• 1-Methyl-3-isobutylxanthine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • The most commonly used synthetic glucocorticoid in adipocyte differentiation procedures tends to be dexamethasone and the most commonly used phosphodiesterase inhibitor is 1-methyl-3-isobutyl-xanthine (IBMX). (wikipedia.org)
  • The 3T3 process began with cultures having 3 days to propagate on a plate (the first "3"), and then a transfer (the "T") of 300,000 cells (second "3") to a new plate to restart the process. (wikipedia.org)
  • Bone marrow mesenchymal stem cells (BMSCs) are stromal stem cells that are derived from bone marrow and possess multiplex differentiation potential ( 3 ). (researchpad.co)
  • This inhibitory effect required lower GTP[S] concentrations than the stimulatory effect (50% inhibition at 1-10 microM), and was not observed with p[NH]ppG. (ox.ac.uk)
  • A series of 1,3-dialkyluracils was of low potency as inhibitors of either peak I or peak II. (wikigenes.org)
  • This graph shows the total number of publications written about "1-Methyl-3-isobutylxanthine" by people in this website by year, and whether "1-Methyl-3-isobutylxanthine" was a major or minor topic of these publications. (wakehealth.edu)
  • Taken together, the results of our study indicate that exosomes isolated from M2 macrophages could facilitate osteogenesis and reduce adipogenesis through the miR-690/IRS-1/TAZ axis and might be a therapeutic tool for bone loss diseases. (researchpad.co)
  • M2D-Exo intervention increased the expression of miR-690, IRS-1, and TAZ in BMSCs. (researchpad.co)
  • Additionally, miR-690 knockdown in M2 macrophages with a miR-690 inhibitor partially counteracted the effect of M2D-Exos on BMSC differentiation and the upregulation of IRS-1 and TAZ expression. (researchpad.co)
  • Activation of alpha 1-adrenoceptors appears to amplify beta-adrenergic stimulation of cyclic AMP (cAMP) accumulation in rat pinealocytes severalfold by a mechanism involving activation of a Ca2+-, phospholipid-dependent protein kinase (protein kinase C). The mechanism of action of protein kinase C was investigated in this report using intact cells. (nih.gov)
  • The most commonly used synthetic glucocorticoid in adipocyte differentiation procedures tends to be dexamethasone and the most commonly used phosphodiesterase inhibitor is 1-methyl-3-isobutyl-xanthine (IBMX). (wikipedia.org)
  • To determine which factors are most important for regulation of ob mRNA expression, we examined the effects of insulin, dexamethasone, a β 3 - adrenergic agonist (CGP12177A), 8-bromo-cAMP, 8-bromo-cGMP and 1-methyl-3-isobutylxanthine (MM) on primary cultured adipocytes. (elsevierpure.com)
  • Furthermore, 954 drugs or compounds were shown to have therapeutic potential for recurrent POP, and the most critical target drugs were dexamethasone, bisphenol A, efavirenz, 1-methyl-3-isobutylxanthine, and estradiol. (bvsalud.org)
  • Moreover, insulin increased ob mRNA expression in a dose-dependent manner over a range of 1-100 nmol/l. (elsevierpure.com)
  • This stimulation represents up to 40% of the level produced by maximum activation of the arylhydrocarbon receptor (AhR) with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). (nih.gov)
  • The cAMP response following cholera toxin pretreatment (60-120 min) was rapidly and markedly enhanced by alpha 1-adrenergic agonists (cirazoline greater than PE greater than methoxamine), by phorbol esters (PMA greater than 4 beta-phorbol 12,13,-dibutyrate much greater than 4 alpha-phorbol 12,13-didecanoate), and by synthetic diacylglycerols (1,2-dioctanoylglycerol greater than 1-oleoyl 2-acetylglycerol much greater than diolein). (nih.gov)
  • The amplification of the beta-adrenergic cAMP response by these agents also occurred in the presence of isobutylmethylxanthine (10(-3) M) and Ro 20-1724 (10(-4) M), an observation suggesting that inhibition of cAMP phosphodiesterase activity is not the mechanism of action. (nih.gov)
  • EGF exerted a half-maximal reduction in depolarization-stimulated 45Ca2+ uptake at 0.1 nM and a maximal effect at 1-10 nM. (nih.gov)
  • EGF treatment increased the amount of PRL secreted basally, but inhibited the acute PRL secretory response to depolarization with 50 mM KCl and 1 microM BAY K8644 from 2.6- to 1.5-fold. (nih.gov)