• atypical
  • This line has led us to find that the 5HT2 antagonist effects of atypical antipsychotic drugs clocks nicotine-induced attentional and memory improvement. (duke.edu)
  • Here we show that dopamine-mediated enhancement of spike firing in NAcb shell medium spiny neurons was prevented by the PKC inhibitor bisindolylmaleimide but not by the phospholipase C inhibitor 1-[6-((17b-3-methoxyestra-1,3,5(10)-trien-17-yl) amino)hexyl]-1H-pyrrole-2,5-dione, suggesting a role for a diacylglycerol-independent atypical PKC (aPKC) isoform. (jneurosci.org)
  • amino
  • For experiments with bisindolylmaleimide and 1-[6-((17b-3-methoxyestra-1,3,5(10)-trien-17-yl) amino)hexyl]-1H-pyrrole-2,5-dione ( U73122 ), slices were pre-exposed for 30-60 min to enable adequate penetration, and whole-cell patch was achieved 10-15 min before dopamine application. (jneurosci.org)
  • Haloperidol
  • Reserpinization (5 mg/kg, 24 hr prior) brought about a shift towards the right, and this response was similarly blocked by haloperidol, sulpiride and yohimbine without affecting the maximum response. (pcom.edu)
  • findings
  • 5 These new data in the setting of isoflurane anesthesia are intriguing and supplement older data reporting similar findings with phenobarbital anesthesia. (asahq.org)
  • The findings suggest the presence of both D 1 and D 2 DA receptors in rat anococcygeus muscle and that DA also acts on adrenergic receptors to produce a contractile response of this muscle preparation. (pcom.edu)
  • The role of GABA A receptors is further supported by findings that GABA A antagonists can prevent these effects ( Delini-Stula, 1979 ). (aspetjournals.org)
  • Specifically
  • First, from a clinical point of view, accurate knowledge of the molecular basis for emergence from general anesthetics with agents for which no specific antagonists exists ( i.e ., inhalational agents) and for other anesthetic regimens could lead to the development of a range of new drugs specifically designed for rapid emergence. (asahq.org)
  • regulation
  • Dopaminergic neurotransmission is prominently implicated in emergence from the minimal conscious state, 1 , 2 general anesthesia, 3 and in sleep-wake regulation. (asahq.org)
  • gene
  • 5. The DNA construct as claimed in claim 1, further comprising at least one selectable marker gene, said at least one selectable marker gene being disposed within said construct so as not to disrupt expression of said DNA segment and encoding a protein conferring resistance to a selection agent. (google.com)
  • 6. The DNA construct as claimed in claim 5, wherein said selectable marker gene confers resistance to a selection agent selected from the group consisting of hygromycin, neomycin, ampicillin, spectinomycin, and streptomycin. (google.com)
  • self-administration
  • Using knockout mice, we have found that β2-containinc nicotinic receptors appear to be more important for the initiation of nicotine self-administration during the first few weeks, whereas α7 nicotinic receptors appear to be more important for the long-term consumption of nicotine over a period of 5 months. (duke.edu)
  • issue
  • This article was published in Indian journal of experimental biology , Volume 32, Issue 3, Pages 176-179. (pcom.edu)
  • cell
  • Although G αq and G α11 are expressed together in almost every cell type, the relative levels of expression vary across brain regions with G αq expression being 2-5 times higher than G α11 in most areas ( Milligan, 1993 ). (frontiersin.org)
  • response
  • α 2 antagonists yohimbine (10 -5 M) and idazoxan (10 -5 M) blocked the response to DA in a competitive manner, while α 1 antagonist prazosin (10 -5 M) completely blocked the response to DA. (pcom.edu)
  • SCH 23390 (10 -5 M), a D 1 DA antagonist potentiated the response to DA. (pcom.edu)
  • Desipramine (10 -5 M) blocked the response of DA in a non-competitive manner. (pcom.edu)