• sequences
  • Blomberg, B. and Tonegawa, S. DNA sequences of the joining regions of mouse λ light chain immunoglobulin genes. (springer.com)
  • Several problems have arisen along the way, among the most persistent being the uncertainty of whether two sequences are truly orthologous and the species divergence is being examined, or whether they are paralogous and the gene divergences are being examined. (springer.com)
  • The present invention is based on the discovery that Pellino gene, polynucleotide, and polypeptide sequences are amplified and/or overexpressed in cancer cells in mammals. (google.com)
  • chromosome 22
  • Consistent with the GenBank nomenclature, these human IGLL genes will be referred to as IGLL1 (14.1) , IGLL2 (16.2) , and IGLL3 (16.1) , reflecting their position on chromosome 22, as established by this report. (springer.com)
  • repertoire
  • Here, we report restriction in the diversity of VL gene usage with a dominance of clonally related B cells in the peripheral blood (PB) isotype-specific repertoire of AL patients. (springer.com)
  • receptors
  • In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. (genecards.org)
  • Mast cells can be stimulated to degranulate by allergens through cross-linking with immunoglobulin E receptors (e.g. (wikipedia.org)
  • 22q11.2
  • Hybridization with a λ-like gene-specific DNA probe to somatic cell hybrids revealed that these genes reside on 22q11.2 between the breakpoint cluster region ( BCR ) and the Ewing sarcoma breakpoint at 22q12 and that gene 16.1 was located distal to genes 14.1 and 16.2 . (springer.com)
  • diversity
  • More recently, TdT was detected in transient populations of peripheric cells in young rats and mice (12), The biological function of TdT remains unknown although its biochemical properties and its cellular distribution have suggested a possible role in the differentiation of lymphoid cells and in the generation of the diversity of immunoglobulins (4, 13). (springer.com)
  • 14.1
  • Three IGLL genes, 14.1, 16.1, and 16.2 are present in humans as opposed to one, λ5 ( Igll ), found in the mouse. (springer.com)
  • Gene 14.1 was found by PFGE to be proximal to 16.2 by at least 30 kilobases (kb). (springer.com)
  • We thus show the first physical linkage of the IGL and the IGLL genes, 14.1 and 16.2 . (springer.com)
  • Bauer, Jr., T. R. and Blomberg, B. A new λ-like light chain gene, 16.2, is related to genes 14.1 and 16.1 expressed in pre-B cells. (springer.com)
  • differentiation
  • The Presence of c-erbB-2 Gene Product-related Protein in Culture Medium Conditioned by Breast Cancer Cell Line SK-BR-3," Cell Growth & Differentiation 1:591-599, 1990. (patents.com)
  • evolutionary
  • We discuss the relevance of methylation patterns and CpG islands to expression, and the evolutionary significance of the IGLL gene duplications. (springer.com)
  • regulate
  • The compositions are effective to silence, down-regulate or suppress the expression of a validated target gene by stimulating the process of RNA interference of gene expression, thus inhibiting tumor growth. (google.fr)
  • protein
  • IGLC2 (Immunoglobulin Lambda Constant 2) is a Protein Coding gene. (genecards.org)
  • Ig mu chain C region is a protein that in humans is encoded by the IGHM gene. (wikipedia.org)
  • One type of mutation is gene amplification or overexpression, i.e., where a specific chromosomal region (including the cancer gene) has undergone a relative increase in DNA copy number, such that more copies of the cancer gene are present, or where the level of expression of a gene is increased, such that a correspondingly higher amount of mRNA and protein is produced, causing deleterious effects. (google.com)
  • expression
  • More particularly, the compositions and methods are directed toward a cancer or a precancerous growth in a mammal, associated with pathological expression of a certain target genes identified herein. (google.fr)
  • The compositions inhibit expression of the target gene when introduced into a tissue of the mammal. (google.fr)
  • The methods include administering the compositions of the invention to a subject in need thereof in an amount effective to inhibit expression of a target gene in a cancerous tissue or organ. (google.fr)
  • region
  • The Fc region of immunoglobulin E (IgE) becomes bound to mast cells and basophils and when IgE's paratopes bind to an antigen, it causes the cells to release histamine and other inflammatory mediators. (wikipedia.org)