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  • 1999
  • The structure of the ectodomain has striking similarities to the membranebound carboxy peptidase II (Lawrence et al 1999), suggesting that they have evolved from a common peptidase (Bzdega et al 1997). (ifcc.org)
  • antibody
  • 32. The method of claim 1 or 2 wherein said antibody preferentially inhibits fibrinogen binding to α v β 3 compared to fibrinogen binding to α IIb β 3 . (google.com.au)
  • The fibrinogen-derived peptide Bβ15-42 bound to HSVECs ( K d 0.18 μmol/L). Preincubation of HSVECs with Bβ15-42, a neutralizing antibody to urokinase plasminogen activator (uPA), or the F(ab) 1 fragment of a monoclonal antibody to vascular endothelial cadherin significantly attenuated the increase in ICAM-1 stimulated by fibrinogen. (ahajournals.org)
  • In keeping with this hypothesis, fibrinogen has been shown to mediate endothelium-dependent vasoactive effects on the saphenous vein that can be partially inhibited by a neutralizing antibody against ICAM-1. (ahajournals.org)
  • vascular
  • The demonstration that fibrinogen acts as a bridging ligand for adhesion of THP-1 cells (a monocytic cell line) to cultured HUVECs 12 could signify a potential mechanism for the promotion of monocyte infiltration into the vascular wall. (ahajournals.org)

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  • addition
  • In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. (wikipedia.org)
  • studies
  • Together with data from in vitro studies demonstrating clots formed from purified γA/γ′ fibrinogen are composed of abnormally structured fibers and are highly resistant to fibrinolysis, 12 - 15 these observations have led to the notion that γA/γ′ fibrinogen is a causal risk factor for CVD. (ahajournals.org)
  • In contrast to previous studies, Appiah et al 16 conclude that γ′ fibrinogen levels reflect an inflammatory process that accompanies, and may promote, CVD, but that γ′ fibrinogen does not independently contribute to CVD. (ahajournals.org)