• glycoproteins
  • Dell A, McDowell RA, Rogers ME (1992): Glycan structures in glycoproteins and their analysis by fast atom bombardment mass spectrometry. (springer.com)
  • The glycoproteins are embedded in the lipid bilayer to form the viral spikes in the mature virion that are crucial for receptor recognition and virus entry while the SSP is responsible for modulating the response of GPC to acidic pH [ 6 , 7 , 8 ]. (mdpi.com)
  • Beginning in 1973, his laboratory has concentrated on the biogenesis, structure, and function of several important secreted and plasma membrane glycoproteins. (wikipedia.org)
  • He defined the biosynthesis and maturation of the vesicular stomatitis virus and other plasma membrane glycoproteins, identified the intracellular organelles that mediate recycling of the asialoglycoprotein and transferrin receptors, and clarified the role of pH changes in delivery of iron to cells and recycling of the transferrin receptor. (wikipedia.org)
  • Through this work on VSV she uncovered a mix of surface glycoproteins which resulted in a novel replication strategy for Negative Strand Viruses as well as Pseudotyping. (wikipedia.org)
  • The thogotovirus glycoprotein is not similar to the influenza virus glycoproteins (haemagglutinin and neuraminidase), and instead shows some similarities with the gp64 glycoprotein of baculoviruses, which infect insects. (wikipedia.org)
  • Virology
  • In: Comparative virology, K. Maramorosch and E. Kurstak, Eds. (springer.com)
  • Following his internship, he joined the U.S. Navy Medical Corps, where he was first exposed to virology research while assigned to the U.S. Navy Medical Research Institute in Bethesda, Maryland. (wikipedia.org)
  • Wagner joined the faculty at Yale University in 1951 and then moved to Johns Hopkins in 1957, where he became the director of the Infectious Disease Division and later the head of the Division of Virology. (wikipedia.org)
  • Following a brief stint as the virology section editor for the Journal of Bacteriology, run by the American Society for Microbiology, Wagner served as the founding editor-in-chief of the Journal of Virology, working with fellow editors Lloyd Kozloff and Norman Salzman. (wikipedia.org)
  • With Heinz Fraenkel-Conrat, Wagner collaborated in editing a vast 19-volume treatise called Comprehensive Virology. (wikipedia.org)
  • In the early 1980s, Wagner was among the group of American virologists who helped organize and became the founding members of the American Society for Virology. (wikipedia.org)
  • is an American biologist specialized in microbiology and virology. (wikipedia.org)
  • This enzyme converted RNA to DNA, and became a major breakthrough in virology. (wikipedia.org)
  • Herpes
  • The disease model was reconstructed based on scientific studies that indicate the primary pathogen in AIDS is Human Herpes Virus 6, variant A (HHV-6A) with Human Immunodeficiency Virus (HIV) acting as a co-factor to stimulate HHV-6A replication. (keephopealive.org)
  • In a phone call to Donald Carrigan, formerly associated with the Medical College of Wisconsin, I was told that Konstance Knox and Donald Carrigan have opened up a private lab to test for HHV-6 and other herpes viruses including Cytomegalovirus(CMV). (keephopealive.org)
  • Herpes Virus Diagnostics, Inc. (keephopealive.org)
  • infection
  • A recent outbreak of suspected viral infection in Kedougou Region (http://www.promedmail.org/direct.php?id=3626668) highlights the complexity of establishing a specific etiological agent in West Africa. (gideononline.com)
  • At least twenty arthropod-borne viruses are associated with known or suspected human infection in Senegal. (gideononline.com)
  • A single case of infection was reported in Senegal in 1965. (gideononline.com)
  • We will review the pathogenesis of Junín virus in various animal models and the role of innate and adaptive immunity during infection. (mdpi.com)
  • The role of hepatitis C virus (HCV) infection in the induction of type II mixed cryoglobulinemia (MCII) and the possible establishment of related lymphoproliferative disorders, such as B-cell non-Hodgkin lymphoma (B-NHL), is well ascertained. (mdpi.com)
