• As with many targeted agents used to treat solid tumors, it is likely that c-Met/RON inhibitors will have greater benefit when used in combination with chemotherapy or other targeted agents. (oncotarget.com)
  • To assess the safety of anti-tumor necrosis factor (TNF)-alpha therapy in patients with rheumatic disease and chronic Hepatitis B virus (HBV) infection. (koreamed.org)
  • Infections and anti-tumor necrosis factor alpha therapy. (koreamed.org)
  • In previous studies, Tanapoxvirus (TPV) recombinants expressing mouse interleukin-2 (mIL-2) and another expressing bacterial flagellin from Salmonella typhimurium (FliC) have demonstrated anti-tumor efficacy in nude mouse models. (bvsalud.org)
  • A second experiment used TPV/Δ66R/mIL-2 to test whether TPV could be administered intravenously (IV), intramuscularly (IM), or both routes simultaneously to exert similar anti-tumor effects in an indirectly treated tumor. (bvsalud.org)
  • E1 is similar to COOH-terminal domain of the Simian virus 40, plays a role in viral DNA replication maintaining plasmids within a cell. (wikipedia.org)
  • In adults, MCV is typically an asymptomatic, common, and commensal viral infection that initiates rare cancers after virus (rather than host cell) mutations. (cdc.gov)
  • Prophylactic or early intervention strategies with anti-viral agent and regular monitoring of aminotransferases and viral load are needed for patient with evidence of chronic HBV infection. (koreamed.org)
  • Noncytolytic control of viral infections by the innate and adaptive immune response. (koreamed.org)
  • Tumor necrosis factor (TNF)-alpha and TNF receptors in viral pathogenesis. (koreamed.org)
  • Unlikle-most viral illnesses, however, infection with adenovirus (ADV) is often characterized by high fever of long duration, leukocytosis with neutrophilia and elevated peripheral blood inflammatory indices. (webmedcentral.com)
  • In order to determine the degree and frequency of inflammatory marker elevation with ADV Infection, we monitored blood levels of C-reactive protein (CRP) and IL-6 in children with viral symptoms.Children with provend influenza and other nonspecific viral respiratory infections served as controls. (webmedcentral.com)
  • Ultimately, the goal of our study was to evaluate the diagnostic relevance of CRP and IL-6 for ADV infection in a pediatric setting compared with influenza and non-ADV viral illness. (webmedcentral.com)
  • Viral infection. (hearingreview.com)
  • Twenty eight percent of patients who present with a sensorineural hearing loss will report a viral-like upper respiratory infection within 1 month before the onset of their hearing loss. (hearingreview.com)
  • For most serotypes, adenovirus infection is mediated by the high-affinity binding of the fiber-knob region to a receptor of target cell, named as the coxsackie-Ad receptor (CAR), which mainly determines the viral tropism [44]. (genemedi.com)
  • Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis, cancer, and liver failure. (wjgnet.com)
  • The role of tumor necrosis factor alpha blockers in scleroderma cases temporally associated with CMV infection requires further evaluation. (digitalnaturopath.com)
  • Lack of tumor necrosis factor alpha induces impaired proliferation of hepatitis B virus-specific cytotoxic T lymphocytes. (koreamed.org)
  • Intracranial Germ Cell Tumors (iGCTs) are rare brain tumors that originate from embryonic germ cells. (researchsquare.com)
  • Therefore the application of immunotherapy has driven the treatment of brain tumors to the study of the response of intratumoral and systemic immune cells and cytokines to these malignancies 10 - 12 . (researchsquare.com)
  • Novel polyomavirus associated with brain tumors in free-ranging raccoons, western United States. (ictv.global)
  • The rate of pediatric brain tumors is increasing and cytotoxic therapy (i.e. chemotherapy and radiation) is seldom successful in significantly prolonging life or curing the patient. (sv40.org)
  • PHCT should be one of the differential diagnoses in patients with small hepatic tumor, even in regions with high prevalence of HBV infection and HCC. (biomedcentral.com)
  • Circulating tumor cells as promising novel biomarkers in solid cancers. (shengsci.com)
