It translocates to the nuclear membrane upon stimulation, where it co-localizes with 5-LOX activating protein (FLAP) and cytosolic phospholipase A 2 (cPLA 2 ) [ 5 ]. (biomedcentral.com)
Substrate1
There are atypical members of the phospholipase A2 family, such as PLA2G12B, that have no phospholipase activity with typical phospholipase substrate. (wikipedia.org)
The microtubule protein tubulin regulates adenylyl cyclase and phospholipase Cβ 1 (PLCβ 1 ) signaling via transactivation of the G-protein subunits Gαs, Gαi1, and Gαq. (jneurosci.org)
The interaction of tubulin with these polypeptides involves a GTP transfer from the exchangeable GTP-binding site (E site) of tubulin to Gα, which activates the G-protein (transactivation) ( Roychowdhury and Rasenick, 1994 ). (jneurosci.org)
ROS may induce intracellular calcium increase and subsequent contraction of PASMCs via direct or indirect interactions with protein kinases, phospholipases, sarcoplasmic calcium channels, transient receptor potential channels, voltage-dependent potassium channels and L-type calcium channels, whose relevance may vary under different experimental conditions. (ersjournals.com)
19962
This transporter selectively accumulates glutamate through a sodium-independent, ATP-dependent process (Naito and Ueda, 1983, Tabb and Ueda, 1991, Fykse and Fonnum, 1996), resulting in a high concentration of glutamate in each vesicle. (org.es)
1994). Though Muller cells take up glutamate, they do not label with glutamate antibodies (Jojich and Pourcho, 1996). (org.es)
Signaling1
These phospholipases are involved in cell signaling processes, such as inflammatory response. (wikipedia.org)
Phospholipids1
The enzyme phospholipase A2 (EC 3.1.1.4, PLA2, systematic name phosphatidylcholine 2-acylhydrolase) catalyse the cleavage of fatty acids in position 2 of phospholipids, hydrolyzing the bond between the second fatty acid "tail" and the glycerol molecule: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate This particular phospholipase specifically recognizes the sn2 acyl bond of phospholipids and catalytically hydrolyzes the bond, releasing arachidonic acid and lysophosphatidic acid. (wikipedia.org)
Bothropstoxin-I (BthTx-I) is a Lys49-phospholipase A 2 (Lys49-PLA 2 ) from the venom of Bothrops jararacussu, which despite of the lack of catalytic activity induces myotoxicity, inflammation and pain. (biomedcentral.com)
In this work, a general biochemical characterization in snake venom of serine proteases (SVSP), phospholipases A 2 (PLA 2 ), metalloproteases (SVMP) and hyaluronidases (SVH) of Crotalus aquilus (Ca), Crotalus polystictus (Cp) and Crotalus molossus nigrescens (Cmn) was done. (mdpi.com)
19901
Compounds classified as neurotransmitters have several characteristics in common (reviewed in Massey, 1990, Erulkar, 1994). (org.es)
Structural1
1983. Mass spectrometric methods in structural analysis of some vesicants. (cdc.gov)
Snake1
The extracellular forms of phospholipases A2 have been isolated from different venoms (snake, bee, and wasp), from virtually every studied mammalian tissue (including pancreas and kidney) as well as from bacteria. (wikipedia.org)
Additional1
CONCLUSIONS: HI declined considerably between 1966 to 1970 and 1988 to 1994, with no additional decline between 1988 to 1994 and 2005 to 2010. (cdc.gov)
Activation1
The effects of propofol on the endothelin-1-induced activation of phosphatidylinositol-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D were evaluated by measuring the formation of inositol phosphates and choline, respectively. (silverchair.com)
Antibodies to IBV may be detected by indirect immunofluorescent antibody test, ELISA and Haemagglutination inhibition (haemagglutinating IBV produced after enzymatic treatment by phospholipase C). (datexis.com)
Extracellular1
The extracellular forms of phospholipases A2 have been isolated from different venoms (snake, bee, and wasp), from virtually every studied mammalian tissue (including pancreas and kidney) as well as from bacteria. (wikipedia.org)
Francisco1
Presented in part at the annual meeting of the American Society of Anesthesiologists, San Francisco, California, October 15-19, 1994. (asahq.org)
Enzyme2
The enzyme phospholipase A2 (EC 3.1.1.4, PLA2, systematic name phosphatidylcholine 2-acylhydrolase) catalyse the cleavage of fatty acids in position 2 of phospholipids, hydrolyzing the bond between the second fatty acid "tail" and the glycerol molecule: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate This particular phospholipase specifically recognizes the sn2 acyl bond of phospholipids and catalytically hydrolyzes the bond, releasing arachidonic acid and lysophosphatidic acid. (wikipedia.org)
Enzyme products of Trichosporon include proteinases, lipases, and phospholipases, but the specific contribution of an individual enzyme to human disease remains unclear. (medscape.com)
Diacylglycerol2
Some eicosanoids are synthesized from diacylglycerol, released from the lipid bilayer by phospholipase C (see below). (wikipedia.org)
Agonist binding leads to stimulation of phospholipase C resulting in production of diacylglycerol, predicting whether you are there are binary trading scene, trader brokers with a. (forex-consultant.com)
Time2
He retired from NIEHS in 1994 to devote his time to lecturing. (nih.gov)
Phospholipase D2 (PLD2) shortens the time required for myeloid leukemic cell differentiation: mechanism of action. (univ-paris5.fr)
University1
In 1994 Rodbell, along with Alfred G. Gilman of the University of Texas Southwestern Medical Center, was awarded the Nobel Prize in Physiology or Medicine for their discovery of signal transduction. (nih.gov)
Development1
17. Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development. (nih.gov)