0 01 mice inbred c57bl. Medical search. Frequent questions

Inbred and outbred mouse and rat strains have very different susceptibility to Sendai virus infection. (wikipedia.org)
Treatment of both strains with exogenous IFN before and during viral infection led to an increase in survival time in C57BL/6 mice, but all animals of both strains ultimately succumb to SeV caused disease. (wikipedia.org)
Fine mapping of a major QTL influencing morphine preference in C57BL/6 and DBA/2 mice using congenic strains. (jefferson.edu)
Inbred strains of albino mice were divided into four groups and were fed with CD, HFD, GM+HFD and GM+CD. (bvsalud.org)
Bacterial strains including Bacteroides gallinarum (MT152630), Ruminococcus bromii (MT152631), Lactobacillus acidophilus (MT152632), Parabacteroides gordonii (MT152633), Prevotella copri (MT152634) and Lactobacillus gasseri (MT152635) were isolated from mice treated with GM+modified diet (HFD/CD) compared to strains Akkermansia muciniphila (MT152625), Bacteriodes sp. (bvsalud.org)
Although tumor immunosurveillance was first hypothesized more than four decades ago, the observed absence of spontaneous tumors in several immune-compromised mouse strains initially dampened enthusiasm for this idea. (silverchair.com)
The complex regulation of Na v s, together with the anatomical rostral shift of the DRG harboring injured fibers in C57BL/6 J mice, emphasize that caution is necessary and preliminary anatomical experiments should be carried out for gene and protein expression studies after SNI in mouse strains. (biomedcentral.com)
Taken together these findings suggest that animal behavior amyloid plaque deposition and AβPP processing are sensitive to genetic differences between mouse strains. (researchtoactionforum.org)

Combining data from mice and humans overcomes some of these problems, gaining power from mouse crosses and precision from human GWAS. (biomedcentral.com)
Further, this approach illustrates that the homologous mouse gene is relevant to the human phenotype, as well as the significance of experimental research in model systems that would not be possible in humans. (biomedcentral.com)

A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. (uchicago.edu)
Bessa?h T, de Yebenes EG, Kirkland K, Higley MJ, Buono RJ, Ferraro TN, Contreras D. Quantitative trait locus on distal chromosome 1 regulates the occurrence of spontaneous spike-wave discharges in DBA/2 mice. (jefferson.edu)
Herein, we describe spontaneous tumor development in gene-targeted mice lacking interferon (IFN)-γ and/or perforin (pfp), or the immunoregulatory cytokines, interleukin (IL)-12, IL-18, and tumor necrosis factor (TNF). (silverchair.com)
The relationship between the 'spontaneous' frequency of sister-chromatid exchanges (SCE) and tumorigenicity was studied in a series of hybrids between a C57BL melanoma cell line and diploid cells, but no correlation was found between the 2 variables. (biologists.com)
These are independent clonal derivatives of a spontaneous malignant melanoma tumour in the mouse. (biologists.com)

We combine the largest human GWAS of brain structure with the largest mammalian model system, the BXD recombinant inbred mouse population, to identify novel genetic targets influencing brain structure variation that are linked to increased risk for neurological disorders. (biomedcentral.com)
The use of recombinant inbred lines allows an estimate of the heritability of expression measured by individual probes. (biomedcentral.com)
Genetical genomics is further enhanced by using recombinant inbred lines as a mapping population. (biomedcentral.com)
In addition, recombinant inbred lines can provide both replicates from genetically identical individuals and samples from different segregants. (biomedcentral.com)

Chronic intermittent electronic cigarette exposure induces cardiac dysfunction and atherosclerosis in apolipoprotein-E knockout mice. (cdrewu.edu)

An inbred strain of mouse. (jefferson.edu)
CBi is an inbred mouse strain derived from an outbred population generated by crossing BALB/c, Rockland, NIH and Swiss mice. (biomedcentral.com)