  • The presence of circulating tumor cells (CTCs) in peripheral blood can serve as a "liquid biopsy" approach and has thus emerged lately as one of the hottest fields in cancer research. (shengsci.com)
  • Reolysin, a strain of reovirus, has been studied extensively as an anticancer agent in the treatment of head and neck cancers, metastatic melanoma, and other solid-organ tumors. (medscape.com)
  • The Food and Drug Administration in the United States has approved one oncolytic herpes simplex virus expressing granulocyte-macrophage colony-stimulating factor (Talimogene Laherparepvec) for the treatment of metastatic melanoma, and others could soon follow for this and other cancers. (bvsalud.org)
  • Cancers associés aux virus en Afrique. (who.int)
  • The distinction among these various tumors is important both clinically and epidemiologically. (medscape.com)
  • ADV and bacterial infections may be indistinguishable clinically, necessitating additional and specific diagnostic investigation. (webmedcentral.com)
  • Adult X-linked immunodeficiency (XID) mice, IGM-/- single knockout and IGM-/- CD8-/- double knockout mice do not clear polyomavirus infection. (ictv.global)
  • Polyoma tumor development in neonatally polyoma-virus-infected CD4-/- and CD8-/- single knockout and CD4-/-8-/- double knockout mice. (ictv.global)
  • Variations in polyoma virus genotype in relation to tumor induction in mice. (ictv.global)
  • Identified in boxer dogs in 1984, the parasite Neospora caninum is harmless to humans, yet has been shown to be effective against tumour cells in mice. (theconversation.com)
  • The action of antithymocyte serum on tumor growth and metatasis was investigated by using an experimental model of lymphatic metastasis after injection of murine uterine cervix carcinoma No.27 (U27) cells into the footpad of mice. (eurekamag.com)
  • Smith A.L., Carrano V.A., Brownstein D.G. Response of weanling random-bred mice to infections with pneumonia trojan of mice (PVM) Laboratory. (skinmicrobiomecongressca.com)
  • Two SK-MEL3 tumors were transplanted into each flank of BALB/c nude mice, and the larger tumor was treated intratumorally (IT) with virus or mock injection. (bvsalud.org)
  • Direct IT injection of TPV/Δ66R/mIL-2 led to significantly greater rates of tumor regression compared to reconstituted control (RC) mice in the primary and distant tumor sites, whereas TPV/Δ2L/Δ66R/FliC treatment led to significantly greater rates of tumor regression in distant tumor sites only. (bvsalud.org)
  • A single SK-MEL3 tumor was transplanted into one flank of BALB/c nude mice and was treated either into the tail vein, the nearest rear leg to the tumor, or both. (bvsalud.org)
  • The results demonstrated that TPV/Δ66R/mIL-2 treatment IV or IM had significantly greater rates of tumor regression than RC-treated mice but failed to exert this effect when both routes were used simultaneously. (bvsalud.org)
  • Thus, despite the fact that all products required for oncogenic transformation in vitro were derived from the highly oncogenic Ad12, the recombinant virus did not produce tumors in vivo. (uu.nl)
  • However, the tumor biopsy revealed a malignant neoplasm that originating from neuroendocrine cells. (biomedcentral.com)
  • Carcinoid tumors are neuroendocrine origin neoplasm and may produce serotonin or other functional peptide hormones. (biomedcentral.com)
  • The terms 'neoplasm' and 'tumour' are used interchangeably. (who.int)
  • One research group reported that lithium inhibits the reproduction of several viruses, including herpes simplex viruses (HSV 1, HSV 2), adenovirus (the "common cold" virus), cytomegalovirus, Epstein-Barr virus (associated with mononucleosis and many cases of chronic fatigue), and the measles virus. (digitalnaturopath.com)
  • Adenovirus Respiratory Infections In Children. (webmedcentral.com)
  • Kunze W, Beier D, Groeger K. Adenovirus Respiratory Infections In Children. (webmedcentral.com)
  • Respiratory adenovirus (ADV) infections activate acute phase proteins, so they are often interpreted as bacterial infections. (webmedcentral.com)
  • To prevent infected cell lysis, recombinant replication deficiency virus has been developed as a gene delivery tool to replace wild-type adenovirus (recombinant AdV in "application" part). (genemedi.com)
