• water
  • Hydrochlorothiazide blocks the reabsorption of sodium and chloride ions, and it thereby increases the quantity of sodi-um traversing the distal tubule and the volume of water excret-ed. (nih.gov)
  • By impairing Na+ transport in the distal convoluted tubule, hydrochlorothiazide induces a natriuresis and concomitant water loss. (wikipedia.org)