• Catenin beta-1, also known as β-catenin (beta-catenin), is a protein that in humans is encoded by the CTNNB1 gene. (wikipedia.org)
  • Homo sapiens catenin beta 1 (CTNNB1), transcript variant 1, mRNA. (origene.com)
  • beta-Catenin, also known as CTNNB1, is a cadherin-associated protein that is involved in the regulation of cell adhesion. (bio-techne.com)
  • We assessed CTNNB1 ( beta-catenin ) exon 3 mutations in a cohort of 11 samples of adenoid ameloblastomas from 9 patients . (bvsalud.org)
  • Loss-of-function mutations in APC or AXIN or activating mutations in the gene encoding β-catenin, CTNNB1 , lead to aberrant activation of Wnt/β-catenin signaling and have been causally linked to tumorigenesis of the colon, liver and skin [1] , [4] . (plos.org)
  • Pilomatrix carcinomas contain mutations in CTNNB1, the gene encoding beta-catenin. (medscape.com)
  • β-Catenin is a dual function protein, involved in regulation and coordination of cell-cell adhesion and gene transcription. (wikipedia.org)
  • β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. (wikipedia.org)
  • It is a member of the catenin protein family and homologous to γ-catenin, also known as plakoglobin. (wikipedia.org)
  • β-Catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. (wikipedia.org)
  • β-Catenin was initially discovered in the early 1990s as a component of a mammalian cell adhesion complex: a protein responsible for cytoplasmatic anchoring of cadherins. (wikipedia.org)
  • But very soon, it was realized that the Drosophila protein armadillo - implicated in mediating the morphogenic effects of Wingless/Wnt - is homologous to the mammalian β-catenin, not just in structure but also in function. (wikipedia.org)
  • Thus, β-catenin became one of the first examples of moonlighting: a protein performing more than one radically different cellular function. (wikipedia.org)
  • Researchers reveal a new way in which cells restrain beta-catenin and potentially suppress tumor metastasis: the protein can be ejected from cells in small vesicles called exosomes. (eurekalert.org)
  • Overexpressing CD82 or CD9, members of the tetraspanin family of transmembrane proteins, suppressed Wnt signaling and reduced beta-catenin protein levels. (eurekalert.org)
  • The team found that CD9 and CD82 boosted the release of exosomes containing beta-catenin, thereby reducing cellular levels of the protein and inhibiting the Wnt pathway. (eurekalert.org)
  • β-Catenin is a fascinating protein with many important cellular and developmental functions. (chemdiv.com)
  • The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
  • β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)
  • This library represents a selection of drug-like compounds aimed at modulating protein-protein interaction (PPI) of β-catenin with different proteins involved in significant physiological processes. (chemdiv.com)
  • 5 mm in diameter were used for the analysis of beta-catenin gene mutation and beta-catenin protein expression. (nih.gov)
  • β-Catenin is a 92-kDa protein, originally identified in cell adherens junctions (AJs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. (ptglab.com)
  • Scholars@Duke publication: Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. (duke.edu)
  • Using a directed RNAi screen we find that protein phosphatase 1 (PP1), a ubiquitous serine/threonine phosphatase, is a novel potent positive physiologic regulator of the Wnt/beta-catenin signaling pathway. (duke.edu)
  • Nefopam targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo. (dcchemicals.com)
  • ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein−protein interaction (β catenin/BCL9 PPI) inhibitor. (dcchemicals.com)
  • Mutagenesis experiments demonstrate that substitution of the serine residues in the glycogen synthase kinase 3beta (GSK3beta) phosphorylation consensus motif of beta-catenin inhibits ubiquitination and results in stabilization of the protein. (bioseek.eu)
  • The LAP [leucine-rich and postsynaptic density-95/Discs large/zona occludens-1 (PDZ)] protein erbin and δ-catenin, a component of the cadherin-catenin cell adhesion complex, are highly expressed in neurons and associate through PDZ-mediated interaction, but have incompletely characterized neuronal functions. (jneurosci.org)