  • Infection process of adenovirus. (genemedi.com)
  • We have constructed a nondefective recombinant virus between the nononcogenic adenovirus 5 (Ad5) and the highly oncogenic Ad12. (uu.nl)
  • These data show that tumor induction by adenovirus virions is not determined only by the gene products of the transforming region. (uu.nl)
  • CMV): A member of the herpes virus family which may induce the immune-deficient state or cause active illness, such as pneumonia, in a patient already immune-deficient due to chronic illness, such as cancer or organ transplantation therapy. (digitalnaturopath.com)
  • For recent decades, it has been recognized that malignant tumor cells potentially induce local and systemic immunosuppression 9 . (researchsquare.com)
  • This study retrospectively analyzed serum lymphocyte subsets and survival outcomes in intracranial germ cell tumors (iGCTs) patients. (researchsquare.com)
  • When compared with ADV-negative and influenza-positive patients, those with ADV infections showed significantly elevated serum CRP concentrations and left-shifted leukocyte counts. (webmedcentral.com)
  • A 48-year-old Chinese female with HBV infection for 15 years was regularly followed up at gastroenterology outpatient department by abdominal ultrasound (US) and serum alpha-fetoprotein (AFP) screening every six months. (biomedcentral.com)
  • Investigations of contacts and treatment of contacts with latent TB infection (LTBI) became a strategy in the control and elimination of TB ( 2, 3 ). (cdc.gov)
  • EBVaGC is defined by monoclonal proliferation of carcinoma cells with latent EBV infection, as demonstrated by EBV-encoded small RNA (EBER) in situ hybridization. (spandidos-publications.com)
  • 90% of the world's population by adulthood and establishes lifelong, latent infections. (spandidos-publications.com)
  • Some of these cases may be the result of reactivation of latent syphilis or cytomegalovirus (CMV) infection. (hearingreview.com)
  • All HIV-infected persons at risk for infection with M. tuberculosis must be carefully evaluated and, if indicated, administered therapy to prevent the progression of latent infection to active TB disease and avoid the complications associated with HIV-related TB. (cdc.gov)
  • Accordingly, it might be a nonspecific and insensitive tumor marker. (shengsci.com)
  • It is due to a heterozygous deletion on chromosome 19 that encodes a functional chimeric protein (DNAJB1-PRKACA) and characterized by being less aggressive with a normal alpha-fetoprotein (AFP) tumour marker and a female predominance [ 5 , 6 ]. (biomedcentral.com)
  • T-antigen knockdown studies show that MCV T antigen is needed for the tumor phenotype in MCV-positive tumor cells ( 11 ), and the extent of tumors in the patient is correlated with levels of antibodies to MCV T antigen ( 12 ), leaving little doubt that MCV is the infectious cause for most but not all MCC tumors. (cdc.gov)
  • 17 - 22 The cell surface phenotype of BL tumour cells reflects a GC origin but the site of tumour growth is frequently the jaw or ovary, neither of which normally contain GCs. (bmj.com)
  • Hepatitis B virus reactivation in patients undergoing cytotoxic chemotherapy for solid tumours: precore/core mutations may play an important role. (koreamed.org)
  • Studies in experimental incidence and multiplicity of tumours to Wilms tumour in humans - in the animals increase and the latency period de adult rat after perinatal exposure to a creases with increasing dose. (who.int)
  • Furthermore, injection of the virus into hamsters produces the same tumours. (sv40.org)
  • We undertook a more thorough investigation to rule out the possibility that the liver tumor was a metastatic carcinoid. (biomedcentral.com)
  • resection of these tumors resulted in long tumor-free survival in some patients (5,6). (cdc.gov)
  • There was no tumor embolus in the vessels and the resection line was free from tumor invasion. (biomedcentral.com)
  • A total of 171 patients between the ages of one month and 16 years were selected for study, of which 106 were ADV-positive, 32 were ADV-negative, and 33 were positive for influenza virus. (webmedcentral.com)