  • Hepatitis C virus (HCV) infection is a major public health problem with an estimated three to four million people infected each year worldwide and about 170 million carriers [ 1 ]. (mdpi.com)
  • This immune complex-mediated vasculitis is characterized by a primary B-cell clonal proliferation accompanied by the deposition of immune complexes composed of complement factors, mono/oligoclonal IgMs with rheumatoid factor (RF) activity bound to oligo/polyclonal IgGs that, in the case of HCV infection, are mostly directed against HCV proteins [ 3 ]. (mdpi.com)
  • 8. A method of prophylactically controlling a viral infection in a mammal which comprises administering an amount effective to prophylactically control said viral infection of a compound of claim 1. (patentgenius.com)
  • The cells of mammals produce, in response to virus infection, a substance which enables cells to resist the multiplication of a variety of viruses. (patentgenius.com)
  • 1982
  • The journal launched in 1966, and Wagner continued in his role for 15 years, overseeing a large expansion in the size of the journal before stepping down in 1982 and being succeeded by Edward M. Scolnick. (wikipedia.org)
  • 1975
  • The first volume was reviewed in 1975 as somewhat difficult to understand for those unfamiliar to the field, but likely valuable as a reference work. (wikipedia.org)
  • He was promoted to Professor in 1976, and in 1983 was appointed Founding Member of the new Whitehead Institute for Biomedical Research by Founding Director David Baltimore (winner of the Nobel Prize in Physiology or Medicine, 1975). (wikipedia.org)
  • Dr. Baltimore later received the Nobel Prize in 1975 for his discovery. (wikipedia.org)
  • molecular biology
  • Much of his research focused on the molecular biology of the vesicular stomatitis virus. (wikipedia.org)
  • We will highlight current research regarding the role of molecular biology of Junín virus in elucidating virus attenuation. (mdpi.com)
  • Following two years of postdoctoral research at the M.R.C. Laboratory of Molecular Biology with Drs. Sydney Brenner and Francis Crick (winners of the Nobel Prize in Physiology or Medicine, 2002 and 1962, respectively), he joined the faculty of the MIT Department of Biology. (wikipedia.org)
  • He has served on the advisory boards of several other institutions, including the Biozentrum of the University of Basel, the European Molecular Biology Laboratory in Heidelberg, the Center for Molecular Biology Heidelberg (ZMBH) in Germany, the Life Sciences Institute of the University of Michigan, and the PEW Scholars Program in Biomedical Sciences. (wikipedia.org)
  • proteins
  • The requirement for capsid proteins in RNA replication suggests that these proteins are positive control elements for replication of paramyxovirus RNA. (springer.com)
  • Bensadoun A, Weinstein D (1976): Assay of proteins in the presence of interfering materials. (springer.com)
  • Attention is focused in this review on viral proteins that are known to mediate or influence virus-induced cell fusion. (springer.com)
  • Because these proteins also mediate or influence entry of virus into cells, the virion-cell fusion required for this entry is discussed as well. (springer.com)
  • The present invention concerns the product produced by inactivating extracellular or intracellular pathogenic virus in a biological composition without incurring substantial disruption or inactivation of cells and without significant loss of labile proteins or other valuable biological components also. (google.com)
  • His group has elucidated steps in folding and oligomerization of several proteins within the endoplasmic reticulum, showed that exit of newly made proteins from this organelle requires that they be properly folded, and developed probes for measurement of the redox state within the endoplasmic reticulum. (wikipedia.org)
  • To date, several host- and virus-related factors have been implicated in the progression to MCII, such as the virus-induced expansion of selected subsets of B-cell clones expressing discrete immunoglobulin variable (IgV) gene subfamilies, the involvement of complement factors and the specific role of some HCV proteins. (mdpi.com)
