• In this review article, we outline key characteristics of major gene therapy viruses-adenovirus, adeno-associated virus (AAV), and lentivirus-and summarize the mechanisms regulating important steps in the virus journey from binding at peripheral nerve terminals to nuclear delivery. (frontiersin.org)
  • This results in catecholamines and serotonin lingering in the cytoplasm where they are destroyed by intraneuronal monoamine oxidase, thereby causing the depletion of catecholamine and serotonin stores in central and peripheral nerve terminals. (drugbank.com)
  • That sounds nice, but animal research suggests that high doses of the drug can cause the nerve endings that release serotonin to degenerate, ultimately lowering its levels in the brain. (maps.org)
  • The Bowen technique was developed in the 1950's by Thomas Ambrose Bowen of Geelong, Victoria, Australia. (bowenworkforhealing.com)
  • Mr. Bowen began developing his own technique in the 1950's, first working on his colleagues at his skilled labor job as well as athletes. (bodyswaywellness.com)
  • Nirenberg assigned him to research into the nerve endings (axons from cultured neuroblastoma cells), which he referred to as 'a truly boring project. (sunsigns.org)
  • The neurotransmitter can then cross the nerve synapse to the next nerve cell or target cell. (biologydictionary.net)
  • citation needed] Vesicles in the nerve terminal are grouped into three pools: the readily releasable pool, the recycling pool, and the reserve pool. (wikipedia.org)
  • These pools are distinguished by their function and position in the nerve terminal. (wikipedia.org)
  • These glycoproteins form membranes that fuse to release neurotransmitters from the nerve terminal. (biologydictionary.net)
  • Decompression presents a high success rate in relation to aggressive treatments, as it promotes less morbidity and preserves important structures, such as bone structures, teeth and nerve endings 1,6,11 . (bvsalud.org)
  • Sciatica happens as the sciatic nerve turns into pinched, often by a herniated disk within your spine or by an over the development of bone (aka bone spur) on the vertebrae. (trueremedies.com)
  • Whilst the symptoms of sciatica could be potentially debilitating and painful, permanent damage of sciatic nerve is rarely resulted, and spinal cord involvement can happen but rare. (trueremedies.com)
  • Rarely, the nerve could be compressed by a certain tumor or ruined by a disease like diabetes. (trueremedies.com)
  • Chaz was holding her hands, their bodies were close, and every nerve ending in her body sizzled. (nnlightsbookheaven.com)
  • The term odontogenic keratocyst was used by some authors in the mid 1950s, to describe the cystic pathology with peculiar histologic characteristics and behavior. (bvsalud.org)
  • Herein, we describe a case of a patient with KOT, in which decompression of the cystic lesion was performed for 12 months, and after it was performed the curettage followed by cryotherapy, preserving the inferior alveolar nerve, and thus, avoiding a possible pathological fracture. (bvsalud.org)
  • Every nerve ending in his body at every moment in his life has been devoted to the promotion of Alan Greenspan. (blogspot.com)
  • Thousands of nerves corresponding to body organs and tissues are concentrated in the soles of the feet called Sole Reflexive Zones (View Interactive Reflexology Chart). (happyfeet.com)
  • They activate specialized receptors or nerve endings which relay information to the brain about the condition of the body. (bodyswaywellness.com)
  • Diabetes: Sciatica affects the way that your own body uses blood sugar level, therefore increasing your potential risk of nerve damage. (trueremedies.com)
  • Kenkoh, invented in Japan in the early 1950's, is the Original Massage Sandal uniquely designed to mimic the benefits of reflexology and massage. (happyfeet.com)
  • Facial Rejuvenation hasn't been as easy, simple and fast as it has been in the early 1950s. (lifewellnessmiami.com)
  • The "G" refers to Ernst Gräfenberg, MD, a German gynecologist who is credited with "discovering" it in the 1950s, and sex experts have long touted this area of female genitalia, which is believed to contain a large number of nerve endings, as the key to helping women achieve longer and stronger orgasm. (ghanainbelgium.com)