  • The study population ranged from one month to 16 years of age.Children with ADV infections had been routinely examined and treated in the interval of November 2003 to June 2007, while those with Influenza virus were seen between February and May 2005. (webmedcentral.com)
  • CTCs can be isolated from blood in a non-invasive approach, and can be used to follow patients over time since these cells can provide significant information for a better understanding of tumor biology and tumor cell dissemination. (shengsci.com)
  • For recurrent, invasive tumors, more aggressive attempts at excision or electroporation may be required. (merckvetmanual.com)
  • It is conceivable that this change may be related to that which enables the cells of a compact tumor to become invasive. (onclive.com)
  • Cases of invasive cervical cancer diagnosed in AN women aged 18 and above between 1980 and 2007 were identified from the Alaska Native Tumor Registry. (cdc.gov)
  • 76 patients were confirmed germinoma, 29 mixed germ cell tumor, 4 teratoma, 9 malignant teratoma, 6 endodermal sinus tumor, 20 choriocarcinoma and 1 embryonal carcinoma. (researchsquare.com)
  • Classification of central nervous system germ cell tumors according to the World Health Organization divides them into germinoma and non-germinoma germ cell tumors(NGGCTs), with 6 different types of the latter, which includes teratoma, embryonal carcinoma, endodermal sinus tumor (yolk sac tumor), chorionic epithelioma (also called choriocarcinoma) and mixed germ cell tumors(GCTs) 7 (including above components sometimes teratoma and germinoma as well). (researchsquare.com)
  • Lamivudine therapy for hepatitis B virus reactivation in a patient receiving intra-arterial chemotherapy for advanced hepato-cellular carcinoma. (koreamed.org)
  • Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is a distinct subtype that accounts for nearly 10% of gastric carcinomas. (spandidos-publications.com)
  • The uniformity of the numbers of terminal repeats (TRs) among EBV positive carcinoma cells reflects the clonal origin of a tumor and suggests that EBV is a causative virus for gastric carcinoma ( 6 ). (spandidos-publications.com)
  • Persistent infection with H. pylori induces atrophic gastritis and intestinal metaplasia, and subsequently leads to gastric malignancies including gastric carcinoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). (spandidos-publications.com)
  • Hepatocellular carcinoma (HCC) was considered based on the image findings and underlying HBV infection. (biomedcentral.com)
  • An initial correlation between chronic hepatitis B virus infection and MCV prevalence could not be confirmed among MCV seroconverters or in studies of a second hepatitis B virus-hyperendemic cohort from Qidong, China. (cdc.gov)
  • [ 5 ] Because of their widespread prevalence in nature and the ease of infection in laboratory animals, reoviruses have been used widely in pathogenicity studies. (medscape.com)
  • Parker J.C., Tennant R.W., Ward T.G. Prevalence of infections in mouse colonies. (skinmicrobiomecongressca.com)
  • Given the importance that this disease has for Equidae associated with the role that horses play in the development of livestock on the island, the aim of this study was to determine the prevalence of EIA on Marajó Island, at the mouth of the Amazon river, since there are no reports in the literature of this infection for this region. (scielo.br)
  • In 1872, Moritz Kaposi described a blood vessel tumor (originally called "idiopathic multiple pigmented sarcoma of the skin") that has since been eponymously named Kaposi's sarcoma (KS). (wikidoc.org)
  • Similarities between chronic idiopathic granulomatous ileocolitis and mycobacterial infections have been noted since the original descriptions of the clinical syndrome now called Crohn's disease. (bmj.com)
  • For viruses like mumps, measles, and rubella, there is evidence that they may be the cause of idiopathic sudden sensorineural hearing loss (ISSNHL). (hearingreview.com)
  • For other viruses, there clearly is an association with idiopathic sudden sensorineural hearing loss, although a convincing evidence of a causal relationship is lacking. (hearingreview.com)
  • The same thing is happening with other causes of infections in humans: fungi, viruses and parasites. (theconversation.com)