  • However, some tumours also showed nuclear staining of beta-catenin protein. (ox.ac.uk)
  • Our results also suggest that decreased membranous expression of beta-catenin may result from aberrant localisation of the protein in the cell nucleus. (ox.ac.uk)
  • In addition, we demonstrate that this family is critical in maintaining stemness of EpCAM + AFP + HepCSCs, in part by directly targeting an inhibitor of Wnt/β-catenin signaling (nemo-like kinase [NLK]) and two hepatic transcriptional regulators of differentiation, i.e., caudal type homeobox transcription factor 2 (CDX2) and GATA binding protein 6 (GATA6). (biomedcentral.com)
  • The canonical pathway will be the only 1 to involve beta-catenin, which can be the TCF/LEF binding protein responsible for improved transcription and EMT [57,58]. (scdinhibitor.com)
  • β-catenin protein is an integral part of the canonical Wnt signaling pathway. (tocris.com)
  • Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer. (wikipedia.org)
  • Mutations in the beta-catenin gene were detected in 8 of 24 HCCs (33.3%) in the DEN alone group, 7 of 15 HCCs (46.7%) in the DEN + AUR (initiation feeding) group, and 0 of 8 HCCs (0%) in the DENright curved arrow AUR (post-initiation feeding) group. (nih.gov)
  • No mutations of beta-catenin gene were detected in liver cell adenomas of any group. (nih.gov)
  • In conclusion, our data showed that β-catenin expression in fibroids occurs independently of MED12 mutations. (embies.com)
  • Adenoid ameloblastoma harbors beta-catenin mutations. (bvsalud.org)
  • In the 6 mutation -positive samples, ghost cells were present in only 2/6, indicating beta-catenin mutations are not always revealed by ghost cell formation. (bvsalud.org)
  • Although mutations in these same genes have not been observed as recurrent genetic events in breast tumors, there is strong evidence implicating Wnt/β-catenin activity in breast tumorigenesis. (plos.org)
  • Mutations in β-catenin, axin and APC have been discovered in numerous cancers, and other members of the canonical pathway may also contribute to misregulation of Wnt signaling. (tocris.com)
  • No. But what we do see is that in patients with low TMB and low interferon gamma, there were mutations in the Wnt signaling pathway and beta-catenin, which we know bodes a poor outcome. (medscape.com)
  • Chan EF, Gat U, McNiff JM, Fuchs E. A common human skin tumour is caused by activating mutations in beta-catenin. (medscape.com)
  • PP1 expression synergistically activates, and inhibition of PP1 inhibits, Wnt/beta-catenin signaling in Drosophila and mammalian cells as well as in Xenopus embryos. (duke.edu)
  • E-7386 (E7386) is a potent, orally active modulator of CBP/beta-catenin, disrupts the interaction and inhibits canonical Wnt signaling pathway /TCF reporter gene activity in LiCl-stimulated HEK-293 and MDA-MB-231 with IC50 of 55 and 73 nM, respectively. (dcchemicals.com)
  • ZW4864 (free base) inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM. (dcchemicals.com)
  • Depletion of CKIalpha inhibits beta-catenin phosphorylation and degradation and causes abnormal embryogenesis associated with excessive Wnt/beta-catenin signaling. (bioseek.eu)
  • Degradation of β-catenin is thus mediated by this N-terminal segment. (wikipedia.org)
  • However, how the beta-catenin degradation complex is inhibited upon Wnt activation remains unclear. (duke.edu)
  • This motif in beta-catenin resembles a motif in IkappaB (inhibitor of NFkappaB) which is required for the phosphorylation-dependent degradation of IkappaB via the ubiquitin-proteasome pathway. (bioseek.eu)
  • We show that ubiquitination of beta-catenin is greatly reduced in Wnt-expressing cells, providing the first evidence that the ubiquitin-proteasome degradation pathway may act downstream of GSK3beta in the regulation of beta-catenin. (bioseek.eu)
  • Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. (bioseek.eu)
  • Wnt regulation of beta-catenin degradation is essential for development and carcinogenesis. (bioseek.eu)
