• monoclonal antibodies
  • This discovery led her to develop methods to generate anti-HIV human monoclonal antibodies (mAbs) from the blood cells of HIV-infected individuals. (wikipedia.org)
  • Monoclonal antibodies, which are drugs of the same family as natalizumab, have also raised high levels of interest and research. (wikipedia.org)
  • Alemtuzumab, daclizumab and CD20 monoclonal antibodies such as rituximab, ocrelizumab and ofatumumab have all shown some benefit and are under study as potential treatments for MS. Nevertheless, their use has also been accompanied by the appearance of potentially dangerous adverse effects, most importantly opportunistic infections. (wikipedia.org)
  • While monoclonal antibodies are probably going to have some role in the treatment of the disease in the future, it is believed that it will be small due to the risks associated to them. (wikipedia.org)
  • enzyme-linke
  • Lunde MN, Ottesen EA (1980) Enzyme-linked immunosorbent assay (ELISA) for detecting IgM and IgE antibodies in human schistosomiasis. (springer.com)
  • The common tests used for detecting and quantifying ANAs are indirect immunofluorescence and enzyme-linked immunosorbent assay (ELISA). (wikipedia.org)
  • wherein
  • 2. A test apparatus according to claim 1, wherein a cap is provided to fit over the opening of said ball-release piece. (google.com)
  • 3. A test apparatus according to claim 1, wherein said receptacle tray has a series of wells arranged in rows parallel to each other. (google.com)
  • 4. A test apparatus according to claim 1, wherein said ball holder is a hollow tube with a closed second end. (google.com)
  • 5. A test apparatus according to claim 1, wherein said ball-release piece has a beveled open end with a series of nibs spaced along the inner circumferential edge of said beveled opening. (google.com)
  • 6. A test apparatus according to claim 5, wherein said ball-release piece has a flange portion arranged to fit snugly over one end of said ball holder. (google.com)
  • 7. A test apparatus according to claim 5 wherein said nibs of said ball-release piece are arranged to release one of said coated balls when said ball-release piece is pressed on its extended exterior surface at said opening. (google.com)
  • 8. A test apparatus according to claim 1 wherein said wells are hemispherical in shape. (google.com)
  • 9. A test apparatus according to claim 1 wherein said balls are polystyrene balls. (google.com)
  • 10. A test apparatus according to claim 1 wherein said wells are contoured to provide coverage of one of said coated balls with a minimum of a blood sample and to prevent the entrapment of air between said ball and the well. (google.com)
  • 2. An immobilized immunoadsorbent as set forth in claim 1 wherein said antibodies are bound to said polymer by imidocarbonate linkage. (google.es)
  • clinical
  • Immunologic and clinical parameters can be helpful in determining which HIV-infected persons are at particular risk for having PCP and, therefore, which are most likely to benefit from prophylaxis against PCP. (cdc.gov)
  • In recent years a number of clinical diagnostic tests have been developed which employ radioisotope labeled materials. (google.com)
  • She proposed quantifying the antibodies directed at the second and third variable loops (V2 and V3) of the HIV envelope protein gp120, as observed in the Phase 3 RV144 clinical HIV vaccine trial, which involved 16,402 participants in Thailand. (wikipedia.org)
  • A positive ANA test is seldom useful if other clinical or laboratory data supporting a diagnosis are not present. (wikipedia.org)
  • specific
  • Viral hepatitis, including so called serum hepatitis, which is a relatively common disease, has not been heretofore easily detected by a sensitive test which is both specific and reproducible for quickly determining whether or not the serum from a patient or a donor contains hepatitis associated antigens or antibodies. (google.com)
  • Zolla-Pazner's research indicated that the search for an effective vaccine should focus not only on inducing specific types of antibodies but on eliciting a durable antibody response, as post-hoc analysis showed the antibodies in diminishing amounts from year 1 to year 3. (wikipedia.org)
  • conjugating to said activated polymer substrate a mass of antibodies for binding thereto antigens which are specific to said antibodies. (google.es)
  • The invention also provides methods of detecting OI-M factors utilizing OI-M specific antibodies and immunodetection kits. (google.com)
  • These antibodies can be subdivided according to their specificity, and each subset has different propensities for specific disorders. (wikipedia.org)
  • infections
