• Pulmonary Langerhans cell histiocytosis (pulmonary LCH) is an uncommon disorder, characterized by the accumulation of CD1a+ Langerhans cells (LCs) organized in granulomas that develop in, and destroy the wall of distal bronchioles. (clinicaltrials.gov)
  • Multiple bone lesions in keeping with Langerhans cell histiocytosis . (radiopaedia.org)
  • Langerhans cell histiocytosis may appear in a variety of ways. (scielo.br)
  • Development of nail dystrophics in Langerhans cell histiocytosis is unusual in children. (scielo.br)
  • It is possible that the main title of the report Langerhans Cell Histiocytosis is not the name you expected. (webmd.com)
  • Langerhans cell histiocytosis (LCH) is a spectrum of rare disorders characterized by overproduction (proliferation) and accumulation of a specific type of white blood cell (histiocyte) in the various tissues and organs of the body (lesions). (webmd.com)
  • Langerhans cell histiocytosis was selected by the Histiocyte Society to replace the older, less specific term histiocytosis X. Histiocytosis X encompassed three entities known as eosinophilic granuloma, Hand-Schuller-Christian disease, and Letterer-Siwe disease that were characterized by the accumulation of histiocytes. (webmd.com)
  • Langerhans cell histiocytosis was chosen because it seemed that the Langerhans cells might play a central role in the development of these disorders. (webmd.com)
  • Langerhans cell histiocytosis Langerhans cell histiocytosis is a disorder in which excess immune system cells called Langerhans cells build up in the body. (icdlist.com)
  • In Langerhans cell histiocytosis, excess immature Langerhans cells usually form tumors called granulomas. (icdlist.com)
  • However, Langerhans cell histiocytosis is not generally considered to be a form of cancer.In approximately 80 percent of affected individuals, one or more granulomas develop in the bones, causing pain and swelling. (icdlist.com)
  • Langerhans cell histiocytosis is a member of a group of rare histiocytic syndromes and is characterized for the proliferation of histiocytes called Langerhans'cells. (scielo.br)
  • Rapidly Fatal Multiorgan Langerhans Cell Histiocytosis in a Neonate. (biomedsearch.com)
  • Multiorgan Langerhans cell histiocytosis (LCH) presenting in the neonatal period is associated with a poor prognosis. (biomedsearch.com)
  • A fatal case of congenital disseminated Langerhans cell histiocytosis. (biomedsearch.com)
  • The case of a newborn male infant with congenital Langerhans cell histiocytosis (LCH) is presented. (biomedsearch.com)
  • Pulmonary Langerhans cell histiocytosis (PLCH) is proliferation of monoclonal Langerhans cells in lung interstitium and airspaces. (merckmanuals.com)
  • PLCH is one manifestation of Langerhans cell histiocytosis , which can affect organs in isolation (most notably the lungs, skin, bones, pituitary, and lymph nodes) or simultaneously. (merckmanuals.com)
  • Pulmonary Langerhans cell histiocytosis (PLCH) is a diffuse lung disease that usually affects young adult smokers. (bmj.com)


  • The lesions may include certain distinctive Langerhans cells involved in certain immune responses, as well as other white blood cells (e.g.,lymphocytes, monocytes, eosinophils). (webmd.com)


  • Abstract The presence of Fc receptors for IgE on epidermal Langerhans cells (LC) from patients with atopic dermatitis (AD) was demonstrated by three different types of experiments. (omicsonline.org)


  • PLCH is a disease in which monoclonal CD1a-positive Langerhans cells (a type of histiocyte) infiltrate the bronchioles and alveolar interstitium, accompanied by lymphocytes, plasma cells, neutrophils, and eosinophils. (merckmanuals.com)
  • The current consensus is that PLCH represents a myeloid neoplasm with inflammatory properties: the myeloid tumour cells exhibit surface CD1a expression and up to 50% of the cells harbour activating BRAF or other MAPK mutations. (bmj.com)


  • The specimen comprises sheets of histiocytic cells admixed with eosinophils, neutrophils, plasma cells and multinucleated giant cells. (radiopaedia.org)
  • Biopsy shows proliferation of Langerhans cells with occasional clustering of eosinophils (the origin of the outdated term eosinophilic granuloma) in the midst of cellular and fibrotic nodules that may take on a stellate configuration. (merckmanuals.com)


  • Your bone marrow and thymus produce the cells in lymph. (icdlist.com)


  • Immunohistochemistry shows the histiocytic cells positively stains with CD1a and S100. (radiopaedia.org)
  • 5% of CD1a cells in bronchoalveolar lavage fluid is highly suggestive of the disease. (merckmanuals.com)


  • However, new research (Allen 2010) has shown that the skin Langerhans cell is not the cell of origin, but a myeloid dendritic cell. (webmd.com)

white bloo

  • Along with your spleen, these nodes are where white blood cells fight infection. (icdlist.com)


  • Pathophysiology may involve recruitment and proliferation of Langerhans cells in response to cytokines and growth factors secreted by alveolar macrophages in response to cigarette smoke. (merckmanuals.com)