• MEF2
  • A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. (wikipedia.org)
  • Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. (wikipedia.org)
  • receptor
  • The constitutive active/androstane receptor (CAR) regulates hepatic drug metabolism by activating genes, such as cytochrome P450, and certain transferases. (aspetjournals.org)
  • SDF-1α was initially identified as a pre-B-cell growth-stimulating factor ( 10 ) binding a sole seven-transmembrane G protein-coupled receptor, CXCR4. (aacrjournals.org)
  • In contrast, receptor internalization is pertussis toxin insensitive, mediated by G protein-coupled receptor kinases and β-arrestin ( 19 , 24 ). (aacrjournals.org)
  • The κ-opioid receptor (KOR) is a G protein-coupled receptor that in humans is encoded by the OPRK1 gene. (wikipedia.org)
  • However, only one cDNA clone has been identified, hence these receptor subtypes likely arise from interaction of one KOR protein with other membrane associated proteins. (wikipedia.org)
  • Dynorphins exert their effects primarily through the κ-opioid receptor (KOR), a G-protein-coupled receptor. (wikipedia.org)
  • The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. (wikipedia.org)
  • The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. (wikipedia.org)
  • Since 1989 memantine has been recognized to be an uncompetitive antagonist of the N-methyl-D-aspartate receptor (NMDA receptor), entering the channel of the receptor after it has been activated and thereby blocking the flow of ions. (wikipedia.org)
  • The NMDA receptor is a glutamate and ion channel protein receptor that is activated when glycine and glutamate bind to it. (wikipedia.org)
  • The receptor is a heteromeric complex that interacts with multiple intracellular proteins by three different subunits: NR1, NR2 and NR3. (wikipedia.org)
  • mechanism
  • Based on the results of dynorphin A2-13, the authors proposed a mechanism in which dynorphin A activates bradykinin receptors and thus stimulates pain response. (wikipedia.org)
  • Although the precise mechanism by which osmotic stress is sensed by the cell is unclear, it has been suggested that Brx, a guanine nucleotide exchange factor (GEF) localized near the plasma membrane, is activated by osmotic stress through changes in the cytoskeleton structure. (wikipedia.org)
  • regulation
  • Here we hypothesize that protein phosphatases are involved in the regulation of cytokine expressions during influenza virus infection. (mdpi.com)
  • We observed an up-regulation of inducible nitric oxide synthase (iNOS), prepro endothelin-1 (preproET-1) and phosphorylated p38-MAPK in thoracic aorta and kidney cortex but not in kidney medulla in 28-days diabetes group. (ebscohost.com)
  • NaV1.6 channels demonstrate resistance against protein phosphorylation regulation. (wikipedia.org)
  • In addition to regulation through alternative splicing, the protein product is subject to post-translational modifications such as acetylation and phosphorylation. (wikipedia.org)
  • phosphatidylinositol
  • Resveratrol (3,4′,5-trihydroxy-trans-stilbene), a naturally occurring polyphenolic compound found abundantly in grape skins and red wines, has been found to pharmacologically precondition the heart against ischemia reperfusion injury through the potentiation of a survival signal involving cAMP response element-binding protein-dependent phosphatidylinositol 3-kinase-Akt-BclII pathway. (aspetjournals.org)
  • ubiquitination
  • Both ubiquitination and SUMOylation of PML protein can trigger its degradation in the proteasome, thus providing a means of modulating PML protein lability within the cell. (wikipedia.org)
  • Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. (wikipedia.org)
  • chemotaxis
  • This study suggests that signaling through p38 MAPK is required for ALL cell chemotaxis but not for proliferation, and that the loss of a chemotactic response to SDF-1α does not impede engraftment in NOD/SCID mice. (aacrjournals.org)
  • binds
  • Within the nucleus, sumoylated PML proteins multimerize with one another through interactions at the RBCC domain.This forms a ring-like structure that binds to the nuclear matrix, forming a PML-Nuclear body (PML-NB). (wikipedia.org)
  • endogenous
  • MS-275 and SAHA significantly suppressed the expression of p38α MAPK, but induced the expression of MAPK phosphatase-1 (MKP-1), an endogenous suppressor of p38α in E11 cells. (mdpi.com)
  • acute
  • These results suggest that acute application of DOX might impair the formation of LTM via the p38 MAPK pathway. (jneurosci.org)
  • ERK1
  • The cardioprotection afforded by resveratrol was partially abolished with PD98059 or SB-202190, suggesting that ERK1/2 and p38 MAPK play roles in resveratrol-mediated preconditioning. (aspetjournals.org)
  • constitutively
  • Instead, NFAT5 is a constitutively nuclear protein whose activity and localization does not depend on calcineurin-mediated dephosphorylation. (wikipedia.org)
  • Moreover
  • Moreover, MS-275 and SAHA suppressed granulocyte chemotactic protein-2 (GCP-2), monocyte chemotactic protein-2 (MCP-2) and macrophage migration inhibitory factor (MIF) in E11 cells in a concentration-dependent manner. (mdpi.com)