• 1960s
  • These effects were not noted in its medicinal use in the 1950s and 1960s however, and reports of physical violence on PCP have often been shown to be unfounded. (wikipedia.org)
  • The early 1960s revealed a revolutionary model by Julius Axelrod describing nerve signals and synaptic transmission, which was followed by a drastic increase of biochemical brain research into the effects of psychotropic agents on brain chemistry. (wikipedia.org)
  • mood
  • Atypical antipsychotics, however, still need to be considered powerful mood altering drugs. (winmentalhealth.com)
  • The investigations into the mechanism of activity of these agents that followed their discovery led to the proposal of the "chemical imbalance" of neurotransmitters theory of mood disorders, which is supposed to account for the pathophysiology and/or pathogenesis of these states. (wikipedia.org)
  • This has led some to question the common use of antipsychotics for the treatment of agitation in the elderly, particularly with the availability of alternatives such as mood stabilizing and antiepileptic drugs. (wikipedia.org)
  • The typical treatment for schizoaffective disorder involves the individual taking an antipsychotic drug and possibly a mood stabilizer in addition to psychoeducation. (medicinenet.com)
  • withdrawal
  • Heavy recreational use of methamphetamine may lead to a post-acute-withdrawal syndrome, which can persist for months beyond the typical withdrawal period. (wikipedia.org)
  • Introduction
  • Prior to the introduction of these agents, the management of mental disorders in America relied mainly on "psychoanalytic" methods said to be deriving from a "Freudian" understanding of the subject area. (wikipedia.org)
  • tend
  • Bipolar disorder (acute mania and mixed episodes) may be treated with either typical or atypical antipsychotics, although atypical antipsychotics are usually preferred because they tend to have more favourable adverse effect profiles and, according to a recent meta-analysis, they tend to have a lower liability for causing conversion from mania to depression. (wikipedia.org)
  • bipolar
  • Generally used only if other agents do not work, effective both for mania and refractory depression in bipolar, onset of action in mania 2 weeks and antidepressant effects 6 weeks. (studystack.com)
  • include
  • In addition to those reviewed in the following sections, atypical agents include perospirone (Sumitomo's Lullan) and zotepine (Fujisawa's Lodopin, Aventis's Nipolept, Orion Pharma' s Zoleptil, generics). (cnsdiseases.com)
  • episodes
  • He views the "hyping" of the top-selling atypical antipsychotics as "one of the more embarrassing episodes in psychiatry's history, as one government study after another failed to find that they were any better than the first-generation anti-psychotics. (wikipedia.org)