We also demonstrated that human islet engraftment is improved in C57Bl/6-RAG(-/-) mice treated with liraglutide 200 microg/kg sc twice daily (P ≤ 0.05), suggesting that liraglutide should be continued after transplantation. (unige.ch)
To our knowledge, this is the first study using selected human GM transplantation via culture based method coupled dietary modulation in mice for in vivo establishment of inflammation leading to T2D and gut dysbiosis. (bvsalud.org)

The virus is responsible for a highly transmissible respiratory tract infection in mice, hamsters, guinea pigs, rats, and occasionally marmosets, with infection passing through both air and direct contact routes. (wikipedia.org)

Skeletal muscle fibrosis in the mdx/utrn+/- mouse validates its suitability as a murine model of Duchenne muscular dystrophy. (uchicago.edu)
The results obtained support the conclusion that the system M-406 plus the inbred mouse lines CBi, CBi − and CBi/L, is a good murine model to study the process of tumor immunoediting. (biomedcentral.com)
To study the consequences of sustained exposure to Ex-4, we generated metallothionein promoter-exendin-4 (MT-Exendin) mice that continuously express a proexendin-4 transgene in multiple murine tissues. (diabetesjournals.org)
SC 57461A The mouse anti-HSP70 antibody recognizes the murine form of HSP70 and detects an ~70 kDa band in immunoblots of mouse mind lysates. (researchtoactionforum.org)
The mouse anti-actin antibody recognizes the murine form of actin and detects an ~42 kDa band in immunoblots of mouse mind lysates. (researchtoactionforum.org)

Gene-targeted mice have greatly aided our understanding of the key effector molecules in tumor immunity. (silverchair.com)
references 5 , 14 , and 16 ), key molecules of both the innate and adaptive immune systems, contribute to tumor prevention in mice treated with the chemical carcinogen, methylcholanthrene (MCA), or in mice deficient for p53 expression. (silverchair.com)
When CBi mice are s.c. challenged with M-406, tumor growths exponentially in 100% of animals, while in CBi − the tumor growths briefly and then begins a rejection process in 100% of the animals. (biomedcentral.com)
In CBi/L FS mice the tumor behavior is more complex as it begins with an exponential growth pattern in all challenged mice and, after a variable length period, the tumor is completely eliminated in some individuals while in others continues growing exponentially or enters in a state of equilibrium where no additional growth is detectable. (biomedcentral.com)
A combination of HS201-PDT with anti-PD-L1 antibody demonstrated the greatest antigen-specific immune response, tumor growth suppression, prolonged mouse survival time and abscopal effect. (bmj.com)

Results Inbred C57BL/6 AβPP/PS1 mice have an earlier onset of radial-arm water maze deficits than outcrossed mice To determine if and when AβPP/PS1 mice show deficits in forebrain function we tested them at different age groups inside a radial-arm water maze using a protocol SC 57461A previously shown to detect spatial learning and research memory problems in AD transgenic mice (Alamed et al. (researchtoactionforum.org)

Five mice were selected from each group at 10 and 20 days for examination of blood cell counts, bone marrow nucleated cell counts, percentage of bone marrow CD34+ cells, bone marrow pathology, and expressions of cleaved PARP-1, cleaved caspase-3, VEGF, GPX4, and SLC7A11 in the nucleated cells. (bvsalud.org)
We now report that MT-Exendin mice develop extensive tissue lymphocytic infiltration with increased numbers of CD4 + and CD8a + cells in the liver and/or kidney and increased numbers of B220 + cells present in the pancreas and liver. (diabetesjournals.org)