  • Only two species of the Cryptosporidium parasite cause infections in humans. (theconversation.com)
  • TPV replicates only in humans and monkeys, including tumor cells, which makes the use of syngeneic tumor models impossible for the study of this OV in a standard immunocompetent system. (bvsalud.org)
  • Genomic characterization of a novel virus found in papillomatous lesions from a southern brown bandicoot ( Isoodon obesulus ) in Western Australia. (ictv.global)
  • The idea behind this experiment was that if a virus causes KS, the genomic DNA in the two samples should be precisely identical except for DNA belonging to the virus. (wikidoc.org)
  • A serologic study of adult commercial blood donors that used human polyomavirus 6 and 7 virus-like particles showed that these viruses are also widely established in the human population with 69% and 35% seroprevalence, respectively ( 19 ). (cdc.gov)
  • 14 patients with chronic symptoms of disabling fatigue in association with serologic evidence of active Epstein-Barr virus ( EBV ) infection were studied. (digitalnaturopath.com)
  • Eighty-six percent had serologic evidence of cytomegalovirus ( CMV ) infection. (digitalnaturopath.com)
  • We used infliximab or etanercept therapy in patients with rheumatic disease and chronic HBV infection. (koreamed.org)
  • Acute hepatic injury after discontinuation of chemotherapy in a patient with non-Hodgkin's lymphoma and chronic hepatitis B virus infection. (koreamed.org)
  • Also see Candidiasis , Candidiasis Empiric Therapy , Mucosal Candidiasis , Chronic Mucocutaneous Candidiasis , and Noncandidal Fungal Infections of the Mouth . (medscape.com)
  • The Iowa reports led cancer researcher Richard E. Shope to investigate, and he discovered the virus in 1933. (wikipedia.org)
  • Shope's research led to the development of the first mammalian model of cancer caused by a virus. (wikipedia.org)
  • It is common to evaluate lymphocytes subsets in virus infection, immunodeficiency diseases and cancer. (researchsquare.com)
  • 11). ᄋksuzoglu B., Kilickap S., Yalcin S. Reactivation of hepatitis B virus infection in pancreatic cancer: a case report. (koreamed.org)
  • Epstein-Barr virus (EBV) infection, malaria, immunodeficiency and spontaneous, somatic mutation can all contribute to the origin and maintenance of this cancer and their mechanisms are the subject of this review. (bmj.com)
  • This virus causes Kaposi's sarcoma , a cancer commonly occurring in AIDS patients, as well as primary effusion lymphoma and some types of multicentric Castleman's disease . (wikidoc.org)
  • With the onset of the AIDS epidemic in the early 1980s, there was a sudden epidemic resurgence of KS affecting primarily gay and bisexual AIDS patients with up to 50% of reported AIDS patients having this tumor--an extraordinary rate of cancer predisposition. (wikidoc.org)
  • Evidence points to a role for c-Met and RON signaling in tumor progression by increasing proliferation, inhibiting apoptosis, contributing to angiogenesis, promoting metastasis and in maintenance of cancer stem cells [ 11 - 14 ]. (oncotarget.com)
  • When Henrietta Lacks, a 31-year-old African American woman with advanced cervical cancer began to receive treatment for her disease at John Hopkins Hospital in 1951-1 of the only hospitals at the time that was willing to provide treatment to African American patients-a tissue biopsy was taken from her tumor. (onclive.com)
  • Cytomegalovirus ( CMV ) is a virus belonging to the herpes family. (digitalnaturopath.com)
  • Precipitating factors include herpes simplex virus (HSV), Epstein-Barr virus (EBV), and histoplasmosis. (medscape.com)
  • A major cause of erythema multiforme is the herpes virus (HSV). (medscape.com)
  • Epstein-Barr virus (EBV), also known as human herpes virus 4, is a gamma-herpes virus that consists of double-stranded DNA of ~170 kb in length. (spandidos-publications.com)
  • The breakthrough came in 1994, when the Kaposi sarcoma-associated herpes virus (human herpesvirus type 8 [HHV-8]) was identified using representational difference analysis. (medscape.com)
  • The most common etiologic association with erythema multiforme is herpes simplex virus (HSV) infection, which is frequently concomitant with the EM flare. (jcadonline.com)
