It is commonly found in linkage disequilibration within the A*3301-Cw*0802-B*1402 haplotype which can be extended to DRB1 and DQB1 in certain instances (See Below). (wikipedia.org)
The specific nomenclature for this type is: A*3301 : C*0802 : B*1402 : DRB1*0102 : DQA1*0102 : DQB1*0501 This haplotype appears to precede A33-B58 in Asia, bringing with it the DR7-DQ2 haplotype. (wikipedia.org)
The first haplotype is A33-Cw14-B44-DR13-DQ6.4 A*3303 : C*1403 : B*4403 : DRB1*1302 : DQA1*0102 : DQB1*0604 : DPB1*0401 This haplotype is found in Japan and Korea, and it is the most common 5 locus HLA type in Korea, high at 4.2%, 25 times higher than in China. (wikipedia.org)
Within eastern Asia A*3303 is in linkage disequilibrium with on haplotype in particular, the specific genetic makeup is: A*3303 : C*0302 : B*5801 : DRB1*0301 : DQA1*0501 : DQB1*0201 It is interesting that the Cw allele in the Pakistani population is the same as the allele in the east Asian population C*0302. (wikipedia.org)
OBJECTIVE- HLA-DRB1* 03 -DQB1* 0201 /DRB1* 04 -DQB1* 0302 ( DR3/4-DQ8 ) siblings who share both major histocompatibility complex (MHC) haplotypes identical-by-descent with their proband siblings have a higher risk for type 1A diabetes than DR3/4-DQ8 siblings who do not share both MHC haplotypes identical-by-descent. (diabetesjournals.org)
Haplotypes5
These haplotypes indicate that interpreting population relationships by allele or even by low resolution haplotype information is error-prone and suggests the need for high resolution multigene haplotype studies. (wikipedia.org)
At least two specific combinations of HLA gene variants (HLA haplotypes) have been found to increase the risk of developing celiac disease, a disorder in which inflammation damages the intestinal tract and other organs and tissues. (medlineplus.gov)
One of these haplotypes, known as DQ2, is composed of the protein produced from HLA-DQB1 gene variants known as HLA-DQB1*02:01 or HLA-DQB1*02:02 bound to the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*05:01 or HLA-DQA1*05:05 . (medlineplus.gov)
Our goal was to search for non -DR/DQ MHC genetic determinants that cause the additional risk in the DR3/4-DQ8 siblings who share both MHC haplotypes. (diabetesjournals.org)
HLA- DQ2 and HLA-DQ8 testing is valuable because CD is unlikely if both haplotypes are negative. (vdocuments.net)
Genetic2
Data were technically validated using published algorithms to evaluate donor relatedness, ancestry, imputed HLA, and T1D genetic risk score. (nature.com)
During this time, the perception of CD has changed from a rather uncommon enteropathy to a common multi- organ disease with a strong genetic predisposition that is associated mainly with human leukocyte antigen (HLA)-DQ2 and HLA-DQ8. (vdocuments.net)
Genes7
The HLA-DQB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
The HLA-DQB1 gene belongs to a group of MHC genes called MHC class II. (medlineplus.gov)
Most people who have narcolepsy with cataplexy have the HLA-DQB1*06:02 variation, and many also have specific versions of other, closely related HLA genes (including HLA-DQA1 ). (medlineplus.gov)
However, these variations are very common in the general population, and only a small percentage of people with particular variations in HLA genes develop narcolepsy. (medlineplus.gov)
More than 60 genes have been identified to affect the risk of T1D, with the HLA loci having the greatest impact on susceptibility. (medcraveonline.com)
The association of T1D with alleles at HLA loci, especially the HLA class II genes DR and DQ, is well-established. (medcraveonline.com)
4 -7 These studies indicate critical and significant interactions among different genes and/or loci within or linked to the MHC or non-MHC genes. (medcraveonline.com)
Unclear2
