Loading...
  • rats
  • Treatment of rats with chemical carcinogens, including 2-acetylaminofluorene (2-AAF), leads to a strong increase in the hepatic catecholamine-sensitive adenylate cyclase activity. (aacrjournals.org)
  • We report that hepatocytes isolated from rats which had been fed 2-AAF (0.025% w/w) for 8-12 weeks had an increased number of β-adrenoceptors, as determined by [ 3 H]dihydroalprenolol binding to whole cells and [ 125 I]iodocyanopindolol binding to washed particles. (aacrjournals.org)
  • For both ligands the number of binding sites was about 4-fold higher in hepatocytes from 2-AAF-treated rats than in those from controls. (aacrjournals.org)
  • C. F. Cesarone, M. Romano, D. Serra, L. Scarabelli and S. De Flora, Effects of aminothiols in 2-acetylaminofluorene-treated rats. (springer.com)
  • Oral administration of a diet containing 20% betel-nut powder enhanced the incidences of preneoplastic and neoplastic lesions of the tongue in rats pretreated with 4-nitroquinoline-1-oxide and of preneoplastic liver lesions in rats pretreated with 2-acetylaminofluorene [ref: 2]. (inchem.org)
  • Inhibition
  • For the immunogen TAM-DNA, 50% inhibition was at 2.0 ± 0.11 (mean ± SE, n = 18) fmol of ( E )-α-( N 2 -deoxyguanosinyl)tamoxifen (TAM-dG) adduct in TAM-DNA by DELFIA. (aacrjournals.org)
  • R. A. Andersen, M. Enomoto, E. C. Miller and J. A. Miller, Carcinogenesis and inhibition of the Walker 256 tumor in the rat by trans-4-acetylaminostilbene, its N-hydroxy metabolite, and related compounds, Cancer Res. (springer.com)
  • Therefore, the objective of this study was to evaluate the therapeutic efficacy of a combination of non-toxic, low dose of 5-aza 2′ dC with EGCG, on growth inhibition of breast cancer cells. (springer.com)
  • The results revealed significantly greater inhibition of growth of breast cancer cells by co-treatment with 5-aza 2′ dC and EGCG compared to individual treatments, whereas it has no significant toxicity to MCF-10A cells. (springer.com)
  • Findings of this study suggest that potentiation of growth inhibition of breast cancer cells by 5-aza 2′ dC and EGCG combination treatment, at least in part, is mediated by epigenetic mechanism. (springer.com)
  • vivo
  • C. F. Cesarone, L. Scarabelli and M. Orunesu, Effect of glutathione on alterations of liver DNA structure and metabolic activities induced in vivo by 2-acetylaminofluorene, Anticancer Res. (springer.com)
  • J. D. Scribner and G. Koponen, Binding of the carcinogen 2-acetamidophenanthrene to rat liver nucleic acids: lack of correlation with carcinogenic activity, and failure of the hydroxamic acid ester model for in vivo activation, Chem-Biol. (springer.com)
  • adducts
  • The individual adducts TAM-dG and ( Z )-α-( N 2 -deoxyguanosinyl)tamoxifen and the individual compounds TAM and 4-OH-TAM gave DELFIA 50% inhibitions at 828, 2229, 5440, and 8250 fmol, respectively. (aacrjournals.org)
  • Effect of acetylated and deacetylated 2-aminofluorene adducts on in vitro DNA synthesis. (springer.com)
  • Effect of culture conditions, cell type, and species of origin on the distribution of acetylated and deacetylated deoxyguanosine C)8 adducts of CCNDD-acetoxy-2-acetylaminofluorene. (springer.com)
  • 1990
  • Koenig & Andreesen, 1990) of the furan ring may yield reactive intermediates (e.g. furfural-2,3-epoxide, acetylacrolein, and alpha-ketoglutaric acid) which readily undergo decarboxylation. (inchem.org)
  • tumors
  • Kuchlbauer, J., W. Romen, and H.G. Neumann (1985) Syncarcinogenic effects on the initiation of rat liver tumors by trans-4-acetylaminostilbene and 2-acetylaminofluorene. (springer.com)
  • Although the basic principle has been confirmed in many instances, the correlations of genotoxic effects of aromatic amines with tumor formation, particularly with tissue-specific tumors were not satisfactory 2 . (springer.com)
  • carcinogen