  • The present invention relates to recombinant proteins and peptides related to mycobacteria, and particularly to proteins of Mycobacterium tuberculosis that are coded for by adjacent open reading frames on complementary DNA strands of the genome and vectors for propagating and expressing those recombinants, as well as to peptides that correspond substantially in sequence to portions of those proteins. (google.com)
  • 2001
  • Colato A, Fontanari JF (2001) Soluble model for the accumulation of mutations in asexual populations. (springer.com)
  • Crotty S, Cameron CE, Andino R (2001) RNA virus error catastrophe: direct molecular test by using ribavirin. (springer.com)
  • Robert R. Wagner (1923-2001) was an American virologist who spent time on the faculty at Yale University, Johns Hopkins University, and finally the University of Virginia School of Medicine, from which he retired as professor emeritus in 1994. (wikipedia.org)
  • Wagner died of cancer in 2001. (wikipedia.org)
  • Huang
  • Alice Huang's father, Quentin K. Y. Huang, was orphaned at age 12 in Anhui, China and was taken in by a missionary. (wikipedia.org)
  • Alice Huang was born in Nanchang, the capital city of Jiangxi Province, in 1939. (wikipedia.org)
  • Huang emigrated to the U.S. in 1949. (wikipedia.org)
  • With continued researched and publications from other researchers, along with help from Dr. Huang, Dr. Baltimore discovered an enzyme, reverse transcriptase (in a mouse leukemia retrovirus), that converts RNA to DNA (involved in a process now known as reverse transcription). (wikipedia.org)
  • interferons
  • During the early 1960s, while at Johns Hopkins, he became involved in research on interferons, which eventually entered clinical use. (wikipedia.org)
  • Ronda E., Alonso M.L., Barasoain I. (1976) "In Vivo" Depression of Either Endotoxin or Virus-Induced Interferons by Rifampicin and Rifamycin Derivatives. (springer.com)
  • strains
  • For the research, she isolated a rabies type of virus which produced mutant strains interfering with viral growth. (wikipedia.org)
  • the genus also contains the species Dhori virus (DHOV) and its subtype Batken virus, as well as the species or strains Araguari virus, Aransas Bay virus (ABV), Bourbon virus, Jos virus (JOSV) and Upolu virus (UPOV), which have yet to be confirmed by the International Committee on Taxonomy of Viruses (ICTV). (wikipedia.org)
  • Reassortment of segments between strains has been observed in both ticks and mammals experimentally infected with more than one thogotovirus, but its significance in natural infections is unknown. (wikipedia.org)
  • postdoctoral
  • After his time in the Navy, Wagner moved to England to work as a postdoctoral fellow with Christopher Andrewes. (wikipedia.org)
  • protein
  • Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein. (atcc.org)
  • Butler, P. J. G., Klug, A.: Assembly of the particle of tobacco mosaic virus from RNA and disks of protein. (springer.com)
  • The techniques covered in previous chapters provide most of the basics for studying protein modifications. (springer.com)
  • Barnea G, Grumet M, Milev P, Silvennoinen O, Levy JB, Sap J, Schlessinger J (1994): Receptor tyrosine phosphatase b is expressed in th form of proteoglycan and binds to the extracellular matrix protein tenascin. (springer.com)
  • THOV and JOSV also encode the protein M-long (ML), which counters the host's innate immunity, in particular by suppressing the production of interferon. (wikipedia.org)
  • 1965
  • The minutes of the 1964 annual council meeting were approved as published in the March, 1965, issue of the American Journal of Tropical Medicine and Hygiene. (ajtmh.org)
  • 1993
  • Charlesworth D, Morgan MT, Charlesworth B (1993) Mutation accumulation in finite outbreeding and inbreeding populations. (springer.com)
  • Clarke D, Duarte E, Moya A, Elena S, Domingo E, Holland JJ (1993) Genetic bottlenecks and population passages cause profound fitness differences in RNA viruses. (springer.com)
  • Rift Valley virus was identified in mosquitoes in Barkedji in 1993, and re-emerged in 2002. (gideononline.com)