It is unclear how HLA-DQB1*06:02 causes this elevated risk. (medlineplus.gov)
However, it is unclear how accurately the RM model reflects HLA-E immunobiology in humans. (bvsalud.org)
Haplotype3
One haplotype stands out, the A33-B58-DR3-DQ2 haplotype which is found in West Africa, in Sudan, and Pakistan, scattered along West Indias coast, the Turkic republics and appears to have recently introgressed into Korea (post-Yayoi period of Japan) and China. (wikipedia.org)
DQB1*0202 The second haplotype, like A33-B58 is found in Korea but not in Japan. (wikipedia.org)
The other haplotype, known as DQ8, is composed of the protein produced from the HLA-DQB1 gene variant known as HLA-DQB1*03:02 bound to the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*03:01 or HLA-DQA1*03:02 . (medlineplus.gov)
Antibody1
The serotype is determined by the antibody recognition of α33 subset of HLA-A α-chains. (wikipedia.org)
Risk4
A version of the HLA-DQB1 gene called HLA-DQB1*06:02 increases the risk of developing the sleep disorder narcolepsy, particularly in people who also have cataplexy. (medlineplus.gov)
To determine the effects of cytokine gene polymorphisms in the pathogenesis of T1D, high risk interferon-gamma (IFN-γ), interleukin-6 (IL-6) as well as transforming growth factor β (TGF-β) gene polymorphisms were considered in HLA DRDQ fixed patients with T1D. (medcraveonline.com)
However, a larger scale case control study is required to confirm these findings and to determine the functionality of cytokines and the high-risk HLA patients. (medcraveonline.com)
therefore, HLA is not an adequate measure to evaluate the risk of T1D. (medcraveonline.com)
Class1
The protein produced from the HLA-DQB1 gene attaches (binds) to the protein produced from another MHC class II gene, HLA-DQA1 . (medlineplus.gov)
Human2
HLA-A33 (A33) is a human leukocyte antigen serotype within HLA-A serotype group. (wikipedia.org)
For A33, the alpha "A" chain are encoded by the HLA-A*33 allele group and the β-chain are encoded by B2M locus. (wikipedia.org)
Among four groups of Mamu-E alleles: three ~5% divergent full-length allele groups (G1, G2, G2_LTR) and a fourth monomorphic group (G3) with a deletion encompassing the canonical Mamu-E exon 6, the presence of G2_LTR alleles was significantly (p = 0.02) associated with the lack of RhCMV/SIV vaccine protection. (bvsalud.org)
People1
B14 splits into B64 (B*1401) and B65 (B*1402) but the only Arabian people which show both antigens are the United Arab Emirates. (wikipedia.org)
Role1
The HLA-DQB1 gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
Human leukocy3
Glutamic acid decarboxylase 65 and islet cell antigen 512/IA-2 autoantibodies in relation to human leukocyte antigen class II DR and DQ alleles and haplotypes in type 1 diabetes mellitus. (nih.gov)
HLA-A33 (A33) is a human leukocyte antigen serotype within HLA-A serotype group. (wikipedia.org)
The HLA-DQB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
DQA18
In Korean patients, there was an association of IA-2 autoantibodies with DR4 as well as DR3, but not with DQA1*0301-DQB1*0302. (nih.gov)
GAD autoantibodies were not associated with the DR3-DQB1*0201, DQA1*0301-DQB1*0302, or DR4. (nih.gov)
The specific nomenclature for this type is: A*3301 : C*0802 : B*1402 : DRB1*0102 : DQA1*0102 : DQB1*0501 This haplotype appears to precede A33-B58 in Asia, bringing with it the DR7-DQ2 haplotype. (wikipedia.org)
The first haplotype is A33-Cw14-B44-DR13-DQ6.4 A*3303 : C*1403 : B*4403 : DRB1*1302 : DQA1*0102 : DQB1*0604 : DPB1*0401 This haplotype is found in Japan and Korea, and it is the most common 5 locus HLA type in Korea, high at 4.2%, 25 times higher than in China. (wikipedia.org)
