DQA1*0102:DQB1*0602 is a very common haplotype in Eurasia, with higher frequency in central Asia relative to elsewhere. (wikipedia.org)
01011
DQA1*0101 is commonly linked to haplotypes of DQB1*05, the common DQA1*0101:DQB1*0501 haplotype which is part of a broader DR1-DQ1 haplotype. (wikipedia.org)
At least two specific combinations of HLA gene variants (HLA haplotypes) have been found to increase the risk of developing celiac disease, a disorder in which inflammation damages the intestinal tract and other organs and tissues. (medlineplus.gov)
One of these haplotypes, known as DQ2, is composed of the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*05:01 or HLA-DQA1*05:05 bound to the protein produced from HLA-DQB1 gene variants known as HLA-DQB1*02:01 or HLA-DQB1*02:02 . (medlineplus.gov)
Type 1 diabetes risk is most increased by two HLA haplotypes involving variations of the HLA-DQA1 and HLA-DQB1 genes and another HLA gene called HLA-DRB1 . (medlineplus.gov)
Other HLA haplotypes only mildly increase the risk of type 1 diabetes, while some haplotypes seem to protect against developing this condition. (medlineplus.gov)
Genes4
We characterized HPV-16 variants by PCR in 107 ICC cases, which were typed for HLA-DQA1 , DRB1 and DQB1 genes and compared to 257 controls. (biomedcentral.com)
The HLA-DQA1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
The HLA-DQA1 gene belongs to a group of MHC genes called MHC class II. (medlineplus.gov)
Combinations of variations in the HLA-DQA1 gene and other HLA genes affect the risk of type 1 diabetes. (medlineplus.gov)
Variants3
Our results suggest that the association between HLA polymorphism and risk of ICC might be influenced by the distribution of HPV-16 variants. (biomedcentral.com)
The other haplotype, known as DQ8, is composed of the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*03:01 or HLA-DQA1*03:02 bound to the protein produced from the HLA-DQB1 gene variant known as HLA-DQB1*03:02 . (medlineplus.gov)
Prospective studies in larger patient populations also including novel SARS-CoV-2 variants will be required to assess the impact of HLA genetics on the capacity of mounting protective vaccination responses in the future. (biomedcentral.com)
IMGT1
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (3). (alleles.org)
Protective effect2
DQA1*0103 (*0103) shows a negative (protective) association with many autoimmune disease, this association is apparent in Japanese studies in the *0103:DQB1*0601 haplotype, and in Europe with the *0103:DQB1*0603 haplotype, indicating the protective effect is influenced by the alpha chain of DQ. (wikipedia.org)
Hierarchical testing by Cox regression analyses confirmed the significance of the protective effect of the HLA alleles identified (when assessed in composite) in terms of disease duration, whereas AB0 blood group antigen heterozygosity was found to be significantly associated with disease severity (rather than duration) in our cohort. (biomedcentral.com)
Genetics1
The goal of the current study was to assess the association of COVID-19 clinical courses controlled by patients' adaptive immune responses without progression to severe disease with patients' Human Leukocyte Antigen (HLA) genetics, AB0 blood group antigens, and the presence or absence of near-loss-of-function delta 32 deletion mutant of the C-C chemokine receptor type 5 (CCR5). (biomedcentral.com)
Class5
HLA class II polymorphisms are also associated with genetic susceptibility to ICC. (biomedcentral.com)
The protein produced from the HLA-DQA1 gene attaches (binds) to the protein produced from another MHC class II gene, HLA-DQB1 . (medlineplus.gov)
Univariate HLA analyses identified putatively protective HLA alleles (HLA class II DRB1*01:01 and HLA class I B*35:01, with a trend for DRB1*03:01). (biomedcentral.com)
Conversely, analyses also identified HLA alleles (HLA class II DQB1*03:02 und HLA class I B*15:01) not associated with such benefit in the patient cohort of this study. (biomedcentral.com)