Specifically, high-throughput phenotyping of 530 unique mouse gene knockouts identified 140 monogenic 'hits', of which most had no previous immunologic association. (ox.ac.uk)
Xlr genes are the mouse orthologues of the human FAM9 gene family and are implicated in the regulation of dendritic branching, dendritic spine number and morphology. (researchsquare.com)
Analysis of a quantitative trait locus for seizure susceptibility in mice using bacterial artificial chromosome-mediated gene transfer. (jefferson.edu)
Identification of five mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon. (jefferson.edu)
Production of gene-targeted mice for specific effector molecules has greatly aided this endeavor ( 4 - 14 ). (silverchair.com)
We first use a novel cross-species, comparative analysis using mouse and human genetic data to identify a candidate gene, MGST3, associated with adult hippocampus size in both systems. (biomedcentral.com)
However, the mice were grossly normal when dab2 deletion was restricted to the embryo proper and the gene was retained in extraembryonic tissues using Meox2-Cre and Sox2-Cre. (biomedcentral.com)

A study in France reported antibodies to SeV in 17% of mouse colonies examined. (wikipedia.org)
MT-Exendin mice generate antibodies directed against Ex-4, exendin NH 2 -terminal peptide (ENTP), and proexendin-4 as well as antibodies that cross-react with native GLP-1. (diabetesjournals.org)

In this study, we detected aberrant mitochondrial morphology, reduced cristae number, and large mitochondrial vacuoles from both male and female mdx mice prior to the onset of muscle damage. (frontiersin.org)
Lastly, inhibition of the strong autophagic program observed in adolescent mdx male mice via administration of the autophagy inhibitor leupeptin did not improve skeletal muscle pathology. (frontiersin.org)

CBi/L and CBi − mice were artificially selected for body conformation from CBi. (biomedcentral.com)
It was generated to be used as a base population of broad genetic basis and as the control line of an experiment of artificial body-conformation selection which gave rise, among others, to CBi − and CBi/L mice lines [ 7 , 8 ]. (biomedcentral.com)

Study design The two-bottle choice drinking assay was used to characterise aversion and preference in C57BL/6 mice to a range of menthol concentrations (10-200 µg/mL). (bmj.com)

After two months of feeding with such diets, we analyzed the mercury accumulation in tissues, the mice body growth kinetics, the possible behavioral impairments, and the concentration of neurotransmitters in various brain structures. (hindawi.com)
In this study, the effect of TWK10 on the progression of age-related impairments was investigated in mice. (frontiersin.org)
We further detected mild metabolic and mitochondrial impairments in female mdx carrier mice that were exacerbated with high-fat diet feeding. (frontiersin.org)

The virus can be detected in mouse colonies worldwide, generally in suckling to young adult mice. (wikipedia.org)

Responses were compared with those in mice deficient in the cold/menthol receptor, TRPM8, expressed in trigeminal sensory neurons innervating the oral cavity. (bmj.com)
A Protocol for Simultaneous In Vivo Imaging of Cardiac and Neuroinflammation in Dystrophin-Deficient MDX Mice Using [18F]FEPPA PET. (uchicago.edu)
Lymphomas arising in IFN-γ-deficient mice were very nonimmunogenic compared with those derived from pfp-deficient mice, suggesting a comparatively weaker immunoselection pressure by IFN-γ. (silverchair.com)
A significant incidence of late onset adenocarcinoma observed in both IFN-γ- and pfp-deficient mice indicated that some epithelial tissues were also subject to immunosurveillance. (silverchair.com)
Adult Dab2-deficient mice had a small but statistically significant increase in serum cholesterol levels. (biomedcentral.com)

OBJECTIVE: To evaluate the effect of deferoxamine (DFO) on bone marrow hematopoietic function in C57 mice exposed to a sublethal dose of X-ray irradiation. (bvsalud.org)

It was shown that resistance to the lethal effects of Sendai virus in mice is genetically controlled and expressed through control of viral replication within the first 72 hours of infection. (wikipedia.org)

Systems genetics analysis of mouse chondrocyte differentiation. (jefferson.edu)

Moreover, hEGFR KI/KI mice display accelerated chondrocyte and osteoblast differentiation, a phenotype that is also present in Egfr -/- mice and has not been previously described. (silverchair.com)