  • beta-catenin degradation is initiated upon amino-terminal serine/threonine phosphorylation, which is believed to be performed by glycogen synthase kinase-3 (GSK-3) in complex with tumor suppressor proteins Axin and adnomatous polyposis coli (APC). (bioseek.eu)
  • In the absence of Wnt ligands, a complex containing APC, AXIN and GSK3 phosphorylates β-catenin, marking it as a substrate for ubiquitination by β-TrCP and subsequent proteasomal degradation. (plos.org)
  • In addition to ligand-regulated degradation of β-catenin, Wnt signaling is antagonized by extracellular factors that inhibit the ability of Wnt ligands to bind to Fzd and initiate signaling, such as the secreted frizzled-related proteins (SFRP1, WNT inhibitory factor (WIF) and dickkopf (DKK) [3] . (plos.org)
  • Nuclear beta-Catenin activates the TCF/LEF family of transcription factors, inducing the transcription of pro-mitotic genes. (bio-techne.com)
  • We hypothesized that Wnt/β-catenin signaling transcriptionally activates microRNA-181s in HCC. (biomedcentral.com)
  • The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation. (uchicago.edu)
  • In Cyclin A2-depleted normal murine mammary gland (NMuMG) cells expressing RasV12, we found that beta-catenin was liberated from the cell membrane and cell-cell junctions and underwent nuclear translocation and activation. (cnrs.fr)
  • We found that beta-catenin expression was undetectable in SMCs of normal arteries. (yu.edu)
  • Inhibition of PP1 leads to enhanced phosphorylation of specific sites on axin by casein kinase I. Axin phosphorylation markedly enhances the binding of glycogen synthase kinase 3, leading to a more active beta-catenin destruction complex. (duke.edu)
  • Wnt-regulated changes in axin phosphorylation, mediated by PP1, may therefore determine beta-catenin transcriptional activity. (duke.edu)
  • Here we describe another Axin-associated kinase, whose phosphorylation of beta-catenin precedes and is required for subsequent GSK-3 phosphorylation of beta-catenin. (bioseek.eu)
  • Our study uncovers distinct roles and steps of beta-catenin phosphorylation, identifies CKIalpha as a component in Wnt/beta-catenin signaling, and has implications to pathogenesis/therapeutics of human cancers and diabetes. (bioseek.eu)
  • Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the catenin family. (nih.gov)
  • In the current model of this pathway, the amount of beta-catenin (or its invertebrate homolog Armadillo) is tightly regulated and its steady-state level outside the cadherin-catenin complex is low in the absence of Wingless/Wnt signal. (bioseek.eu)
  • Interestingly, beta-catenin inhibited p53 transcriptional activity in SMCs in culture and in vivo, as concurrent loss of p53 improved arterial morphogenesis and embryonic development. (yu.edu)
  • To test whether miR-181s were transcriptional targets of Wnt/β-catenin, we first examined the expression of β-catenin and miR-181s in five different HCC cell lines. (biomedcentral.com)
  • Studies have shown that the Wnt/β-catenin signaling pathway controls cell fate and function through the transcriptional and post-translational regulation of omics networks. (frontiersin.org)
  • Wnt/β-catenin signaling is a branch of a functional network that is involved in a broad range of biological systems including stem cells, embryonic development and adult organs. (chemdiv.com)
  • Besides its essential role in the AJs, β-catenin is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. (ptglab.com)
  • The Wnt/β-catenin pathway plays a critical role in embryonic development, maintenance of multipotent progenitor cell populations and proliferation of many tissue types [1] , [2] . (plos.org)
  • The beta-catenin destruction complicated starts using the binding of GSK3 to Axin, which leaves GSK3's active website open to phosphorylate beta-catenin. (scdinhibitor.com)
  • La vía de señalización se inicia con la unión de las PROTEÍNAS WNT a la superficie de las células de los RECEPTORES WNT que interactúan con el COMPLEJO DE SEÑALIZACIÓN AXIN y una serie de segundos mensajeros que influyen en las acciones de la BETA-CATENINA. (bvsalud.org)
