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  • region genes
  • B lymphocyte differentiation occurs in fetal liver and adult bone marrow through a well-characterized pathway which includes the ordered assembly of immunoglobulin (Ig) heavy and light chain variable region genes followed by the expression of the assembled Ig chains (Alt et al. (springer.com)
  • Immunoglobulin V.sub.h region genes of the mouse are organized in overlapping clusters" Eur. (freepatentsonline.com)
  • Upon activation of the recombinase complex, first a diversity (D) region segment rearranges to one of four joining (J) segments (usually on both chromosomes), and then one of 50-100 variable (V) region genes rearranges to the D-J segment. (springer.com)
  • chromosome 22
  • Consistent with the GenBank nomenclature, these human IGLL genes will be referred to as IGLL1 (14.1) , IGLL2 (16.2) , and IGLL3 (16.1) , reflecting their position on chromosome 22, as established by this report. (springer.com)
  • fetal
  • The regulated expression of B-lineage associated genes during B-cell differentiation in bone marrow and fetal liver. (springer.com)
  • genomic
  • Genomic DNA was amplified by seminested polymerase chain reaction(PCR), and the cDNA corresponding to the RNA was amplified by PCR using primersspecific for each IgVH family. (biomedcentral.com)
  • amino
  • Polymorphisms were identified on overlapping BACs derived from the same individual such that 11 genes contain amino acid differences. (springer.com)
  • The most striking allelic differences are present in IGKV2 genes, which contain as many as 16 amino acid changes between alleles, the majority of which are in complementarity determining region (CDR) 1. (springer.com)
  • II: the amino acid sequence of the H-chain (mu-type), subgroup H III. (wikipedia.org)
  • Molecular
  • Immunoglobulin Idiotypes and Their Expression: ICN-UCLA Symposia on Molecular and Cellular Biology , Volume XX (C. A. Janeway, Jr., E. E. Sercarz, and H. Wigzell, eds. (springer.com)
  • sequence
  • If this first attempt fails to generate a productive (inframe) heavy chain protein coding sequence, a second V to DJ rearrangement can occur on the other chromosome. (springer.com)
  • As a result, "a functional variable region gene of a light chain contains two coding segments that are separated by a non-coding DNA sequence in unrearranged germ-line DNA" (Barbara et al. (wikipedia.org)
  • An antisense oligonucleotide complementary to a sequence in I.gamma.2b Increase .gamma.2b germline transcrips, stimulates B cell DNA synthesis, and inhibits immunoglobulin secretion, The Journal of Experimental Medicine 175:597-607 (1992). (freepatentsonline.com)
  • bone marrow
  • In some individuals, the disease comes to light only after the cancerous cells overwhelm the bone marrow resulting in anemia producing tiredness or weakness. (wikipedia.org)
  • receptors
  • In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. (genecards.org)
  • Mast cells can be stimulated to degranulate by allergens through cross-linking with immunoglobulin E receptors (e.g. (wikipedia.org)
  • variable
  • Fourteen variable genes (IGKV) were identified, of which nine are functional and two are open reading frame (ORF). (springer.com)
  • 1990
  • The Presence of c-erbB-2 Gene Product-related Protein in Culture Medium Conditioned by Breast Cancer Cell Line SK-BR-3," Cell Growth & Differentiation 1:591-599, 1990. (patents.com)
  • diversity
  • More recently, TdT was detected in transient populations of peripheric cells in young rats and mice (12), The biological function of TdT remains unknown although its biochemical properties and its cellular distribution have suggested a possible role in the differentiation of lymphoid cells and in the generation of the diversity of immunoglobulins (4, 13). (springer.com)
  • Clones
  • From the 55 analyzed clones seven expressed nonfunctionalrearrangements (pseudogenes) with stop codons, and 48 were found to expressfunctional genes. (biomedcentral.com)