• metabolite
  • The cysteinyl leukotrienes make up the slow-reacting substance of anaphylaxis (SRS-A). LTF4, like LTD4, is a metabolite of LTC4, but, unlike LTD4, which lacks the glutamic residue of glutathione, LTF4 lacks the glycine residue of glutathione. (wikipedia.org)
  • There has also been postulated the existence of LTG4, a metabolite of LTE4 in which the cysteinyl moiety has been oxidized to an alpha-keto-acid (i.e.-the cysteine has been replaced by a pyruvate). (wikipedia.org)
  • 1987
  • Cordis GA, Prasad MR, Otani H, Engelman RM, Das DK (1987) Measurement of polyunsaturated fatty acids and acyl chain composition of myocardial lipids by high performance liquid chromatography. (springer.com)
  • Unterberg A, Wahl M, Hammersen F, Baethmann A (1987) Permeability and vasomotor response of cerebral vessels during exposure to arachidonic acid. (springer.com)
  • receptors
  • citation needed] The cysteinyl-leukotrienes act at their cell-surface receptors CysLT1 and CysLT2 on target cells to contract bronchial and vascular smooth muscle, to increase permeability of small blood vessels, to enhance secretion of mucus in the airway and gut, and to recruit leukocytes to sites of inflammation. (wikipedia.org)
  • phospholipids
  • Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine , phosphatidylcholine , and phosphatidylinositides ) of membranes of the body's cells , and is abundant in the brain , muscles , and liver . (wikipedia.org)
  • allergic
  • W. M. Abraham, A. Wanner, J. S. Stevenson and G. A. Chapman, The effect of an orally active leukotriene D 4 /E 4 antagonist LY-171883 on antigen-induced airway responses in allergic sheep . (springer.com)
  • 1981
  • M. C. Holroyde, R. E. C. Altouynyan, M. Cole, M. Dixon and E. V. Elliot, Bronchoconstriction produced in man by leukotrienes C and D . Lancet 2 , 17-18 (1981). (springer.com)
  • Ueno A, Tanaka K, Katori M, Hayashi MN, Arai Y (1981) Species difference in increased vascular permeability by synthetic leukotriene C4 and D4. (springer.com)
  • In 1981, researchers from the University of Texas Health Science Center discovered that by not feeding mice any 'essential' fatty acids, autoimmune disease was prevented and their lifespans were increased. (endalldisease.com)
  • human
  • S. E. Dahlen, G. Hansson, P. Hedqvist, S. Hammarstrom and B. Samuelsson, Leukotrienes are potent constrictors of human bronchi . (springer.com)
  • Experiments have shown that unsaturated fatty acids inhibit the growth of the human fetus 15 and, in the absence of omega-3 and omega-6, both short-term and long-term memory of the fetus are improved. (endalldisease.com)
  • citation needed
  • citation needed] Leukotrienes are commercially available to the research community. (wikipedia.org)
  • citation needed] LTC4, LTD4, LTE4 and LTF4 are often called cysteinyl leukotrienes due to the presence of the amino acid cysteine in their structure. (wikipedia.org)
  • citation needed] In cells that express LTC4 synthase, such as mast cells and eosinophils, LTA4 is conjugated with the tripeptide glutathione to form the first of the cysteinyl-leukotrienes, LTC4. (wikipedia.org)
  • substance
  • R. C. Murphy, S. Hammarstrom and B. Samuelsson, Leukotriene C, a slow-reacting substance from murine mastocytoma cells . (springer.com)
  • What would be later named leukotriene C, "slow reaction smooth muscle-stimulating substance" (SRS) was originally described between 1938 and 1940 by Feldberg and Kellaway. (wikipedia.org)
  • Cells
  • Leukotrienes use lipid signaling to convey information to either the cell producing them (autocrine signaling) or neighboring cells (paracrine signaling) in order to regulate immune responses. (wikipedia.org)
  • composition
  • The invention provides a composition comprising a reduced isoalpha acid (RIAA) and isoalpha acid (IAA) isolated from hops, wherein the RIAA and IAA are in a ratio of about 3:1 to about 1:10. (google.be)
  • 2 . The composition of claim 1 , wherein said isoalpha acid is selected from isohumulone, isocohumulone, and isoadhumulone. (google.be)
  • 3 . The composition of claim 1 , wherein said reduced isoalpha acid is selected from dihydro-isohumulone, dihydro-isocohumulone, and dihydro-adhumulone. (google.be)
  • although
  • These results suggest that although ibuprofen can inhibit polymorphonuclear leukocyte and platelet influx into the ischemic and reperfused heart, it causes further damage to the already ischemic heart by reducing prostacyclin concentration and increasing free fatty acids in the heart. (springer.com)
  • However
  • However, almost all writings in biology, medicine and nutrition limit the term to all - cis -5,8,11,14-eicosatetraenoic acid. (wikipedia.org)
  • A commercial source of arachidonic acid has been derived, however, from the fungus Mortierella alpina . (wikipedia.org)