We used upstream stimulatory factor 1 (USF1) knock-out mice as a genetic model of constitutively activated BAT and positive cardiometabolic traits, and we found a reduction of depression-like and anxiety-like behaviours associated with USF1 deficiency. (researchsquare.com)
In addition, mapping studies in mouse model systems have identified genetic variants for brain structure variation with great power. (biomedcentral.com)
Prior efforts to identify genetic variants underlying differences in brain structure have used large data sets in human genome-wide association studies (GWAS) or extensive mapping populations in mouse model systems. (biomedcentral.com)

If a mouse survives a SeV infection, it develops a lifelong immunity to subsequent viral infections. (wikipedia.org)
Methods Using unilateral and bilateral implantation models of syngeneic breast tumors (E0771, MM3MG-HER2, and JC-HER3) in mice, we assessed whether HS201-PDT could induce local and systemic antitumor immunity. (bmj.com)

Surgical removal of interscapular BAT did not impact the behavioural phenotype of USF1 KO mice. (researchsquare.com)

METHODS: C57 mice exposed to a sublethal dose (5.4 Gy, 1.0 Gy/min) of total body X-ray irradiation (TBI) were treated with subcutaneous injection of 100 mg/kg DFO, with normal saline as the control, on a daily basis for 10 and 20 consecutive days. (bvsalud.org)

Each item is scored from 0 to 3, and adding the scores together gives GSK3235025 nmr a final score that ranges from 0 to 63. (c-kitinhibitors.com)

Within the forebrain we find that inbred AβPP/PS1 mice have significantly higher amyloid plaque burden at 12 months than outcrossed AβPP/PS1 mice of the same age. (researchtoactionforum.org)

The seven isolates were subsequently used as synthetic gut microbiome (GM) for their role in inducing T2D in mice. (bvsalud.org)

When presented with a highly aversive concentration of nicotine (200 µg/mL), mice preferred solutions with 50 or 100 µg/mL menthol added over nicotine alone. (bmj.com)
In contrast to wild-type mice, Trpm8−/− showed a strong aversion to mentholated (100 µg/mL) nicotine (200 µg/mL) and preferred nicotine alone. (bmj.com)
Higher levels of cotinine were detected in the mice inhaling mentholated cigarette smoke than in the mice inhaling non-mentholated smoke, implying that menthol increases nicotine uptake. (bmj.com)
A mouse model for chronic intermittent electronic cigarette exposure exhibits nicotine pharmacokinetics resembling human vapers. (cdrewu.edu)
Nicotine pretreatment reduced cocaine-induced CPP and its reinstatement in a sex- and dose-related manner in adult C57BL/6J mice. (cdrewu.edu)

The present study was designed to characterize the interaction between mammary adenocarcinoma M-406 and CBi, CBi − and CBi/L inbred mice lines. (biomedcentral.com)
The mammary adenocarcinoma M-406 developed spontaneously in a CBi mouse. (biomedcentral.com)

Mice lacking the epidermal growth factor receptor (EGFR) develop epithelial defects and a neurodegenerative disease and die within the first month of birth. (silverchair.com)

Na v s mRNA levels in mouse dorsal root ganglia (DRG) were studied in the spared nerve injury (SNI) and spinal nerve ligation (SNL) models of neuropathic pain. (biomedcentral.com)

Furthermore, lymphocytes isolated from MT-Exendin mice proliferate in response to proexendin-4 but not after exposure to Ex-4 or ENTP. (diabetesjournals.org)

In Japan intranasal Sendai virus-based SARS-CoV-2 vaccine was created and tested in a mouse model. (wikipedia.org)
The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY. (uchicago.edu)
Abstract The study was aimed to assess impact of high fat diet (HFD) and synthetic human gut microbiota (GM) combined with HFD and chow diet (CD) in inducing type-2 diabetes (T2D) using mice model. (bvsalud.org)
even Na v 1.3, known to be upregulated in rat neuropathic pain models, was lower in the SNI mouse model. (biomedcentral.com)

For the first time, we investigated the effects of acute systemic administration of nicotinic acid on sleep in mice. (nature.com)

