Although the lanosterol 14α-demethylase is present in a wide variety of organisms, the enzyme is studied primarily in the context of fungi, where it plays an essential role in mediating membrane permeability. (wikipedia.org)
Other names in common use include obtusufoliol 14-demethylase, lanosterol 14-demethylase, lanosterol 14alpha-demethylase, and sterol 14alpha-demethylase. (wikipedia.org)
Imidazoles inhibit the enzyme lanosterol-14-α-demethylase, a cytochrome P-450-dependent enzyme that converts lanosterol to ergosterol. (davidgessner.com)
The antifungal azoles target fungal ergosterol biosynthesis by inhibiting the fungal CYP450-dependent enzyme lanosterol 14-α-demethylase, which blocks the conversion of lanosterol to ergosterol and leads to accumulation of aberrant sterol compounds and depletion of ergosterol in the fungal cell membrane. (davidgessner.com)
Azole antifungals work by inhibiting the cytochrome P450 dependent enzyme lanosterol 14-alpha-demethylase, which converts lanosterol to ergosterol, the main sterol in the fungal cell membrane. (davidgessner.com)
It inhibits the fungal lanosterol 14 alpha-demethylase which thereby prevents the formation of ergosterol which is an essential component in the fungal cell membrane. (chembase.cn)
They suppress fungal growth by acting on the heme group of lanosterol 14 alpha-demethylase enzyme (CYP51), thus blocking the biosynthesis of ergosterol. (anadolu.edu.tr)
It blocks ergosterol synthesis by inhibiting the enzyme lanosterol 14-alpha-demethylase and sterol precursor accumulation. (medscape.com)
The mechanism of action for this antifungal activity is through the decrease of ergosterol synthesis, required for membrane integrity of fungal cells, via inhibition of the lanosterol 14 alpha-demethylase (14DM) catalyst. (ecancer.org)
Histone9
Histone Deacetylase Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
This graph shows the total number of publications written about "Histone Deacetylase Inhibitors" by people in Harvard Catalyst Profiles by year, and whether "Histone Deacetylase Inhibitors" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Histone Deacetylase Inhibitors" by people in Profiles. (harvard.edu)
Nitrilase mediated mild hydrolysis of a carbon-14 nitrile for the radiosynthesis of 4-(7-hydroxycarbamoyl-[1-14 C-heptanoyl]-oxy)-benzoic acid methyl ester, [14 C]-SHP-141: A novel class I/II histone deacetylase (HDAC) inhibitor. (harvard.edu)
The impact of histone deacetylase inhibitors on immune cells and implications for cancer therapy. (harvard.edu)
This identified IOX1, a pan-histone demethylase inhibitor, which selectively downregulates α-globin expression without perturbing erythroid differentiation or general gene expression, more specifically β-like globin expression. (haematologica.org)
Lysine-specific demethylase 1 (LSD1) is a protein that modifies histone and non-histone proteins and is known to influence a wide variety of physiological processes. (biomedcentral.com)
This is the initial discovery of a histone demethylase responsible for eliminating mono- and dimethyl modifications from histones 3 lysine 4 (H3K4), histone 3 lysine 9 (H3K9), and histone 4 lysine 20 (H4K20). (biomedcentral.com)
The exact mechanism of action for luliconazole's anti-fungal activity is still not known, but luliconazole is thought to inhibit the enzyme lanosterol demethylase. (drugbank.com)
One class of drugs that explores this killing mechanism are the inhibitors of poly(ADP-ribose) polymerase (PARP) enzyme, an important DDR component. (encyclopedia.pub)
Ergosterol5
Because ergosterol constitutes a fundamental component of fungal membranes, many antifungal medications have been developed to inhibit 14α-demethylase activity and prevent the production of this key compound. (wikipedia.org)
Lanosterol demethylase is needed for the synthesis of ergosterol, which is a major component of the fungus cell membranes. (drugbank.com)
Fluconazole oral is a synthetic oral antifungal (broad-spectrum bistriazole) that selectively inhibits fungal CYP450 and sterol C-14 alpha-demethylation, which prevents conversion of lanosterol to ergosterol, thereby disrupting cellular membranes. (medscape.com)
It is a triazole antifungal agent that inhibits fungal CYP450-mediated 14 alpha-lanosterol demethylation, which is essential in fungal ergosterol biosynthesis. (medscape.com)
Fungal1
A highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethylation. (chembase.cn)
The effectiveness of imidazoles and triazoles (common azole subclasses) as inhibitors of 14α-demethylase have been confirmed through several experiments. (wikipedia.org)
20231