  • The signaling pathway is initiated by the binding of WNT PROTEINS to cell surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN. (bvsalud.org)
  • Speaking more specifically, β-catenin is an integral structural component of cadherin-based adhesive junctions as well as it a key nuclear effector of canonical in nucleus Wnt signaling. (chemdiv.com)
  • The Wnt pathway mediates the biological processes of the canonical or non-canonical pathway, depending on the involvement of β-catenin in signal transduction. (chemdiv.com)
  • LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM. (dcchemicals.com)
  • Recent studies showed that genetic aberrations in the MED12 gene, probably through the canonical WNT/β-catenin pathway, lead to the pathogenesis of uterine fibroids. (embies.com)
  • Canonical Wnt/β-catenin signaling is initiated by binding of Wnt ligands to Frizzled (Fzd)-LRP5/6 receptor complexes, leading to inactivation of the destruction complex and stabilization of β-catenin. (plos.org)
  • The three pathways will be the canonical Wnt/beta-catenin pathway, the noncanonical planar cell polarity (PCP) pathway, along with the noncanonical Wnt/calcium pathway. (scdinhibitor.com)
  • The canonical Wnt pathway contains the beta-catenin destruction complex, which is normally down-regulated or disrupted following the activation of Wnt signaling. (scdinhibitor.com)
  • The dendritic phenotype observed after erbin depletion is rescued by overexpression of δ-catenin and requires a domain in δ-catenin that has been shown to regulate dendritic branching. (jneurosci.org)
  • Knockdown of δ-catenin cannot be rescued by overexpression of erbin, indicating that erbin is upstream of δ-catenin. (jneurosci.org)
  • MicroRNA-181 expression could be directly induced upon an activation of Wnt/β-catenin signaling, which includes Wnt10B overexpression, inhibition of GSK3β signaling by LiCl, or forced expression of β-catenin/Tcf4. (biomedcentral.com)
  • Alteration of beta-catenin expression in hepatocellular carcinomas (HCCs) may play an important role in tumor progression by stimulating cell proliferation. (nih.gov)
  • Not only their ARM domains resemble each other in both architecture and ligand binding capacity, but the N-terminal β-TrCP-binding motif is also conserved in plakoglobin, implying common ancestry and shared regulation with β-catenin. (wikipedia.org)
  • The recently described role of the Wnt/β-catenin pathway in the regulation of immune cell infiltration of microenvironment tumor resumes interest because of its potential impact to rection of immune therapy. (chemdiv.com)
  • Here we show that the ubiquitin-dependent proteolysis system is involved in the regulation of beta-catenin turnover. (bioseek.eu)
  • Therefore, precise regulation of Wnt/β-catenin signaling as a cancer-targeting strategy may contribute to the treatment of some malignancies. (frontiersin.org)
  • Here, we review the complex regulation of Wnt/β-catenin signaling by SUMOylation and discuss the potential targets of SUMOylation therapy. (frontiersin.org)
  • Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-beta Catenin (phospho Ser37) antibody ARG51710 (left) or the same antibody preincubated with blocking peptide (right). (bio-connect.nl)
  • To investigate alterations of beta-catenin in the development of colorectal carcinoma, the pattern of beta-catenin expression was studied using immunohistochemistry in 74 sporadic colorectal adenomas, in histologically normal mucosa adjacent to 65 of these adenomas, and in 52 carcinomas arising in adenomas. (ox.ac.uk)
  • Liquid chromatography-mass spectrometry (LC-MS), Western blotting and immunohistochemistry were used to monitor the expression of β-catenin. (embies.com)
  • Tumours from 557 incident cases of CRC, assembled in tissue microarrays, were evaluated for expression of cyclin D1, mismatch repair proteins, beta-catenin and epidermal growth factor receptor (EGFR) by immunohistochemistry, and further, EGFR gene copy number (GCN) alterations by brightfield double-in situ hybridization. (lu.se)