The current study shows that the presence of HLA class II DRB1*01:01 and HLA class I B*35:01 is of even stronger association with reduced disease duration in mild and moderate COVID-19 than age or any other potential risk factor assessed. (biomedcentral.com)
Sequences2
The following sequences have been submitted to the Nomenclature Committee since the June 2017 nomenclature update and, following agreed policy, have been assigned official allele designations. (alleles.org)
a listing of recent publications that describe new HLA sequences is given in Table 3. (alleles.org)
Immune2
The HLA-DQA1 gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. (medlineplus.gov)
Association1
DQA1*0103:DQB1*0603 is part of a DR-DQ haplotype (DR13-DQ1) that increases for primary sclerosing cholangitis The same haplotype shows a negative association with rheumatic heart disease, DQA1*0104:DQB1*0503 is part of a multigene haplotype DR14-DQ5 that is associated with MuSK positive Myasthenia gravis. (wikipedia.org)
Found2
DQA1*0102:DQB1*0604 much less frequently found but spread widely. (wikipedia.org)
We observed similar proportions of HLA DRB1*1302 carriers in E-P positive cases and controls, but interestingly, this allele was not found in AA cases (p = 0.03, Fisher exact test). (biomedcentral.com)
Positive2
The serotype is positive in individuals who bear the DQA1*01 alleles. (wikipedia.org)
Compared to DQ2 serotyping of DQB1*0201 positive individuals (98%), the efficiency of DQ1 recognition is relatively low and error prone. (wikipedia.org)
Of these three serotyping specificities only DQw1 recognized DQ alpha chain. (wikipedia.org)
Since DQ1 recognizes alpha, the DQ5 and DQ6 recognition are to beta chain. (wikipedia.org)
Group1
The impact of different HLA genotypes, AB0 blood group antigens, and the CCR5 mutant CD195 were investigated for their role in the clinical course of COVID-19. (biomedcentral.com)
02012
The disease is strongly and positively associated with both HLA-DRB1*0301-DQA1*0501-DQB1*0201 (DR3-DQ2) and DRB1*04-DQA1*0301-DQB1*0302 (DR4-DQ8). (medscape.com)
Compared to DQ2 serotyping of DQB1*0201 positive individuals (98%), the efficiency of DQ1 recognition is relatively low and error prone. (wikipedia.org)
04032
On the other hand, it was observed that the DRB1*0403 subtype, which was already known to confer strong protection for T1DM, was absent among 56 DRB1*04-positive AAD patients, but present in 27% DRB1*04-positive healthy control subjects, thus also conferring protection for the development of AAD. (medscape.com)
The MHC class I chain-related gene A (MICA) allele 5.1 is strongly and positively associated with AAD. (nih.gov)
The DRB1*0401 subtype was strongly and positively associated with T1DM, but not with AAD. (medscape.com)
Gene8
Among the disease-associated gene markers is the MHC class I chain-related A ( MICA ) gene polymorphism. (medscape.com)
The MICA gene is located within the HLA class III region, although it encodes for a membrane-bound polypeptide with a predicted domain structure similar to that of the classical HLA class I chains. (medscape.com)
The HLA-DQ molecule is composed of 2 chains: DQ alpha (encoded by HLA-DQA1 gene) and DQ beta (encoded by HLA-DQB1 gene). (testcatalog.org)
The HLA-DQA1 gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
The protein produced from the HLA-DQA1 gene attaches (binds) to the protein produced from another MHC class II gene, HLA-DQB1 . (medlineplus.gov)
Researchers have identified hundreds of different versions (alleles) of the HLA-DQA1 gene, each of which is given a particular number (such as HLA-DQA1*05:01 ). (medlineplus.gov)
The other haplotype, known as DQ8, is composed of the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*03:01 or HLA-DQA1*03:02 bound to the protein produced from the HLA-DQB1 gene variant known as HLA-DQB1*03:02 . (medlineplus.gov)
Allelic1
In summary, the clinical outcome of patients with advanced MDS might be influenced by HLA allelic loss, wich allows subclonal expansions to evade cytotoxic-T and NK cell attack. (oncotarget.com)
