• Mediators
  • Both of these metabolites, depending on the cell type which forms them, can be further metabolized to 15-oxo-eicosatetraenoic acid (15-oxo-ETE), 5S,15S-dihydroxy-eicosatetraenoic acid (5(S),15(S)-diHETE), 5-oxo-15(S)-hydroxyeicosatetraenoic acid (5-oxo-15(S)-HETE, a subset of specialized pro-resolving mediators viz. (wikipedia.org)
  • E. J. Goetzl, Mediators of immediate hypersensitivity derived from arachidonic acid . (springer.com)
  • fatty
  • These results suggest that although ibuprofen can inhibit polymorphonuclear leukocyte and platelet influx into the ischemic and reperfused heart, it causes further damage to the already ischemic heart by reducing prostacyclin concentration and increasing free fatty acids in the heart. (springer.com)
  • Cordis GA, Prasad MR, Otani H, Engelman RM, Das DK (1987) Measurement of polyunsaturated fatty acids and acyl chain composition of myocardial lipids by high performance liquid chromatography. (springer.com)
  • Many of the SPM are metabolites of omega-3 fatty acids and have been proposed to be responsible for the anti-inflammatory actions that are attributed to omega-3 fatty acid-rich diets. (wikipedia.org)
  • LTB4
  • 5-HETE can be further metabolized to 5-oxo-ETE and 5-oxo-15-hydroxy-ETE, all of which have pro-inflammatory actions similar but not identical to those of LTB4 and mediated not by LTB4 receptors but rather by the OXE receptor (see 5-Hydroxyicosatetraenoic acid and 5-oxo-eicosatetraenoic acid). (wikipedia.org)
  • In cells equipped with LTA hydrolase, such as neutrophils and monocytes, LTA4 is converted to the dihydroxy acid leukotriene LTB4, which is a powerful chemoattractant for neutrophils acting at BLT1 and BLT2 receptors on the plasma membrane of these cells. (wikipedia.org)
  • citation needed] Both LTB4 and the cysteinyl-leukotrienes (LTC4, LTD4, LTE4) are partly degraded in local tissues, and ultimately become inactive metabolites in the liver. (wikipedia.org)
  • receptors
  • citation needed] The cysteinyl-leukotrienes act at their cell-surface receptors CysLT1 and CysLT2 on target cells to contract bronchial and vascular smooth muscle, to increase permeability of small blood vessels, to enhance secretion of mucus in the airway and gut, and to recruit leukocytes to sites of inflammation. (wikipedia.org)
  • contractions
  • S. E. Dahlen, G. Hansson, P. Hedqvist T. Bjorck, E. Granstrom and B. Dahlen, Allergen challenge of lung tissue from asthmatics elicits bronchial contractions that correlate with the release of leukotrienes C 4 , D 4 , E 4 . (springer.com)
  • allergic
  • W. M. Abraham, A. Wanner, J. S. Stevenson and G. A. Chapman, The effect of an orally active leukotriene D 4 /E 4 antagonist LY-171883 on antigen-induced airway responses in allergic sheep . (springer.com)
  • 1981
  • M. C. Holroyde, R. E. C. Altouynyan, M. Cole, M. Dixon and E. V. Elliot, Bronchoconstriction produced in man by leukotrienes C and D . Lancet 2 , 17-18 (1981). (springer.com)
  • Ueno A, Tanaka K, Katori M, Hayashi MN, Arai Y (1981) Species difference in increased vascular permeability by synthetic leukotriene C4 and D4. (springer.com)
  • substance
  • R. C. Murphy, S. Hammarstrom and B. Samuelsson, Leukotriene C, a slow-reacting substance from murine mastocytoma cells . (springer.com)
  • What would be later named leukotriene C, "slow reaction smooth muscle-stimulating substance" (SRS) was originally described between 1938 and 1940 by Feldberg and Kellaway. (wikipedia.org)
  • Cells
  • Leukotrienes use lipid signaling to convey information to either the cell producing them (autocrine signaling) or neighboring cells (paracrine signaling) in order to regulate immune responses. (wikipedia.org)
  • citation needed] In cells that express LTC4 synthase, such as mast cells and eosinophils, LTA4 is conjugated with the tripeptide glutathione to form the first of the cysteinyl-leukotrienes, LTC4. (wikipedia.org)
  • Human
  • Leukotrienes (LT) C 4 , D 4 , and E 4 are major contributors to the pathobiology of human bronchial asthma. (springer.com)
  • S. E. Dahlen, G. Hansson, P. Hedqvist, S. Hammarstrom and B. Samuelsson, Leukotrienes are potent constrictors of human bronchi . (springer.com)
  • composition
  • The invention provides a composition comprising a reduced isoalpha acid (RIAA) and isoalpha acid (IAA) isolated from hops, wherein the RIAA and IAA are in a ratio of about 3:1 to about 1:10. (google.be)
  • 2 . The composition of claim 1 , wherein said isoalpha acid is selected from isohumulone, isocohumulone, and isoadhumulone. (google.be)
  • 3 . The composition of claim 1 , wherein said reduced isoalpha acid is selected from dihydro-isohumulone, dihydro-isocohumulone, and dihydro-adhumulone. (google.be)