Carotenoids such as beta-carotene, lycopene, lutein and beta-cryptoxanthin are produced in plants and certain bacteria, algae and fungi, where they function as accessory photosynthetic pigments and as scavengers of oxygen radicals for photoprotection. (wikipedia.org)
Yellow skin, which is a common phenotype in domestic chicken, is influenced by the accumulation of carotenoids in skin due to absence of beta-carotene dioxygenase 2 (BCDO2) enzyme. (wikipedia.org)
Animal species differ greatly in their ability to convert retinyl -beta-ionone- containing carotenoids to retinals. (openfoodfacts.org)
Provitamin A carotenoids are plant pigments that include beta-carotene, alpha-carotene, and beta-cryptoxanthin [ 1 ]. (nih.gov)
The body converts provitamin A carotenoids into vitamin A in the intestine via the beta-carotene monooxygenase type 1 BCMO1 enzyme [ 1 , 3 , 6 ], although conversion rates may have genetic variability [ 7 , 8 , 9 ]. (nih.gov)
Gene risk scores were created: five low specific-carotenoid risk scores (LSCRS: a-carotene, b-carotene, luteinþ zeaxanthin, b-cryptoxanthin and lyco- of pene) and one low total-carotenoid risk score (LTCRS: total carotenoids). (nih.gov)
Among more than forty carotenoids in the human species with various antioxidants, has been implicated in the diet, only the following five carotenoids or groups of caroten- pathogenesis of many chronic diseases, including type 2 oids have been shown to be consistently measurable in human diabetes mellitus, CVD, rheumatological disorders and serum: a-carotene, b-carotene, b-cryptoxanthin, lycopene and carcinogenesis(1). (nih.gov)
Lutein and β-carotene are carotenoids that act as vitamin A precursors to prevent collagen degradation and inflammation. (regimenlab.com)
Enzyme1
In the intestine and liver, beta carotene is converted into vitamin A by the enzyme beta-carotene-15,15′-monooxygenase (BCMO1) - a process that, when running smoothly, let's your body make retinol from plant foods like carrots and sweet potatoes. (healthline.com)
BCMO12
In meta-analyses including all three studies, the G allele at rs6564851, near the beta-carotene 15,15'-monooxygenase 1 (BCMO1) gene, was associated with higher beta-carotene (p = 1.6 x 10(-24)) and alpha-carotene (p = 0.0001) levels and lower lycopene (0.003), zeaxanthin (p = 1.3 x 10(-5)), and lutein (p = 7.3 x 10(-15)) levels, with effect sizes ranging from 0.10-0.28 SDs per allele. (nih.gov)
16. Competitive regulation of human intestinal β-carotene 15,15'-monooxygenase 1 (BCMO1) gene expression by hepatocyte nuclear factor (HNF)-1α and HNF-4α. (nih.gov)
Retinal5
EC 1.14.99.36) from animals, which cleaves beta-carotene symmetrically at the central double bond to yield two molecules of retinal. (wikipedia.org)
Apocarotenoid-15,15'-oxygenase from bacteria and cyanobacteria, which converts beta-apocarotenals rather than beta-carotene into retinal. (wikipedia.org)
Monooxigenasa que cataliza la conversión del BETA-CAROTENO en dos moléculas de RETINAL. (bvsalud.org)
A monooxygenase that catalyzes the conversion of BETA-CAROTENE into two molecules of RETINAL . (bvsalud.org)
β-Carotene is composed of two retinyl groups, and is broken down in the mucosa of the human small intestine by β-carotene 15‚15'-monooxygenase to retinal, a form of vitamin A. β-Carotene can be stored in the liver and body fat and converted to retinal as needed, thus making it a form of vitamin A for humans and some other mammals. (openfoodfacts.org)
Her major scientific focus is beta-carotene oxygenases 1 and 2 and their role in carotenoid metabolism and vitamin A biosynthesis. (nih.gov)
She is focused on the design of small molecules inhibitors for carotene oxygenases and closely related RPE65 isomerase. (nih.gov)
Dioxygenase1
Beta-carotene-9',10'-dioxygenase (BCO2) from animals, which cleaves beta-carotene asymmetrically to apo-10'-beta-carotenal and beta-ionone, the latter being converted to retinoic acid. (wikipedia.org)
Carotenoid1
The carotenes α-carotene and γ-carotene, due to their single retinyl group -β-ionone ring-, also have some vitamin A activity -though less than β-carotene-, as does the xanthophyll carotenoid β-cryptoxanthin. (openfoodfacts.org)
Biochemical evidence for the tyrosine involvement in cationic intermediate stabilization in mouse beta-carotene 15, 15'-monooxygenase"Poliakov E, Gentleman S, Chander P, Cunningham FX Jr, Grigorenko BL, Nemuhin AV, Redmond TM. (nih.gov)
Liver6
Effect of repeated ether anaesthesias on levels and stability of monooxygenase system activities of mouse liver. (unibo.it)
Stability of the microsomal monooxygenases during incubations for the liver microsomal assay with S-9 fractions of mouse liver under various inductions. (unibo.it)
Effect of repeated ether anaesthesias on the monooxygenase system of mouse liver S-9 fractions. (unibo.it)
Microsomal electron transport chain: monooxygenase activities and relationships between NADPH-cytochrome c-reductase and cytochrome P450 in mouse liver. (unibo.it)
Effect of repeated ether anesthesias on the monooxygenase system of rat liver S-9 fractions. (unibo.it)
4. The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas. (nih.gov)
Gene2
gene polymorphisms.A higher intake of preformed vitamin A, but not β-carotene, in mid-childhood is associated with higher subsequent lung function and lower risk of fixed airflow limitation and incident asthma. (essex.ac.uk)
15. Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line. (nih.gov)
Lung2
We investigated whether a higher intake of preformed vitamin A or pro-vitamin β-carotene in mid-childhood is associated with higher lung function and with asthma risk in adolescence. (nih.gov)
We investigated whether a higher intake of preformed vitamin A or provitamin β-carotene in mid-childhood is associated with higher lung function and with asthma risk in adolescence.In the Avon Longitudinal Study of Parents and Children, dietary intakes of preformed vitamin A and β-carotene equivalents were estimated by food frequency questionnaire at 7 years of age. (essex.ac.uk)
Levels1
Research additional functions of -carotene monooxygenases for regulation of xanthophylls levels in the human macula.Mentor junior staff in the laboratory. (nih.gov)
Protein2
This protein has a seven-bladed beta-propeller structure. (wikipedia.org)
Moreover, isotopic labeling and heteronuclear 13 C and 15 N spectroscopies have been utilized to identify the binding of caffeine in the pembrolizumab crystal lattice, providing molecular insights into the cocrystallization of the protein and ligand. (tuberculosistest.net)
Role1
Role of proteases on monooxygenase inactivation in mixtures of incubation for the in vitro mutagenesis test with metabolic activation. (unibo.it)
Lower1
Specifically, the a-carotene and b-cryptoxanthin LSCRS were associated with a lower odds of HDL-C dyslipidaemia. (nih.gov)
Orange2
Carotenes are also responsible for the orange -but not all of the yellow- colours in dry foliage. (openfoodfacts.org)
β-Carotene is an organic, strongly colored red-orange pigment abundant in plants and fruits. (openfoodfacts.org)
Function1
9. Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta. (nih.gov)