  • Li B, Shi Y, Shu J, Gao J, Wu P and Tang S-J, 2013 Wingless-type mammary tumor virus integration site family, member 5A (Wnt5a) regulates human immunodeficiency virus type1 (HIV-1) envelope glycoprotein 120 (gp 120)-induced expression of pro-inflammatory cytokines via the Ca2+/calmodulin-dependent protein kinase II (caMKII) and c-JUN N-terminal kinase (JNK) signaling pathways. (utmb.edu)
  • It can also result in the reactivation of syphilis in patients with HIV (human immunodeficiency virus) infection. (hearingreview.com)
  • These guidelines update previous CDC recommendations for the diagnosis, treatment, and prevention of tuberculosis (TB) among adults and children coinfected with human immunodeficiency virus (HIV) in the United States. (cdc.gov)
  • These guidelines update previous CDC recommendations for treating and preventing active tuberculosis (TB) among adults and children coinfected with human immunodeficiency virus (HIV) (1-3). (cdc.gov)
  • High-risk groups for HCC in which screening could be considered include HBV carriers (6,8), patients with cirrhosis of any etiology or hemochromatosis (9,10), and possibly patients with hepatitis C virus infection and other non-A, non-B hepatitis infections (11,12). (cdc.gov)
  • He was able to isolate virus particles from tumors on captured animals and use these to inoculate domestic rabbits, which then developed similar tumors. (wikipedia.org)
  • Primary hepatic carcinoid tumor (PHCT) is very rare and difficult to diagnose before biopsy or operation. (biomedcentral.com)
  • Based on the imaging findings and underlying HBV infection, small HCC was highly suspected and a US-guided liver biopsy was performed for definite diagnosis. (biomedcentral.com)
  • Acute nonlymphocytic leukaemia in adults : treatment and infection prevention / A. W. Dekker. (who.int)
  • Epidemiology of leukaemia and lymphoma : report of the Leukaemia Research Fund International Workshop, Oxford, UK, September 1984 / editors, M. F. Greaves and L. C. Chan. (who.int)
  • The Shope papilloma virus (SPV), also known as cottontail rabbit papilloma virus (CRPV) or Kappapapillomavirus 2, is a papillomavirus which infects certain leporids, causing keratinous carcinomas resembling horns, typically on or near the animal's head. (wikipedia.org)
  • Shope determined the protrusions were keratinous carcinomas due to the infection of CRPV. (wikipedia.org)
  • Merkel cell polyomavirus (MCV) is a recently discovered virus that causes 80% of Merkel cell carcinomas. (cdc.gov)
  • Infection with HPV causes virtually all cervical squamous cell carcinomas and cervical adenocarcinomas ( 3 - 5 ). (cdc.gov)
  • No signs, symptoms, or routine diagnostic test results were associated with MCV infection, and no correlation between HIV infection or AIDS progression and MCV infection was noted. (cdc.gov)
  • c-Met and RON show increased expression or activity in a variety of tumors leading to tumor progression and may play a role in acquired resistance to therapy. (oncotarget.com)
  • This phenomenon offers some explanation for the increased incidence of Burkitt's tumour and the high levels of immunoglobulin found in people living in areas where P. falciparum malaria is common. (ox.ac.uk)
  • The rising incidence in the West is due to increasing incidence of hepatitis C infection [ 1 ]. (biomedcentral.com)
  • Despite numerous reports describing seroprevalence for human polyomaviruses, less is known about seroconversion or signs and symptoms of primary polyomavirus infection ( 13 , 14 , 20 ). (cdc.gov)
  • Human respiratory syncytial virus (RSV) is a ubiquitous virus of worldwide distribution and is the leading cause of infant morbidity from respiratory infections. (intechopen.com)
  • Acute respiratory infections are frequently attributable to respiratory syncytial (RSV) or influenza viruses or rhino-, entero- and adenoviruses. (webmedcentral.com)
  • BK virus (BKV) and John Cunningham virus (JCV), for example, are ubiquitous human polyomavirus infections. (cdc.gov)
  • 1 BL tumour cells usually express IgM, 13 - 15 B-cell markers such as CD19, CD20 and CD22 and markers of germinal centre (GC) centroblasts such as CD10, BCL6 4 and the human germinal centre-associated lymphoma (HGAL) protein. (bmj.com)
