• rats
  • Treatment of rats with chemical carcinogens, including 2-acetylaminofluorene (2-AAF), leads to a strong increase in the hepatic catecholamine-sensitive adenylate cyclase activity. (aacrjournals.org)
  • We report that hepatocytes isolated from rats which had been fed 2-AAF (0.025% w/w) for 8-12 weeks had an increased number of β-adrenoceptors, as determined by [ 3 H]dihydroalprenolol binding to whole cells and [ 125 I]iodocyanopindolol binding to washed particles. (aacrjournals.org)
  • For both ligands the number of binding sites was about 4-fold higher in hepatocytes from 2-AAF-treated rats than in those from controls. (aacrjournals.org)
  • Oral administration of a diet containing 20% betel-nut powder enhanced the incidences of preneoplastic and neoplastic lesions of the tongue in rats pretreated with 4-nitroquinoline-1-oxide and of preneoplastic liver lesions in rats pretreated with 2-acetylaminofluorene [ref: 2]. (inchem.org)
  • liver
  • However, a similar, albeit short-term, study demonstrated that a comparable dose of L-tryptophan caused liver damage in animals whose metabolism of tryptophan had not been tampered with (Trulson & Sampson, 1986). (supplements-and-health.com)
  • lesions
  • Structural basis for the recognition of diastereomeric 5',8-cyclo-2'-deoxypurine lesions by the human nucleotide excision repair system. (nyu.edu)
  • Cancer
  • 2 Research fellow of The Norwegian Cancer Society. (aacrjournals.org)
  • On the basis of this observation, Pott, with remarkable insight, concluded (1) that the occupation of these men as young boys was directly and causally related to their malignant disease and (2) that the large amounts of soot to which they were exposed was the causative agent of the cancer. (damasgate.com)
  • specific
  • Fibromyalgia (FM) is a common disorder characterized by chronic widespread pain along the body, especially prevalent in women [ 1 , 2 ].Beyond the pain as cardinal symptom in specific anatomical sites, FM patients complain of other debilitating conditions such as fatigue, anxiety, depression, and sleep disturbances [ 3 , 4 ]. (hindawi.com)
  • increase
  • The adenylate cyclase activity of the carcinogen-fed animals showed both a general increase manifested in the basal level (2-fold) and in the activities obtained by stimulation with guanine nucleotides (2-3-fold), cholera toxin (1.5-fold), and glucagon (1.3-fold) and a selective, larger increase in the β-adrenoceptor-linked activity (7-fold increment of the isoproterenol-sensitive activity). (aacrjournals.org)