Within eastern Asia A*3303 is in linkage disequilibrium with on haplotype in particular, the specific genetic makeup is: A*3303 : C*0302 : B*5801 : DRB1*0301 : DQA1*0501 : DQB1*0201 It is interesting that the Cw allele in the Pakistani population is the same as the allele in the east Asian population C*0302. (wikipedia.org)
The protein produced from the HLA-DQB1 gene attaches (binds) to the protein produced from another MHC class II gene, HLA-DQA1 . (medlineplus.gov)
The other haplotype, known as DQ8, is composed of the protein produced from the HLA-DQB1 gene variant known as HLA-DQB1*03:02 bound to the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*03:01 or HLA-DQA1*03:02 . (medlineplus.gov)
Most people who have narcolepsy with cataplexy have the HLA-DQB1*06:02 variation, and many also have specific versions of other, closely related HLA genes (including HLA-DQA1 ). (medlineplus.gov)
Varying HLA class1
In different populations, the immune response to different beta cell autoantigens is mediated via varying HLA class II molecules from different loci. (nih.gov)
DRB1 and DQB13
It is commonly found in linkage disequilibration within the A*3301-Cw*0802-B*1402 haplotype which can be extended to DRB1 and DQB1 in certain instances (See Below). (wikipedia.org)
Cases and controls were Emiratis and were HLA-DRB1 and -DQB1 genotyped using sequence-based typing. (bvsalud.org)
This underscores the contribution of ethnic diversity and possible diverse associations between DRB1 and DQB1 and T1D across different populations. (bvsalud.org)
Susceptibility2
The genes that confer actions, are likely to provide important information susceptibility to IDDM are located in the HLA region regarding the causes of IDDM and lead to approaches of chromosome 6. (nih.gov)
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 2007 Dec 450 (7171): 887-92. (cdc.gov)
Epitopes1
HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos. (cdc.gov)
Genotype1
Number of autoantibodies and HLA genotype, more than high titers of glutamic acid decarboxylase autoantibodies, predict insulin dependence in latent autoimmune diabetes of adults. (cdc.gov)
Autoantibodies1
In this low-risk population, autoantibodies to islet-cell antigens were associated with different HLA molecules. (nih.gov)
United Arab Emi1
B14 splits into B64 (B*1401) and B65 (B*1402) but the only Arabian people which show both antigens are the United Arab Emirates. (wikipedia.org)
Gene7
The HLA-DQB1 gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
Researchers have identified hundreds of different versions (alleles) of the HLA-DQB1 gene, each of which is given a particular number (such as HLA-DQB1*06:02 ). (medlineplus.gov)
A version of the HLA-DQB1 gene called HLA-DQB1*06:02 increases the risk of developing the sleep disorder narcolepsy, particularly in people who also have cataplexy. (medlineplus.gov)
HLA-DQ6 and ingestion of contaminated water: possible gene-environment interaction in an outbreak of Leptospirosis. (cdc.gov)
Heterogeneity in the magnitude of the insulin gene effect on HLA risk in type 1 diabetes. (cdc.gov)
Distinct tumour necrosis factor alpha, interferon gamma, interleukin 10, and cytotoxic T cell antigen 4 gene polymorphisms in disease occurrence and end stage renal disease in Wegener's granulomatosis. (cdc.gov)
Trace1
And yet there is trace DR3-DQ2 in Japanese, none in the Ainu nor many other indigenous Siberian groups. (wikipedia.org)
Immune1
The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. (medlineplus.gov)
Association2
Design of the antigen-specific immunointervention trials should take into account such HLA DR and DQ association. (nih.gov)
Results: In total, 15 DRB1 and 9 DQB1 alleles were identified in the study subjects, of which the association of DRB1*03:01, DRB1*04:02, DRB1*11:01, DRB1*16:02, and DQB1*02:01, DQB1*03:02, DQB1*03:01, and DQB1*06:01 with altered risk of T1D persisted after correcting for multiple comparisons. (bvsalud.org)