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  • Eicosanoids
  • Eicosanoids derived from the arachidonic acid cascade have been implicated in the pathogenesis of a variety of human diseases, including cancer, and are now believed to play important roles in tumor promotion, progression, and metastatic disease. (aacrjournals.org)
  • Mediators
  • In addition, γ-linolenic acid suppresses inflammation mediators such as interleukin 1β (IL-1β), interleukin 6 (IL-6), and cytokine - tumor necrosis factor α (TNF-α). (mdpi.com)
  • 1987
  • Cordis GA, Prasad MR, Otani H, Engelman RM, Das DK (1987) Measurement of polyunsaturated fatty acids and acyl chain composition of myocardial lipids by high performance liquid chromatography. (springer.com)
  • Unterberg A, Wahl M, Hammersen F, Baethmann A (1987) Permeability and vasomotor response of cerebral vessels during exposure to arachidonic acid. (springer.com)
  • cysteinyl
  • There has also been postulated the existence of LTG4, a metabolite of LTE4 in which the cysteinyl moiety has been oxidized to an alpha-keto-acid (i.e.-the cysteine has been replaced by a pyruvate). (wikipedia.org)
  • citation needed] In cells that express LTC4 synthase, such as mast cells and eosinophils, LTA4 is conjugated with the tripeptide glutathione to form the first of the cysteinyl-leukotrienes, LTC4. (wikipedia.org)
  • cascade
  • The use of this novel blocking agent with diffuse effects in the arachidonic cascade was not beneficial for the reduction or prevention of brain oedema. (springer.com)
  • humans
  • J. W. Weiss, J. M. Drazen and N. Cole, Bronchoconstrictor effects of leukotriene C in humans . (springer.com)
  • Black KL, Hoff JT, McGillicuddy JE, Gebarski SS (1986) Increased leukotriene C4 and vasogenicoedema surrounding brain tumours in humans. (springer.com)
  • phospholipids
  • Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine , phosphatidylcholine , and phosphatidylinositides ) of membranes of the body's cells , and is abundant in the brain , muscles , and liver . (wikipedia.org)
  • allergic
  • W. M. Abraham, A. Wanner, J. S. Stevenson and G. A. Chapman, The effect of an orally active leukotriene D 4 /E 4 antagonist LY-171883 on antigen-induced airway responses in allergic sheep . (springer.com)
  • 1981
  • M. C. Holroyde, R. E. C. Altouynyan, M. Cole, M. Dixon and E. V. Elliot, Bronchoconstriction produced in man by leukotrienes C and D . Lancet 2 , 17-18 (1981). (springer.com)
  • Ueno A, Tanaka K, Katori M, Hayashi MN, Arai Y (1981) Species difference in increased vascular permeability by synthetic leukotriene C4 and D4. (springer.com)
  • In 1981, researchers from the University of Texas Health Science Center discovered that by not feeding mice any 'essential' fatty acids, autoimmune disease was prevented and their lifespans were increased. (endalldisease.com)
  • human
  • Experiments have shown that unsaturated fatty acids inhibit the growth of the human fetus 15 and, in the absence of omega-3 and omega-6, both short-term and long-term memory of the fetus are improved. (endalldisease.com)
  • oxygen
  • The catalytic mechanism involves the insertion of an oxygen moiety at a specific position in the arachidonic acid backbone. (wikipedia.org)
  • Due to its high content of saturated fatty acids, coconut oil is stable and protected from reacting with oxygen (oxidation). (endalldisease.com)
  • As described in the introduction to this Perspective series ( 1 ), signaling by arachidonic acid represents a paradigm for the use of oxygen in the transmission of information. (jci.org)
  • active
  • One of the biologically active principles of SRS-A. It is generated from LEUKOTRIENE C4 after partial hydrolysis of the peptide chain, i.e., cleavage of the gamma-glutamyl portion. (curehunter.com)
  • substance
  • R. C. Murphy, S. Hammarstrom and B. Samuelsson, Leukotriene C, a slow-reacting substance from murine mastocytoma cells . (springer.com)
  • What would be later named leukotriene C, "slow reaction smooth muscle-stimulating substance" (SRS) was originally described between 1938 and 1940 by Feldberg and Kellaway. (wikipedia.org)
  • Cells
  • Leukotrienes use lipid signaling to convey information to either the cell producing them (autocrine signaling) or neighboring cells (paracrine signaling) in order to regulate immune responses. (wikipedia.org)
  • increase
  • Black KL, Hoff JT (1985) Leukotrienes increase blood-brain barrier permeability following intraparenchymal injection in rats. (springer.com)
  • EPO supplementation results in an increase in plasma levels of γ-linolenic acid and its metabolite dihomo-γ-linolenic acid (DGLA). (mdpi.com)
  • composition
  • The invention provides a composition comprising a reduced isoalpha acid (RIAA) and isoalpha acid (IAA) isolated from hops, wherein the RIAA and IAA are in a ratio of about 3:1 to about 1:10. (google.be)
  • 2 . The composition of claim 1 , wherein said isoalpha acid is selected from isohumulone, isocohumulone, and isoadhumulone. (google.be)
  • 3 . The composition of claim 1 , wherein said reduced isoalpha acid is selected from dihydro-isohumulone, dihydro-isocohumulone, and dihydro-adhumulone. (google.be)
  • eicosanoids
  • Eicosanoids derived from the arachidonic acid cascade have been implicated in the pathogenesis of a variety of human diseases, including cancer, and are now believed to play important roles in tumor promotion, progression, and metastatic disease. (aacrjournals.org)
  • mediators
  • In addition, γ-linolenic acid suppresses inflammation mediators such as interleukin 1β (IL-1β), interleukin 6 (IL-6), and cytokine - tumor necrosis factor α (TNF-α). (mdpi.com)
  • cells
  • Leukotrienes use lipid signaling to convey information to either the cell producing them (autocrine signaling) or neighboring cells (paracrine signaling) in order to regulate immune responses. (wikipedia.org)