• clinical
  • HSPs are clinically differentiated into 'pure' forms if spastic paraplegia with bladder involvement is the only clinical finding, and 'complicated' (or complex) forms if there are additional neurologic or systemic abnormalities. (uptodate.com)
  • family
  • Phenotypically, affected family members exhibited spastic quadriparesis, ataxia, and dystonia with onset in childhood and episodic neurological decline. (docme.ru)