  • McLaren ML, Lillywhite JE, Dunne DW, Doenhoff MJ (1981 Serodiagnosis of human Schistosoma mansoni infections: enhanced sensitivity and specificity in ELISA using a fraction containing S. mansoni egg antigens w1 and a1. (springer.com)
  • She was also responsible for the description of immunologic abnormalities in the first patients with AIDS-related Mycobacterium avium-intracellulare infections and for identifying similar immunologic abnormalities in apparently healthy gay men who later developed AIDS. (wikipedia.org)
  • patients
  • Related to these investigations is the recent development of a test against JC virus antibodies which might help to predict what patients are at a greater risk of developing progressive multifocal leukoencephalopathy when taking natalizumab. (wikipedia.org)
  • human
  • I. A steric and kinetic model for formation of a complex from a human antibody, quinidine as a haptene and platelets and for fixation of complement by the complex. (springer.com)
  • In some individuals, antibodies to human antigens are produced. (wikipedia.org)
  • He continued to conduct research and publish books, including Man Unfolding (1972), The Survival of the Wisest (1973), World Population and Human Values: A New Reality (1981), and Anatomy of Reality: Merging of Intuition and Reason (1983). (wikipedia.org)
  • laboratory
  • Other activities carried out by the IPCS include the development of know-how for coping with chemical accidents, coordination of laboratory testing and epidemiological studies, and promotion of research on the mechanisms of the biological action of chemicals. (inchem.org)
  • Apparatus
  • Although there have been methods for determining the presence of antigenically active macromolecules such as intact viruses, virus capsids, subunits, bacteria, membranes, cell walls, hormones, etc., there has been a lack of a simple yet sensitive test method and apparatus for determining the presence of these materials. (google.com)
  • present
  • To determine the autoantibody or autoantibodies present in a patient, the Coombs test, also known as the antiglobulin test, is performed. (wikipedia.org)
  • The ANA test detects the autoantibodies present in an individual's blood serum. (wikipedia.org)
  • Reaction
  • This RIA technique must include some procedure for separating antibody-bound tracer from the unbound tracer after completion of the immune reaction, whereby the radioactivity of the separated components can be determined by scintillation counting. (google.com)
  • diagnosis
  • Tests for the diagnosis of immediate hypersensitivity to drugs and identification of drug allogenic determinants. (springer.com)
  • usually
  • The antibodies are usually directed against high-incidence antigens, therefore they also commonly act on allogenic RBCs (RBCs originating from outside the person themselves, e.g. in the case of a blood transfusion). (wikipedia.org)
  • AIDS
  • Later in 1981, the CDC would retroactively identify him as the first patient of the AIDS epidemic in the US. (wikipedia.org)
  • blood
  • AIHA) occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst (lyse), leading to an insufficient number of oxygen-carrying red blood cells in the circulation. (wikipedia.org)
  • individuals
  • Antibodies to V3 were subsequently identified as an additional correlate of protection exerting immune pressure on viruses infecting individuals who had received the vaccine. (wikipedia.org)
  • vaccine
  • The field trial set up to test the Salk vaccine was, according to O'Neill, "the most elaborate program of its kind in history, involving 20,000 physicians and public health officers, 64,000 school personnel, and 220,000 volunteers. (wikipedia.org)
  • Developing, testing, and manufacturing sufficient quantities of a vaccine is a process that takes many months. (wikipedia.org)
  • found
  • Tests in 1989 found that he was HIV-positive, and there has been speculation that he was infected by a prostitute who was infected by Arvid Noe, but as of 1997, this had not been proven. (wikipedia.org)
  • The presence of both antibodies is found in 30-60% of Sjögren's syndrome, anti-Ro antibodies alone are found in 50-70% of Sjögren's syndrome and 30% of SLE with cutaneous involvement, and anti-La antibodies are rarely found in isolation. (wikipedia.org)
  • drug
  • Binding of quinine- and quinidine-dependent drug antibodies to platelets is mediated by the Fab domain of the immunoglobulin G and is not Fc dependent. (springer.com)
  • Fab-mediated binding of drug- dependent antibodies to platelets in quinidine- and quinine-induced thrombocytopenia. (springer.com)
  • samples
  • Eighteen years later, molecular biologists at Tulane University in New Orleans test samples of his remains and find evidence of HIV. (wikipedia.org)