• 1999
  • The structure of the ectodomain has striking similarities to the membranebound carboxy peptidase II (Lawrence et al 1999), suggesting that they have evolved from a common peptidase (Bzdega et al 1997). (ifcc.org)
  • antibody
  • 32. The method of claim 1 or 2 wherein said antibody preferentially inhibits fibrinogen binding to α v β 3 compared to fibrinogen binding to α IIb β 3 . (google.com.au)
  • The fibrinogen-derived peptide Bβ15-42 bound to HSVECs ( K d 0.18 μmol/L). Preincubation of HSVECs with Bβ15-42, a neutralizing antibody to urokinase plasminogen activator (uPA), or the F(ab) 1 fragment of a monoclonal antibody to vascular endothelial cadherin significantly attenuated the increase in ICAM-1 stimulated by fibrinogen. (ahajournals.org)
  • In keeping with this hypothesis, fibrinogen has been shown to mediate endothelium-dependent vasoactive effects on the saphenous vein that can be partially inhibited by a neutralizing antibody against ICAM-1. (ahajournals.org)
  • vascular
  • The demonstration that fibrinogen acts as a bridging ligand for adhesion of THP-1 cells (a monocytic cell line) to cultured HUVECs 12 could signify a potential mechanism for the promotion of monocyte infiltration into the vascular wall. (ahajournals.org)
  • release
  • Capillary electrophoretic analysis indicated that anti-uPA prevented the release of any fibrinopeptide B (Bβ1-14) in cultures of HSVECs incubated with 4 μmol/L fibrinogen for 6 hours. (ahajournals.org)