  • This is because the area contains nerve endings and is surrounded by the clitoral network, which can lead to powerful orgasms. (tokuki.com)
  • In addition, the anal area has many highly sensitive nerve endings that can do more than just tingling. (thronesofchaos.com)
  • JEFFERSON, Iowa, May 31, 2017 - Pat Schiltz says if you weren't yet alive in the 1950s, you probably have difficulty comprehending just how frightening and widespread an epidemic of the disease polio was back then when it swept the world. (greenecountyiowahistoricalsociety.org)
  • The term sciatica mentions to symptoms of leg pain, such as numbness, tingling, or weakness, which originate in the lower back and go through the buttock and down large sciatic nerve in the back of legs. (trueremedies.com)
  • This sciatica nerve is created by the nerve roots that come out of the spinal cord into the lower back. (trueremedies.com)
  • She said that in the 1950s, "people were just a little bit hesitant to be around you if you had polio, because they weren't sure whether you'd be contagious or not. (greenecountyiowahistoricalsociety.org)
  • Alfred G. Gilman referred to the school as 'a strict, monastic, and frankly unpleasant environment in the 1950s: academic boot camp. (sunsigns.org)
  • Yes, as long as the soles of your feet are in contact with Kenkoh's massaging nodules, the nerve endings in the soles of your feet are being stimulated. (happyfeet.com)
  • Make meaningful choices in a branching narrative that leads to different endings as you try to figure out who you are, and why you're here. (pushsquare.com)
  • Depletion results in a lack of active transmitter discharge from nerve endings upon nerve depolarization, and consequently leads to a decreased heart rate and decreased arterial blood pressure as well as sedative effects 12 . (drugbank.com)
  • In the 1950s, the U.S. Army conducted research on MDMA, perhaps as a potential incapacitant or truth serum, but apparently dropped the idea. (maps.org)
  • By the 1950s, when I was on the biochemistry faculty at Baylor Med in Houston, the son, Denton Cooley, was a professor of surgery doing artificial heart research with the famous heart surgeon Michael DeBakey. (asa3.org)
  • it's like travelling to 1950s France with your pockets full of money. (thefreshfilms.com)
  • Set 60 years before the nerve-shredding events of PS4 smash hit Until Dawn, you awaken in a strange medical facility, with no memory. (pushsquare.com)
  • The procedure was based on Blaisdell's idea that internal hemorrhoids are easy to access and have few pain-sensitive nerve endings. (oregansystem.com)
  • Through her adult life, she's emphasized fitness to help cope with "nerve-ending pain and muscle pain. (greenecountyiowahistoricalsociety.org)
  • By that time I was screaming in pain from the exposed nerve in the pulp hanging down from the break. (asa3.org)
  • Sciatica is a medical condition which is tingling, pain or numbness created by irritation of nerve roots which result in sciatic nerve. (trueremedies.com)
  • Globally, tens of thousands of victims have suffered life-changing side effects, with many ending up in wheelchairs, enduring multiple organ trauma and extensive nerve damage. (spice-spotlight.scot)
  • See LOT 13455, http://www.loc.gov/pictures/item/00650023 ) The first two volumes portray ancestors, while the other volumes provide a remarkable account of her own life, primarily from the 1920s to the 1950s. (loc.gov)
  • In this procedure, a series of microinjections are strategically placed into the mesoderm, which is rich in blood vessels, lymphatic vessels, and nerve endings. (b7clinics.com)
  • Shown above is a single neuron innervating a single glomerulus from a 50-year-old human subject, with a distinctive "comet" shape comprised of a very rich periglomerular nerve arborization. (nih.gov)
  • And the ending, which is built up to be a Hitchcockian climax, lacks nerve. (thefreshfilms.com)
  • The final official addition to Rose Red was the Tower Folly, built in the 1950's. (wikiquote.org)