• gene
  • Inactivation of the beta-catenin gene within DP of fully developed hair follicles results in dramatically reduced proliferation of the progenitors and their progeny that generate the hair shaft, and, subsequently, premature induction of the destructive phase of the hair cycle. (nih.gov)
  • Gene expression analysis reveals that beta-catenin activity in the DP regulates signaling pathways, including FGF and IGF, that can mediate the DP's inductive effects. (nih.gov)
  • We have used transgenic and cell type-specific knockout strategies to determine roles for beta-catenin-regulated gene expression in normal maintenance and repair of the bronchiolar epithelium. (biomedsearch.com)
  • Regulation
  • Transgenic mice that over-expressed mutant presenilin-1 show an increase of beta-amyloid-42(43) in the brain, which suggest presenilin-1 plays an important role in beta-amyloid regulation and can be highly related to Alzheimer's disease. (wikipedia.org)
  • nucleus
  • This study also showed that signaling via the insulin/Insulin-like growth factor 1 receptor led to increased levels of HDAC7 in the cytosol than the nucleus and increased levels of active β-catenin, indicating that HDAC7 associates with β-catenin. (wikipedia.org)
  • overexpression
  • Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer. (wikipedia.org)
  • inhibit
  • Based on their observations, the researchers came to the conclusion that medications that inhibit beta-catenin could transiently interfere with memory formation after trauma, helping to prevent post-traumatic stress disorder. (medindia.net)
  • modulation
  • Another study supported the conclusion that HDAC7 and β-catenin associate together by demonstrating that HDAC7 controls endothelial cell growth through modulation of β-catenin. (wikipedia.org)
  • knockout
  • Functional knockout of beta-catenin had no impact on expression of Clara cell differentiation markers, mitotic index, or sensitivity of these cells to the Clara cell-specific toxicant, naphthalene. (biomedsearch.com)
  • interacts
  • Overall, this study demonstrated that HDAC7 once again interacts with β-catenin to keep endothelial cells in a low proliferation stage. (wikipedia.org)
  • tumor
  • According to him, when over-activated by genetic mutations, beta-catenin could drive tumor formation in several tissues, such as the colon, the skin and the kidney. (medindia.net)
  • mice
  • We found that after beta-catenin is taken out, the mice can still learn to fear the shocks. (medindia.net)
  • Transgenic expression of a CD97 in mice enhanced levels of nonphosphorylated membrane-bound β-catenin and phosphorylated Akt. (wikipedia.org)
  • Mutations
  • These disease-linked mutations result in increased production of the longer form of amyloid beta (main component of amyloid deposits found in AD brains). (wikipedia.org)
  • activity
  • Analysis of TOPGal transgene activity detected beta-catenin signaling in the steady-state and repairing bronchiolar epithelium. (biomedsearch.com)
  • One study showed that HDAC7 suppresses proliferation and β-catenin activity in chondrocytes. (wikipedia.org)
  • During chondrogenesis, HDAC7 is translocated to the cytosol to be degraded, indicating that generally HDAC7 represses β-catenin activity in chondrocytes. (wikipedia.org)
  • domain
  • As sketched above, the ARM domain of beta-catenin acts as a platform to which specific linear motifs may bind. (wikipedia.org)
  • Located in structurally diverse partners, the β-catenin binding motifs are typically disordered on their own, and typically adopt a rigid structure upon ARM domain engagement - as seen for short linear motifs. (wikipedia.org)
  • different
  • The first repeat of β-catenin (near the N-terminus) is slightly different from the others - as it has an elongated helix with a kink, formed by the fusion of helices 1 and 2. (wikipedia.org)