Susceptibility2
Molecular genetic testing of first-degree relatives of a proband (including young children) to monitor those with known celiac disease-susceptibility alleles for early evidence of celiac disease in order to institute gluten-free diet early in the disease course. (nih.gov)
HLA class II polymorphisms are also associated with genetic susceptibility to ICC. (biomedcentral.com)
DQA112
The serotype is positive in individuals who bear the DQA1*01 alleles. (wikipedia.org)
DQA1*0102:DQB1*0502 has a bimodal distribution. (wikipedia.org)
DQA1*0102:DQB1*0604 much less frequently found but spread widely. (wikipedia.org)
DQA1*0103 (*0103) shows a negative (protective) association with many autoimmune disease, this association is apparent in Japanese studies in the *0103:DQB1*0601 haplotype, and in Europe with the *0103:DQB1*0603 haplotype, indicating the protective effect is influenced by the alpha chain of DQ. (wikipedia.org)
DQA1*0103:DQB1*0601 is part of a multigene haplotype (DRB1*1502:DRB5*0102:DQA1*0103:DQB1*0601:DPA1*02:DPB1*0901) linked to Takayasu's arteritis in Japanese. (wikipedia.org)
DQA1*0103:DQB1*0603 is part of a DR-DQ haplotype (DR13-DQ1) that increases for primary sclerosing cholangitis The same haplotype shows a negative association with rheumatic heart disease, DQA1*0104:DQB1*0503 is part of a multigene haplotype DR14-DQ5 that is associated with MuSK positive Myasthenia gravis. (wikipedia.org)
The current molecular method allows typing for both the DQB1 and DQA1 chains. (testcatalog.org)
In some cases, the DQ2.2 haplotype may be present with a DQ7.5 haplotype ( DQA1*05:05 with DQB1*03:01 ). (testcatalog.org)
In this case, a DQ2.5 molecule can be formed by the combination of DQB1*02:02 from one chromosome and DQA1*05:05 from the other chromosome. (testcatalog.org)
Human leukocyte antigen (HLA) haplotype DQ2 or DQ8 identified by molecular genetic testing of HLA-DQA1 and HLA-DQB1 . (nih.gov)
One haplotype, written as DRB1*03:01-DQA1*05:01-DQB1*02 , is called DR3. (medlineplus.gov)
The other haplotype, written as DRB1*04:01/02/04/05/08-DQA1*03:01-DQB1*02 , is called DR4. (medlineplus.gov)
Chromosome2
As is the case for many other autoimmune diseases, the major genetic markers associated with AAD are located in the HLA region on chromosome 6. (medscape.com)
We performed a SNP array on chromosome 6 in CD34 + purified blasts from 19 patients diagnosed with advanced MDS and 8 patients with other myeloid malignancies to evaluate the presence of loss of heterozygosity (LOH) in HLA and its impact on disease progression. (oncotarget.com)
Celiac2
Most (90%-95%) patients with celiac disease have 1 or 2 copies of HLA-DQ2 haplotype (see below), while the remainder have HLA-DQ8 haplotype. (testcatalog.org)
HLA-DQ typing can be performed by serological or molecular methods. (testcatalog.org)
HLA-DQ2 and DQ8, as typed by serology, are usually based on the molecular typing of the DQB1 chain only. (testcatalog.org)
Patients4
Some studies have focused attention on the frequency of HLA-DRB1*04 subtypes in different populations of AAD and T1DM patients, and healthy control subjects. (medscape.com)
It was observed that DRB1-*0404 was more frequent among DRB1*04-positive AAD patients from the USA [ 107 ] and Norway [ 108 ] compared with both DRB1*04-positive healthy control subjects and DRB1*04-positive T1DM patients. (medscape.com)
[ 109 ] In that study, it was observed that not statistically different distribution of DRB1*0401 and DRB1*0404 was detectable among T1DM patients and AAD patients. (medscape.com)
LOH HLA was not detected in the remaining 24 patients, who all had adverse risk factors. (oncotarget.com)
Protective1
A protective subtype may induce a deletion of autoreactive T cells more efficiently than a susceptible one or, alternatively, some DRB1*04 subtypes may present autoantigenic peptides more efficiently than others. (medscape.com)