  • The adenylate cyclase activity of the carcinogen-fed animals showed both a general increase manifested in the basal level (2-fold) and in the activities obtained by stimulation with guanine nucleotides (2-3-fold), cholera toxin (1.5-fold), and glucagon (1.3-fold) and a selective, larger increase in the β-adrenoceptor-linked activity (7-fold increment of the isoproterenol-sensitive activity). (aacrjournals.org)
  • Absorption
  • 2. BIOLOGICAL DATA 2.1 Biochemical aspects 2.1.1 Absorption, distribution, biotransformation, and excretion Laboratory animals Furfural is well absorbed after administration by any route. (inchem.org)
  • dietary
  • T. Kitagawa, H. C. Pitot, E. C. Miller and J. A. Miller, Promotion by dietary phenobarbital of hepatocarcinogenesis by 2-methyl-N, N-dimethyl-4-aminoazobenzene in the rat, Cancer Res. (springer.com)
  • Cancer
  • 2 Research fellow of The Norwegian Cancer Society. (aacrjournals.org)
  • Human breast cancer cell lines (MCF-7, MDA-MB 231) and non-tumorigenic MCF-10A breast epithelial cells were treated with either 5-aza 2′ dC, EGCG, or their combination for 7 days. (springer.com)
  • lesions
  • Structural basis for the recognition of diastereomeric 5',8-cyclo-2'-deoxypurine lesions by the human nucleotide excision repair system. (nyu.edu)
  • adduct
  • R. Franz and H.-G. Neumann, Reaction of trans-4-N-acetoxy-N-acetyl-aminostilbene with guanosine, deoxyguanosine, RNA and DNA in vitro: predominant product is a cyclic N 2 , N3-guanine adduct, Chem-Biol. (springer.com)
  • Reaction
  • In animals, the condensation reaction of 2-furoyl CoA with acetyl CoA to yield furanacryloyl CoA is reversible, favouring formation of 2-furoyl CoA (Parkash & Caldwell, 1994). (inchem.org)
  • rise
  • For instance, internal/biologically effective dose markers can reflect the concrete/integrated exposure to carcinogens, or biological response markers can represent the event, which give rise to carcinogenesis both before and after the agent is administered. (aacrjournals.org)
  • liver
  • Hepatocellular carcinoma (HCC) accounts for about 80%-90% of all liver cancers and is the fifth most common cause of cancer mortality [ 1 , 2 ]. (hindawi.com)
  • Kuchlbauer, J., W. Romen, and H.G. Neumann (1985) Syncarcinogenic effects on the initiation of rat liver tumors by trans-4-acetylaminostilbene and 2-acetylaminofluorene. (springer.com)
  • epithelial
  • Human breast cancer cell lines (MCF-7, MDA-MB 231) and non-tumorigenic MCF-10A breast epithelial cells were treated with either 5-aza 2′ dC, EGCG, or their combination for 7 days. (springer.com)
  • 1994
  • In animals, the condensation reaction of 2-furoyl CoA with acetyl CoA to yield furanacryloyl CoA is reversible, favouring formation of 2-furoyl CoA (Parkash & Caldwell, 1994). (inchem.org)
  • chronic
  • Fibromyalgia (FM) is a common disorder characterized by chronic widespread pain along the body, especially prevalent in women [ 1 , 2 ].Beyond the pain as cardinal symptom in specific anatomical sites, FM patients complain of other debilitating conditions such as fatigue, anxiety, depression, and sleep disturbances [ 3 , 4 ]. (hindawi.com)
  • Cell
  • In this connection, many lines of evidence have demonstrated a close relationship between carcinogenesis and cell cycle regulation. (hindawi.com)
  • human
  • Structural basis for the recognition of diastereomeric 5',8-cyclo-2'-deoxypurine lesions by the human nucleotide excision repair system. (nyu.edu)
  • animals
  • The adenylate cyclase activity of the carcinogen-fed animals showed both a general increase manifested in the basal level (2-fold) and in the activities obtained by stimulation with guanine nucleotides (2-3-fold), cholera toxin (1.5-fold), and glucagon (1.3-fold) and a selective, larger increase in the β-adrenoceptor-linked activity (7-fold increment of the isoproterenol-sensitive activity). (aacrjournals.org)
  • light
  • When exposed to UV light, amitrole breaks down to form CO 2 , urea and cyanamide. (inchem.org)
  • form
  • Oxidation yields furoic acid, which, as the coenzyme A (CoA) thioester, is either conjugated with glycine and excreted or condensed with acetyl CoA to form the chain-lengthened metabolite 2-furanacryloyl CoA (Figure 1). (inchem.org)