  • iCRT3 is an inhibitor of both Wnt and β-catenin-responsive transcription. (dcchemicals.com)
  • KYA1797K is a highly potent and selective Wnt/β-catenin inhibitor with IC50 of 0.75 µM (TOPflash assay). (dcchemicals.com)
  • PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC50 of 129.8 μM in NCI-H295 cell. (dcchemicals.com)
  • CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus. (dcchemicals.com)
  • β-catenin-IN-2 is a potent β-catenin inhibitor, compound H1B1, extracted from patent US20150374662A1. (dcchemicals.com)
  • PRI-724 (C-82 prodrug, ICG-001 analog) is a potent and specific inhibitor that disrupts the interaction of β-catenin and CBP. (dcchemicals.com)
  • GB1874 is an inhibitor of the Wnt pathway that targets the β-catenin-TCF4 interaction.GB1874 affected the proliferation and stemness of Wnt-addicted colorectal cancer (CRC) cells in vitro.GB1874 inhibited the growth of CRC tumor xenografts in vivo. (dcchemicals.com)
  • To enhance the benefit of TMZ and avoid therapeutic resistance, effective combination strategies were tested using a small molecule inhibitor blocking the Wnt/β-catenin pathway in addition to TMZ. (nature.com)
  • IWP 4 is a potent inhibitor of Wnt/ β -catenin signaling (IC 50 = 25 nM). (rndsystems.com)
  • Immunofluorescent analysis of (-20°C Methanol) fixed MCF-7 cells using CoraLite®555 Beta Catenin antibody (CL555-51067) at dilution of 1:100. (ptglab.com)
  • Immunofluorescent analysis of (4% PFA) fixed human liver cancer tissue using CoraLite®555 Beta Catenin antibody (CL555-51067) at dilution of 1:100, CoraLite® Plus 647 CD3 antibody (CL647-60181, Clone: 3F3A1, Magenta), CoraLite® Plus 488 CD163 antibody (CL488-16646, green). (ptglab.com)
  • Catenin, beta [Polyclonal] Antibody (cGMP). (enquirebio.com)
  • Using autochthonous mouse melanoma models we identified the mechanism by which tumour-intrinsic active β-catenin signalling results in T-cell exclusion and resistance to anti-PD-L1/anti-CTLA-4 monoclonal antibody therapy. (nih.gov)
  • Beta-catenin is a central component of the Wnt signaling pathway that controls cell proliferation and differentiation. (eurekalert.org)
  • The Wnt/beta-catenin signaling pathway is critical in both cellular proliferation and organismal development. (duke.edu)
  • beta-catenin is a central component of the cadherin cell adhesion complex and plays an essential role in the Wingless/Wnt signaling pathway. (bioseek.eu)
  • Taken together, our results demonstrate that microRNA-181s are transcriptionally activated by the Wnt/beta-catenin signaling pathway in HCC. (biomedcentral.com)
  • Abnormally activated Wnt/β-catenin signaling pathway plays a crucial role in promoting malignant tumor occurrence, development, recurrence, and metastasis, particularly in cancer stem cells. (frontiersin.org)
  • SUMOylation is a post-translational modification of proteins that has been found to play a major role in the Wnt/β-catenin signaling pathway. (frontiersin.org)
  • Following the first member of the Wnt family identified over the last four decades ( 25 ), several recent studies have focused on the Wnt/β-catenin signaling pathway ( 26 , 27 ). (frontiersin.org)
  • Surprisingly, this decrease did not involve an established pathway of beta-catenin destruction. (eurekalert.org)
  • Intracellular beta-catenin levels are maintained through continuous creation and destruction, the processes of that are suggested to be regulated differently in between our parity groups. (scdinhibitor.com)
  • Our evaluation showed an increased methylation of LRP5 within parous females, which suggests a decreased expression of LRP5/6 plus a decreased cellular capability to stop the beta-catenin destruction complex within this way. (scdinhibitor.com)
  • This suggests a rise in expression of GSK3 within parous females and subsequently a rise within the activity of the beta-catenin destruction complicated. (scdinhibitor.com)
  • these in turn inhibit the destruction complex responsible for degrading β-catenin, which includes GSK-3 . (tocris.com)
  • Exosomal release of beta-catenin and inhibition of Wnt signaling may explain why CD82 and CD9 suppress tumor metastasis. (eurekalert.org)