Homozygous hEGFR KI/KI mice are viable and live up to six months. (silverchair.com)

Interestingly, the neurodegeneration is fully rescued in hEGFR KI/KI mice, however, they develop a severe heart hypertrophy with semilunar valve abnormalities. (silverchair.com)
These results are in line with previous data and suggest that before the onset of myofiber necrosis, mitochondrial and metabolic abnormalities are present within the mdx mouse. (frontiersin.org)

These findings demonstrate that expression of a proexendin-4 transgene may be associated with activation of humoral and cellular immune responses in mice. (diabetesjournals.org)

We show that the conditional depletion of the m 6 A reader protein Ythdf2 in mice causes lethality at late embryonic developmental stages, with embryos characterized by compromised neural development. (biomedcentral.com)

outcrossed AβPP/PS1 mice do not display defects until 18 months. (researchtoactionforum.org)
Surprisingly inbred AβPP/PS1 mice at 8 months have low plaque burden suggesting that plaque burden alone cannot explain the accompanying behavioral deficits. (researchtoactionforum.org)
Fig. 1 Onset of radial-arm water maze deficit happens between 16 and 18 months for outcrossed AβPP/PS1 mice and as early as 8 weeks in inbred C57BL/6 AβPP/PS1 mice. (researchtoactionforum.org)

During selection, the lines were inbred by limiting the population size [ 9 ] until an average theoretical inbreeding coefficient of approximately 0.985 was reached. (biomedcentral.com)

Collectively these data suggest that the metabolic regulator USF1 is involved in the control of affective behaviour in mice and that this modulation of mood states is unrelated to USF1-dependent BAT activation, but instead reflected in structural changes in the brain. (researchsquare.com)

However, these mice are growth retarded and show skin and hair defects similar to Egfr -/- mutants. (silverchair.com)

5 In recent studies in mice, we demonstrated that menthol inhibits the respiratory irritation response to cigarette smoke irritants such as acrolein and to cigarette smoke itself. (bmj.com)

Results Mice showed aversion to menthol concentrations of 100 µg/mL and above. (bmj.com)

Trpm8−/− mice show aversion to lower concentrations of menthol than wild-type mice. (bmj.com)

By employing a conditional knock-in approach using the human EGFR cDNA mice humanised for EGFR ( hEGFR KI/KI )were generated. (silverchair.com)
This antibody detects a ~110 kDa music group in immunoblots of transgenic AβPP/PS1 mouse human brain lysates. (researchtoactionforum.org)
This antibody also identifies the AβPP β-C-terminal fragment (~16 kDa) from detergent-extracted mouse human brain lysates. (researchtoactionforum.org)
This antibody detects the ~22 kDa PS1 C-terminal fragment SC 57461A in immunoblots of transgenic AβPP/PS1 mouse human brain lysates. (researchtoactionforum.org)

C57BL/6 mice showed slight loss of body weight after SeV administration, which returned to normal later. (wikipedia.org)
Only 10% mortality rate was observed in C57BL/6 mice after the administration of very high virulent dose of 1*105 TCID50. (wikipedia.org)

Organisms4

Chemicals and Drugs3

Phenomena and Processes1

Technology, Industry, Agriculture3

Strains8

Humans2

Spontaneous5

Recombinant inbred4

Knockout1

Strain2

Transplantation2

Rats1

Murine5

Tumor5

Transgenic Mice1

Cells2

Gene7

Antibodies2

Male2

Conformation2

Preference1

Impairments3

Young adult mice1

Deficient5

Hematopoietic1

Genetically1

Genetics1

Chondrocyte1

Genetic3

Immunity2

Phenotype1

Methods1

Ranges1

Significantly1

Microbiome1

Nicotine5

Adenocarcinoma2

Epithelial1

MRNA1

Lymphocytes1

Model4

Acute1

Viable1

Abnormalities2

Immune1

Embryos1

Months3

Population1

Control1

Defects1

Respiratory1

RESULTS1

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Human4

Administration2