BRCAness as PARP Inhibitors" Encyclopedia , https://encyclopedia.pub/entry/13660 (accessed December 11, 2023). (encyclopedia.pub)
Ketorolac (Ketorolac tromethamine) is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively. (absource.de)
Amprenavir is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV. (absource.de)
NADPH1
The systematic name of this enzyme class is sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving). (wikipedia.org)
Pathway2
PARP inhibitors (PARPis) can induce synthetic lethality in cancer cells with preexistent defects in the homologous recombination (HR) repair pathway, such as deleterious mutations of the breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) suppressor genes [ 7 ] [ 8 ] . (encyclopedia.pub)
The commonness of ERα positive luminal breast cancer together with the effectiveness and widespread use of ERα pathway inhibitors in treatment predicts that this biology will remain the major focus of research and drug development. (nature.com)
Gene3
We highlight one of the most plausible associations on every single chromosome determined by mutational impact and gene annotation.Considerably Related Markers on ChromosomeThere have been two key genomic regions drastically related with tetraconazole sensitivity on chromosome 9: 13325481358331 and 1403629497163 bp ( Caspase 9 Inhibitor manufacturer supplementary table S3, Supplementary CBP/p300 Inhibitor drug Material online). (idhinhibitor.com)
The latter area notably contained a synonymous mutation (9_1451478) inside the coding area of eburicol 14-alpha demethylase CB0940_11379, otherwise generally known as the gene encoding DMI fungicide target CbCYP51. (idhinhibitor.com)
Alpha-ketoglutarate-dependent dioxygenase (ALKBH) is a DNA repair gene involved in the repair of alkylating DNA damage. (frontiersin.org)
Kinase1
Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. (drugbank.com)
Anti-inflammatory3
Design, synthesis, and anti-inflammatory activity characterization of novel brain-permeable HDAC6 inhibitors. (harvard.edu)
Ketoprofen is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains. (absource.de)
Ibuprofen (Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively. (absource.de)
Clinical2
Currently, multiple LSD1 inhibitors are undergoing clinical trials and demonstrate considerable potential in the field of cancer treatment [ 12 ]. (biomedcentral.com)
Effectiveness of triennial screening with clinical breast examination: 14-years follow-up outcomes of randomized clinical trial in Trivandrum, India. (who.int)
HDAC61
Quatramer™ mediated co-delivery of PI3-Kd/HDAC6 dual inhibitor augments the anti-cancer efficacy of Epirubicin in breast cancer. (harvard.edu)
Collectively, these alterations that mimic BRCA mutations are known as 'BRCAness' [ 14 ] . (encyclopedia.pub)
For example, bone morphogenetic protein receptor type 2 ( BMPR2 ) mutations are observed in 60-80% of familial (FPAH) cases, but data from population registries indicate that penetrance of the disease phenotype ranges from 14 to 42% [ 6 ]. (biomedcentral.com)
Alterations1
Besides, numerous published studies consistently demonstrate that epigenetic alterations have a significant impact on the reprogramming of the TME [ 14 ]. (biomedcentral.com)
Cancer1
This review examines how LSD1 modulates different cell behavior in TME and emphasizes the potential use of LSD1 inhibitors in combination with ICB therapy for future cancer research studies. (biomedcentral.com)
Treatment1
Sorafenib (Sor) is the only approved multikinase inhibitor indicated for the treatment of HCC. (biomedcentral.com)
Initially1
Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. (drugbank.com)
Human2
iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. (nature.com)
Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. (absource.de)
Years2
For pediatric patients aged 12 to 14 years weighing greater than or equal to 50 kg and those aged 15 years and older regardless of body weight use adult dosage. (nih.gov)
Comparing one dose of HPV vaccine in girls aged 9-14 years in Tanzania (DoRIS) with one dose of HPV vaccine in historical cohorts: an immunobridging analysis of a randomised controlled trial. (who.int)
Acid1
Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid. (absource.de)
People1
Below are the most recent publications written about "Cytochrome P-450 CYP2B6 Inhibitors" by people in Profiles. (uchicago.edu)
Production1
Recently, increased incidence of the pathogen on diverse crop species has been reported worldwide [ 12 - 14 ], highlighting the importance of this disease to crop production in drought prone regions. (biomedcentral.com)