  • An identical miRNA of the human JC and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune elimination. (ictv.global)
  • Quantification of human and animal viruses to differentiate the origin of the fecal contamination present in environmental samples. (ictv.global)
  • The development of animal models of dengue virus (DENV) infection and disease has been challenging, as epidemic DENV does not naturally infect non-human species. (mdpi.com)
  • EBV was the first virus to be associated with human malignancy, which was discovered from a Burkitt's lymphoma cell line in 1964 ( 1 ). (spandidos-publications.com)
  • ADV infection was confirmed via quantitative polymerase chain reaction (PCR) testing of nasopharyngeal swabs for human ADV-DNA. (webmedcentral.com)
  • The recombinant virus replicated efficiently in human embryonic kidney cells and HeLa cells, showing that the transforming regions of Ad5 and Ad12 had similar functions in productive infection. (uu.nl)
  • The Monographs programme has since been expanded to include consideration of exposures to complex mixtures of chemicals (which occur, for example, in some occupations and as a result of human habits) and of exposures to other agents, such as radiation and viruses. (who.int)
  • After the recombinant virus was injected into newborn hamsters, no tumors were produced during an observation period of 200 days. (uu.nl)
  • Treatment for these tumors targets local control using localized techniques described above. (merckvetmanual.com)
  • A vaccine targets a virus in a particular form. (healthline.com)
  • Characterization of wild type strains with widely differing tumor profiles. (ictv.global)
  • Hands on experience in techniques involving recombinant DNA technology such as preparation of plasmid DNA, transformation of bacteria by plasmid DNA, characterization of plasmids, cloning of DNA fragments into vectors, vaccinia virus, hybridization and electrophoretic procedures. (sprayprotectgo.com)
  • Viruses have long been held to be of pathogenetic importance in the evolution of autoimmune connective tissue disease. (digitalnaturopath.com)
  • Chang and Moore used representational difference analysis , or RDA, to find KSHV by comparing KS tumor tissue from an AIDS patient to his own unaffected tissue. (wikidoc.org)
  • The resected liver tissue contained a 1.6 × 1.6 × 1.5 cm circumscribed tumor (Fig. 3 ). (biomedcentral.com)
  • The virions of Reoviridae family viruses measure 60-80 nm in diameter and possess 2 concentric capsid shells, each of which is icosahedral. (medscape.com)
  • recently discovered Merkel cell polyomavirus (MCV) clonally integrated in the tumor cell genome of ≈80% of MCC ( 4 ). (cdc.gov)
  • reticulum cell sarcomas, cutaneous nodular amyloidosis) are relatively common cutaneous tumors. (merckvetmanual.com)
  • However, the tumour cells have undergone hypermutation, 21 23 a feature of the GC reaction during B-cell activation and differentiation. (bmj.com)
  • T-cell control of Epstein-Barr virus-infected B cells is lost during P. falciparum malaria. (ox.ac.uk)
  • KSHV is a herpesvirus , and is a large double-stranded DNA virus with a protein covering that packages its nucleic acids, called the virion , which is then surrounded by an amorphous protein layer called the tegument , and finally enclosed in a lipid envelope derived in part from the cell membrane. (wikidoc.org)
  • A careful analysis of c-Met/RON expression or activity and a better elucidation of how they influence cell signaling will be useful in predicting which tumors respond best to these inhibitors as well as determining which agents can be used with these inhibitors for combined therapy. (oncotarget.com)
  • Although the research that emerged from the discovery of the HeLa cell line has helped to prevent 4.5 billion global infections and 10.3 million global deaths, the unethical and controversial nature of their discovery has raised issues with regard to privacy and consent in underrepresented patient populations. (onclive.com)
  • Based on these findings, investigators concluded that these methods would be useful for examining mammalian cell growth, physiology, genetics, and biochemistry in addition to examining how cells respond to drugs, viruses, and high-energy radiation. (onclive.com)
