• protein
  • Peloton's drug discovery and development efforts focus on identifying novel compounds capable of modulating complex protein-protein interactions that drive disease which have eluded conventional small molecule approaches. (biospace.com)
  • kidney
  • Patients 18 years of age and older with von Hippel-Lindau disease who have at least one kidney tumor large enough to pose a risk of metastasis (spread of cancer to other parts of the body) may be eligible for this study. (clinicaltrials.gov)
  • DALLAS--( BUSINESS WIRE )-- Peloton Therapeutics , Inc., announced today dosing of the first patient in a Phase 2 trial evaluating the efficacy and safety of lead investigational oncology agent, PT2977, to treat von Hippel-Lindau (VHL) disease-associated kidney cancer. (biospace.com)
  • We are excited about the opportunity to study PT2977 which may offer a new option as an orally available agent that could reduce the need and frequency of surgical intervention for patients with VHL-associated kidney disease. (biospace.com)
  • mutations
  • Approximately 20% of cases of VHL disease are found in individuals without a family history, known as de novo mutations. (wikipedia.org)
  • Genetics
  • They had two sons during their marriage, Peter Verveer Tishler, who went on to become a noted physician specializing in the genetics associated with diseases, and Carl Lewis Tishler. (wikipedia.org)
  • Approximately
  • Approximately 40% of people or families with the disease have papules in their mouth, which can be located on the cheeks (buccal mucosa), tongue, gums, or lips. (wikipedia.org)
  • oncology
  • The substrate on which the tumor condition develops (if the liver is normal or if there is evidence of diffuse liver disease) and the developing context (oncology, septic) are also added. (wikipedia.org)
  • Treatment
  • In addition to the international Phase 2 trial of PT2977 in VHL disease-associated RCC, Peloton is evaluating the agent in a Phase 1 clinical trial for the treatment of advanced RCC. (biospace.com)
  • common
  • Although all of these tumours are common in VHL disease, around half of cases present with only one tumour type. (wikipedia.org)
  • This disease is less common in younger people as it is usually a function of aging. (wikipedia.org)
  • occurs
  • Degenerative disc disease occurs over time when the discs within each vertebra in the neck begin to fall apart and begin to disintegrate. (wikipedia.org)
  • impact
  • Although VHL is a relatively rare disease, affecting 1in 32,000 people, its impact within carrier families is enormous. (massgeneral.org)