetamine (MDMA): Stereoselective Interactions at Brain 5- HT1 and 5-HT2 Receptors. (ecstasy.org)
  • Interplay between exercise and monoamines was initially derived from the "Central Fatigue Hypothesis", in which increased brain 5-HT release was found to be associated with central fatigue [ 26 , 27 ]. (mdpi.com)
  • hippocampus
  • Rodents that receive exhaustive treadmill exercise have higher 5-HT in the midbrain, striatum, hypothalamus and hippocampus [ 37 ]. (mdpi.com)
  • synapses
  • Additionally, TRCs expressing the taste-specific G protein gustducin, thought to be important in bitter and sweet transduction cascades, or the T2R family of bitter receptors, are subsets of type II cells ( 1 , 5 , 66 ), cells that lack synapses with the afferent nerve fiber. (physiology.org)
  • bind
  • When the platelets bind to a clot, they release serotonin, where it can serve as a vasoconstrictor and/or a vasodilator while regulating hemostasis and blood clotting. (wikipedia.org)