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  • cells
  • The plant alkaloid camptothecin (CPT) has demonstrated the ability to inhibit replication of the equine anemia virus (E1AV) and the human immunodeficiency virus (HIV) in infected cells in culture. (springer.com)
  • What they found were structures in the cytoplasm of the cells which resembled those found in virus-infested cells. (wikipedia.org)
  • Cancer Research 37 (1977): 1255-1263 "Hemoglobin Synthesis in Murine Virus-induced Leukemic Cells in Vitro: Stimulation of Erythroid Differentiation by Dimethyl Sulfoxide," with W. Scher, J.G. Holland, and T. Sato. (wikipedia.org)
  • In 1971, Dr. Friend published another landmark paper, this one titled "Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: Stimulation of erythroid differentiation by dimethyl sulfoxide. (mssm.edu)
  • This paper described research on leukemia cells that had been made to differentiate, or take another step in the maturation process to become erythroid cells, thus stopping their cancer-like multiplication. (mssm.edu)
  • however, HL60 leukemia cells treated with noncytotoxic doses of TLK199 had no alterations in growth, albeit increased basal activities of ERK and JNK ( 23 ). (aacrjournals.org)
  • In contrast, cell-mediated immune responses are important in resisting diseases caused by pathogens that live within cells, such as viruses. (encyclopedia.com)
  • mice
  • The virus infects adult immunocompetent mice and is a well-established model for studying genetic resistance to infection by an immunosuppressive retrovirus. (wikipedia.org)
  • In a study of vaccinated mice, it was possible to identify the immunological epitopes required for protection against the virus, thus determining the types of immunological responses necessary or required for protection against it. (wikipedia.org)
  • 1962 Alfred P. Sloan Award in Cancer Research 1986 Honorary Doctor of Science, Brandeis University "Cell-Free Transmission in Adult Swiss Mice of a Disease Having the Character of a Leukemia. (wikipedia.org)
  • In 1956, Dr. Friend gave a paper at the annual meeting of the American Association for Cancer Research in which she stated that she had discovered a virus that caused a leukemia-like disorder in newborn mice. (mssm.edu)
  • Rous
  • By the next year, Dr. Friend had published her work in the Journal of Experimental Medicine, under the careful editing of Peyton Rous. (mssm.edu)
  • discovery
  • She is best known for her discovery of the Friend leukemia virus. (wikipedia.org)
  • Tumor virologists additionally recognized that viruses could serve as powerful discovery tools, leading to revolutionary breakthroughs in the 1970s and 1980s that included the concept of the oncogene, the identification of the p53 tumor suppressor, and the function of the retinoblastoma tumor suppressor. (aacrjournals.org)
  • Despite the early discovery of interferon (IFN) in 1957, IFN lambdas were just identified during the recent years and classified as a new group, type III IFN. (hindawi.com)
  • Patient
  • A patient with concomitant chronic lymphocytic leukemia (CLL) and polycythemia vera (PV) requiring therapeutic phlebotomy donated a large amount of phlebotomized blood to test this possibility. (springer.com)
  • To test such an approach, we used plasma from a patient (CLL831) with concomitant B-cell chronic lymphocytic leukemia (CLL) and polycythemia vera (PV), who donated blood made available from periodic phlebotomy for PV. (springer.com)
  • known
  • The presence of blood isolate sequence 8-17 (BIS8-17) in the original plasma was confirmed by polymerase chain reaction (PCR), validating the approach, since TTV is a known plasma virus. (springer.com)
  • This virus resulted to be biologically and antigenically distinct from other known human herpesviruses [ 14 ] and was named Epstein-Barr Virus (EBV). (biomedcentral.com)
  • several
  • The decline in federal funds for basic research led Dr. Friend to write several protest letters to congressmen and others in power. (mssm.edu)
  • cell
  • Observed the relation between liver cell damage and virus release and elevation of enzyme levels. (wikipedia.org)
  • In 1966, Dr. Friend left Sloan-Kettering to become the first Director of the Center for Experimental Cell Biology and a Professor at the still developing Mount Sinai School of Medicine. (mssm.edu)
  • years
  • Dr. Friend spent the following years investigating different aspects of the virus, as did many other researchers. (mssm.edu)
  • time
  • By the time she received her doctorate in 1950, Dr. Friend already had a position in the laboratory of Dr. Alice Moore at the Sloan-Kettering Institute in New York City. (mssm.edu)