• rats
  • Treatment of rats with chemical carcinogens, including 2-acetylaminofluorene (2-AAF), leads to a strong increase in the hepatic catecholamine-sensitive adenylate cyclase activity. (aacrjournals.org)
  • We report that hepatocytes isolated from rats which had been fed 2-AAF (0.025% w/w) for 8-12 weeks had an increased number of β-adrenoceptors, as determined by [ 3 H]dihydroalprenolol binding to whole cells and [ 125 I]iodocyanopindolol binding to washed particles. (aacrjournals.org)
  • For both ligands the number of binding sites was about 4-fold higher in hepatocytes from 2-AAF-treated rats than in those from controls. (aacrjournals.org)
  • Oral administration of a diet containing 20% betel-nut powder enhanced the incidences of preneoplastic and neoplastic lesions of the tongue in rats pretreated with 4-nitroquinoline-1-oxide and of preneoplastic liver lesions in rats pretreated with 2-acetylaminofluorene [ref: 2]. (inchem.org)
  • adducts
  • The individual adducts TAM-dG and ( Z )-α-( N 2 -deoxyguanosinyl)tamoxifen and the individual compounds TAM and 4-OH-TAM gave DELFIA 50% inhibitions at 828, 2229, 5440, and 8250 fmol, respectively. (aacrjournals.org)
  • Effect of acetylated and deacetylated 2-aminofluorene adducts on in vitro DNA synthesis. (springer.com)
  • Effect of culture conditions, cell type, and species of origin on the distribution of acetylated and deacetylated deoxyguanosine C)8 adducts of CCNDD-acetoxy-2-acetylaminofluorene. (springer.com)
  • liver
  • However, a similar, albeit short-term, study demonstrated that a comparable dose of L-tryptophan caused liver damage in animals whose metabolism of tryptophan had not been tampered with (Trulson & Sampson, 1986). (supplements-and-health.com)
  • Cancer
  • 2 Research fellow of The Norwegian Cancer Society. (aacrjournals.org)
  • Therefore, the objective of this study was to evaluate the therapeutic efficacy of a combination of non-toxic, low dose of 5-aza 2′ dC with EGCG, on growth inhibition of breast cancer cells. (springer.com)
  • Human breast cancer cell lines (MCF-7, MDA-MB 231) and non-tumorigenic MCF-10A breast epithelial cells were treated with either 5-aza 2′ dC, EGCG, or their combination for 7 days. (springer.com)
  • The results revealed significantly greater inhibition of growth of breast cancer cells by co-treatment with 5-aza 2′ dC and EGCG compared to individual treatments, whereas it has no significant toxicity to MCF-10A cells. (springer.com)
  • On the basis of this observation, Pott, with remarkable insight, concluded (1) that the occupation of these men as young boys was directly and causally related to their malignant disease and (2) that the large amounts of soot to which they were exposed was the causative agent of the cancer. (damasgate.com)
  • lesions
  • Structural basis for the recognition of diastereomeric 5',8-cyclo-2'-deoxypurine lesions by the human nucleotide excision repair system. (nyu.edu)
  • adduct
  • For the immunogen TAM-DNA, 50% inhibition was at 2.0 ± 0.11 (mean ± SE, n = 18) fmol of ( E )-α-( N 2 -deoxyguanosinyl)tamoxifen (TAM-dG) adduct in TAM-DNA by DELFIA. (aacrjournals.org)
  • rise
  • For instance, internal/biologically effective dose markers can reflect the concrete/integrated exposure to carcinogens, or biological response markers can represent the event, which give rise to carcinogenesis both before and after the agent is administered. (aacrjournals.org)
  • increase
  • The adenylate cyclase activity of the carcinogen-fed animals showed both a general increase manifested in the basal level (2-fold) and in the activities obtained by stimulation with guanine nucleotides (2-3-fold), cholera toxin (1.5-fold), and glucagon (1.3-fold) and a selective, larger increase in the β-adrenoceptor-linked activity (7-fold increment of the isoproterenol-sensitive activity). (aacrjournals.org)