  • Carmo-Fonseca M, Ferreira J, Lamond A (1993): Assembly of snRNP-containing coii:.dbodies is regulated in interphase and mitosis-evidence that the coiled body is a kinetic nuclear structure. (springer.com)
  • disease in humans
  • Arenaviral infections are frequent causes of acute disease in humans. (mdpi.com)
  • Two cases of human disease associated with THOV occurred in 1966, and a Russian laboratory accident in the 1980s showed that DHOV can also cause disease in humans. (wikipedia.org)
  • Wagner
  • Wagner attended Columbia University as an undergraduate and received his bachelor's degree in 1943, after which he began medical school at Yale Medical School and received his M.D. in 1946. (wikipedia.org)
  • Wagner also became the director of the newly created University of Virginia Cancer Center and was appointed the Marion McNulty and Marvin C. Weaver Professor of Oncology in 1984. (wikipedia.org)
  • Wagner retired and assumed professor emeritus status at the University of Virginia in 1994, though he continued to be an active member of the community. (wikipedia.org)
  • 1999
  • Bergstrom CT, McElhany P, Real LA (1999) Transmission bottlenecks as determinants of virulence in rapidly evolving pathogens. (springer.com)
  • In 1999, Dr. Lodish also became Professor of Biological Engineering in the new MIT Department of Biological Engineering. (wikipedia.org)
  • arboviruses
  • No serological relationship of Marco virus to other arboviruses has so far been demonstrated. (ajtmh.org)
  • Thogotoviruses are distinguished from most other orthomyxoviruses by being arboviruses - viruses that are transmitted by arthropods, in this case usually ticks. (wikipedia.org)
  • type
  • 2. The process according to claim 1 , wherein said biological composition is exposed to a virucidally effective amount of artificial irradiation in the presence of a mixture of at least one quencher compound that quenches type I photodynamic reactions and at least one quencher compound that quenches type II photodynamic reactions. (google.com)
  • 4. The process according to claim 1 , wherein said biological composition is exposed to a virucidally effective amount of artificial irradiation in the presence of a quencher compound that quenches both type I and type II reactions. (google.com)
  • In particular, about 60% of HCV-infected patients present cold-precipitable (cryoprecipitable) and noncryoprecipitable immune complexes that could be associated with the clinical onset of type II mixed cryoglobulinemia (MCII) [ 2 ]. (mdpi.com)
  • It also has some similarity with the haemagglutinin of Quaranfil virus, the type species of a new genus of tick-transmitted orthomyxoviruses. (wikipedia.org)
  • cellular
  • This is due, in part, to the close structural similarity of viruses and the structure of certain essential cellular components such as ribonucleic and deoxyribonucleic acids. (patentgenius.com)
  • complement-fixation
  • Timbó and Chaco cross-react in complement-fixation testing but have not been shown to be related to any other arbovirus. (ajtmh.org)
  • The indirect fluorescant-antibody test of the patient's serum was negative to 10 Plasmodium antigens, but Babesia antibodies were demonstrated in both complement-fixation and tube latex-agglutination tests. (ajtmh.org)
  • inactivation
  • Moreover, the process can be advantageously combined with a different virucidal method to enhance virus inactivation. (google.com)
  • 1976
  • Batschelet E, Domingo E, Weissmann C (1976) The proportion of revertant and mutant phage in a growing population, as a function of mutation and growth rate. (springer.com)
  • cells
  • The modal chromosome number was 46, occurring in 70% of cells. (atcc.org)
  • a) Thin section transmission electron microscopy photomicrograph of Junín virus (JUNV) Candid#1 budding from the surface of Vero E6 cells. (mdpi.com)
  • An alternative approach to producing interferon has, therefore, been pursued, which comprisesadministering to the animal to be protected or treated a non-viral substance which stimulates--or induces--production of interferon in the cells. (patentgenius.com)
