mechanical thrombectomy

  • Despite recent clinical trials demonstrating greater benefit with mechanical thrombectomy,thehigher cost associated with thrombectomy may limit its broad applicability. (
  • The probability of individual primaryendpoints was obtained from the results of the SWIFT PRIME trial that compared98 acute ischemic stroke patients who received intravenous rt-PA alone with 98 patients who had mechanical thrombectomy with IV rt-PA (combination therapy). (
  • Background and Purpose- The purpose of this study was to determine whether leukoaraiosis (LA) predicts hemorrhagic transformation and poor outcome in patients with acute ischemic stroke treated by mechanical thrombectomy. (
  • 1 , 2 An increasing number of predictors of clinical outcome and favorable revascularization in patients with AIS treated by mechanical thrombectomy have been recently reported. (
  • 3 - 6 However, predictors of hemorrhagic transformation (HT) associated with mechanical thrombectomy for AIS have not been well described. (
  • 10 - 13 However, the association of LA with HT and clinical outcome after mechanical thrombectomy is unclear. (
  • The purpose of this study was to determine whether LA confirmed on MRI before mechanical thrombectomy may predict HT and subsequent poor outcome in patients with AIS with large-vessel intracranial occlusions. (
  • All consecutive patients with AIS treated by mechanical thrombectomy with Merci Retriever devices (Concentric Medical, Inc, Mountain View, CA) from August 2002 through August 2008 were prospectively maintained in a database at the University of California at Los Angeles stroke center according to a protocol approved by the local Institutional Review Board. (
  • Individual randomized trials have shown possible benefits of mechanical thrombectomy after usual care compared with usual care alone (i.e., intravenous thrombolysis) in the management of acute ischemic stroke patients. (
  • Objectives This study systematically determined if mechanical thrombectomy after usual care would be associated with better outcomes in patients with acute ischemic stroke caused by large artery occlusion. (
  • Methods The authors included randomized trials that compared mechanical thrombectomy after usual care versus usual care alone for acute ischemic stroke. (
  • Conclusions In acute ischemic stroke due to large artery occlusion, mechanical thrombectomy after usual care was associated with improved functional outcomes compared with usual care alone, and was found to be relatively safe, with no excess in intracranial hemorrhage. (
  • There was a trend for reduction in all-cause mortality with mechanical thrombectomy. (

acute ischemic stroke

  • To determine the cost-effectiveness of stent-retriever thrombectomy plus IV-tPA versus IV-tPA alone in acute ischemic stroke patients. (
  • In acute ischemic stroke patients and major arterial occlusion, stent-retriever thrombectomy in addition to intravenous t-PA,is both cost effective and improves quality of life. (


  • Patients treated by thrombectomy were either ineligible for intravenous (IV) tissue-type plasminogen activator (tPA) or the occluded vessel failed to recanalize after receiving IV tPA (0.9 mg/kg) within 3 hours of stroke onset. (
  • In contrast, subsequent trials that used first-generation thrombectomy devices failed to demonstrate clinical benefit compared with intravenous thrombolysis (10,11) . (


  • Conclusions- Moderate or severe LA in the DWM increases the risk of parenchymal hematoma after Merci thrombectomy for patients with acute stroke. (


  • This denotes that thrombectomy along with t-PA was both cheaper as well as improved Quality of life when compared to t-PA alone. (