  • Global CpG island hypermethylation, which induces epigenetic silencing of tumor suppressor genes, is also a unique feature of EBVaGC and is considered to be crucial for its carcinogenesis. (spandidos-publications.com)
  • Live vector vaccines use non-HIV viruses to carry HIV genes into the body to trigger an immune response. (healthline.com)
  • Burkitt lymphoma (BL) can be classified into three forms which differ in geographic distribution and Epstein-Barr virus (EBV) association: endemic (eBL), sporadic (sBL) and HIV-associated BL ( table 1 ). (bmj.com)
  • Endemic Burkitt's lymphoma, a tumour of children in which B lymphocytes are infected with Epstein-Barr virus (EBV), is common in areas of Africa where malaria is holoendemic. (ox.ac.uk)
  • MCV in MCC tumors possesses specific mutations that disable virus replication ( 9 ), which indicates that MCV is not a passenger virus and provides an explanation for how a common infection can lead to a rare tumor. (cdc.gov)
  • KS was thought to be an uncommon tumor of Jewish and Mediterranean populations until it was realized that it is actually quite common throughout sub-Saharan Africa. (wikidoc.org)
  • 17 These results are consistent with two possibilities: either MAP infection could cause Crohn's disease in a subset of patients that are either selectively exposed to this organism or who are genetically susceptible to infection or, alternatively, this relatively common dietary organism may selectively colonise (or a dead organism selectively lodge in) the ulcerated mucosa of Crohn's disease patients but not initiate or perpetuate intestinal inflammation. (bmj.com)
  • Approximately 74% of all carcinoid tumors arise from the gastrointestinal (GI) tract and the liver is a common site for metastases [ 1 ]. (biomedcentral.com)
  • Microsporidian infections are common in many fish species, yet detailed studies of these parasites in ecologically important wild populations are rare. (bvsalud.org)
  • 5] Keratinocyte apoptosis is then induced by tumor necrosis factor (TNF-a) released from keratinocytes, macrophages, and monocytes. (jcadonline.com)
  • There is no doubt that a potential source of zoonotic infection exists, with widespread MAP infections in the dairy herds of Europe, North America, and Australia, 13, 14 excretion of MAP in milk from infected cows, 15 relative resistance of intracellular MAP to widely used pasteurisation techniques, 16 and recovery of viable MAP from the water supplying Los Angeles. (bmj.com)
  • However, immunodeficient patients and those receiving immunosuppressives may develop pneumonia or other secondary infections. (digitalnaturopath.com)
  • With most infections, vaccines buy the body more time to clear the infection on its own before disease occurs. (healthline.com)
  • The double-shelled particle is the complete infectious form of the virus. (medscape.com)
  • Equine infectious anemia (EIA) is a transmissible and incurable disease caused by a lentivirus, the equine infectious anemia virus (EIAV). (scielo.br)
  • Equine Infectious Anemia Virus (EIAV): what has HIV's country cousin got to tell us? (scielo.br)
  • Adding to CDC's current recommendations for administering isoniazid preventive therapy to HIV-infected persons with positive tuberculin skin tests and to HIV-infected persons who were exposed to patients with infectious TB, this report also describes in detail the use of new short-course (i.e., 2 months) multidrug regimens (e.g., a rifamycin, such as rifampin or rifabutin, combined with pyrazinamide) to prevent TB in persons with HIV infection. (cdc.gov)
  • However, it is ambiguous for simple tumor makers to evaluate patients' changing conditions and to predict outcomes, not to mention the evaluation and prognostic significance of patients with negative tumor indicators. (researchsquare.com)
  • When tumors are multiple or when surgical excision is not feasible, radiation therapy appears to be the best secondary treatment. (merckvetmanual.com)
  • Low-grade tumors may recur and infiltrate adjacent structures. (medscape.com)
  • As early as 1984, scientists had reported seeing herpesvirus-like structures in KS tumors by electron microscopy . (wikidoc.org)