  • The plasmodia were freed from red blood cells with distilled water and then disrupted in a French pressure cell. (ajtmh.org)
  • 4) selecting or screening, in tk - IBRV host cells, for tk - IBRV from the virus produced in step (3) so as to produce an infectious bovine rhinotracheitis virus mutant which fails to produce any functional thymidine kinase as a result of an insertion in the IBRV tk gene. (google.com.au)
  • 2. The method of claim 1 wherein said method is carried out in vivo, said antigent-presenting cells are provided endogenously and said aqueous culture medium is endogenous blood or lymph. (google.com)
  • clinical
  • No vesicular lesions were observed and clinical recovery was rapid and complete. (ajtmh.org)
  • Improvement was observed in all cases, and complete clinical and parasitologic cure was obtained in 16 (80%), although the healing response was often delayed, and viable parasites were demonstrated up to 15 weeks after injection of the drug. (ajtmh.org)
  • mutants
  • She thought that these mutants played a vital role in viral pathogenesis and could possibly be used to prevent disease. (wikipedia.org)
  • Dengue
  • In 2009, a dengue outbreak (196 cases, 1 fatal) was reported - the first reports of human dengue in Senegal for two decades. (gideononline.com)
  • Italy reported a case of dengue hemorrhagic fever, imported from Senegal, and cases of dengue fever have been confirmed among French military personnel serving in this country. (gideononline.com)
  • arthropods
  • This immune evasion is important for the virus to infect systemically in vertebrates, but is unnecessary in arthropods, which lack the interferon response. (wikipedia.org)
  • Compositions
  • Methods and compositions for selectively inactivating viruses in biological compositions, including contacting the composition with an organic solvent and an ethyleneimine oligomer inactivating agent, are disclosed. (google.com)
  • This invention relates to methods and compositions for inactivating viruses in biological compositions. (google.com)
  • genome
  • Bull JJ, Badgett Mr, Rokyta D, Molineux IJ (2003) Experimental evolution yields hundreds of mutations in a functional viral genome. (springer.com)
  • JUNV is an enveloped virus with a bi-segmented negative stranded RNA genome [ 3 ]. (mdpi.com)
  • ticks
  • Semliki Forest - Semliki Forest virus has been recovered from mosquitoes (Aedes vittatus) and ticks (Rhipicephalus guilhoni) in Senegal. (gideononline.com)
  • Pat Nuttall and colleagues have speculated that the acquisition enabled these viruses to infect ticks. (wikipedia.org)
  • 1995
  • A genus of "Thogoto-like viruses" within Orthomyxoviridae was proposed in 1995, and recognised by the ICTV under the name Thogotovirus the following year. (wikipedia.org)
  • human
  • Altered enzymes in ageing human fibroblasts. (atcc.org)
  • Error theory and ageing in human diploid fibroblasts. (atcc.org)
  • Several human and monkey infections were reported in 1990. (gideononline.com)
  • A single isolated case of human Rift Valley fever was confirmed in a school teacher in Kedougou in 2012. (gideononline.com)
  • THOV, DHOV and Bourbon virus can infect humans, and have occasionally been associated with human disease. (wikipedia.org)
  • Virus infections which attack mammals, including man, are normally contagious afflictions which are capable of causing great human suffering and economic loss. (patentgenius.com)
  • pathogenesis
  • We will also summarize current knowledge on Junín virus pathogenesis focusing on the recent development of vaccines and potential therapeutics. (mdpi.com)
  • These data support a direct role of HCV in the pathogenesis of this lymphoproliferative disorder, together with the fact that 60%-80% of patients with MCII are infected with HCV and that effective anti-HCV treatment induces significant remissions of MCII [ 4 ]. (mdpi.com)
  • invention relates
  • The present invention relates to infectious bovine rhinotracheitis viruses which fail to produce any functional thymidine kinase as a result of an insertion in the thymidine kinase gene, vaccines against infectious bovine rhinotracheitis containing the same and methods for production and use of same. (google.com.au)