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  • properties
  • Its sedative properties were first published in 1869 and subsequently, because of its easy synthesis, its use was widespread. (wikipedia.org)
  • The 1950s and 1960s saw increased awareness of the addictive properties and abuse potential of barbiturates and amphetamines and led to increasing restrictions on their use and growing government oversight of prescribers. (wikipedia.org)
  • effects
  • Barbiturates are a group of central nervous system depressants which produce effects ranging from mild sedation to general anaesthesia. (europa.eu)
  • While tolerance to the sedative and intoxicating effects develops, the lethal dose is not similarly increased. (europa.eu)
  • [1-A variety of studies have demonstrated, however, that in addition to effects on the GABA A receptor, barbiturates also modulate several other ion channels, [5,including voltage-gated neuronal calcium channels. (asahq.org)
  • [17-Using CG neurons, we examined the effects of clinical concentrations of the rapidly acting barbiturates thiopental and methohexital on the depolarization-induced increase of [Ca 2+ ] i and the resulting glutamate release. (asahq.org)