  • CD82 may act as a metastasis suppressor by targeting beta-catenin for exosomal release and thereby reducing its availability as a Wnt signaling mediator," Caplan proposes. (eurekalert.org)
  • An imbalance in the structural and signaling properties of β-catenin often leads to disease and unregulated growth associated with cancer and metastasis. (chemdiv.com)
  • In addition, Wnt/β-catenin has emerged as a critical regulator of cancer stem cells (CSCs), which is considered one of the root causes of cancer recurrence and metastasis because of their heterogeneity and plasticity ( 13 ). (frontiersin.org)
  • The molecular weight of proteins were 102, 88 and 80 kDa, so they were named α, β and γ-catenin. (chemdiv.com)
  • Proteins associated with the Wnt/β-catenin pathway have been identified as SUMOylated substrates, and evidences suggested that the initiation and progression of cancers depended on the function of the SUMOylation ( 23 ). (frontiersin.org)
  • Furthermore, the Wnt/β-catenin can crosstalk with other signaling pathways including Notch, FGF, Hedgehog, and TGF-β/BMP signaling cascades to form a signaling network to regulate the survival and progression of cancer cells ( 14 - 16 ). (frontiersin.org)
  • Wnt/β-catenin signaling is a delicate and complex signal transduction pathway mediated by multiple signaling molecules, which plays a significant role in regulating human physiology and pathology. (frontiersin.org)
  • Corrigendum to Lysine 394 is a novel Rad6B-induced ubiquitination site on beta-catenin [Biochim. (elsevierpure.com)
  • Notably, the C-terminal segment of β-catenin can mimic the effects of the entire Wnt pathway if artificially fused to the DNA binding domain of LEF1 transcription factor. (wikipedia.org)
  • ICG-001 is a small-molecule antagonist of b-catenin/TCF-mediated transcription (IC50 = 3 uM) and specifically downregulates the expression of a subset of b-catenin/TCF-responsive genes. (dcchemicals.com)
  • Here we identify CSNK1E , the gene encoding casein kinase 1 epsilon (CK1ε) as required specifically for the proliferation of breast cancer cells with activated β-catenin and confirm its role as a positive regulator of β-catenin-driven transcription. (plos.org)
  • Once stabilized, β-catenin accumulates and translocates to the nucleus, where it complexes with TCF/LEF to activate transcription of target genes, such as MYC and CCND1 . (plos.org)
  • Accumulation of β-catenin in the cell cytoplasm prompts its translocation to the nucleus, where it interacts with members of the TCF/LEF family of transcription factors and induces the transcription of Wnt target genes. (tocris.com)
  • Kajino Y, Yamaguchi A, Hashimoto N, Matsuura A, Sato N, Kikuchi K. beta-Catenin gene mutation in human hair follicle-related tumors. (medscape.com)
  • The exosomal release of beta-catenin may be compromised in certain cancers, where Wnt signaling is often hyperactive. (eurekalert.org)
  • Deregulation of components involved in Wnt/β-catenin signaling has been implicated in a wide spectrum of diseases including a number of cancers and degenerative diseases. (chemdiv.com)
  • These studies identify CK1ε as a critical contributor to activated β-catenin signaling in cancer and suggest it may provide a potential therapeutic target for cancers that harbor active β-catenin. (plos.org)
  • Uclear beta-catenin in about 60 of breast cancers. (scdinhibitor.com)
  • Aberrant TCF-β-catenin signaling is also evident in many cancers, and results in altered expression of genes controlling cell proliferation, differentiation, migration and apoptosis. (tocris.com)
  • β-catenin is a multipurpose and evolutionarily conserved molecule that plays a critical role by metazoans in a variety of processes in development and homeostasis. (chemdiv.com)
  • We found that complete loss of beta-catenin in SMCs in the mouse decreased their proliferation and survival, limited arterial wall formation, and caused embryonic lethality. (yu.edu)
  • and in this context, loss of beta-catenin in SMCs significantly reduced cell proliferation and survival in the neointima and limited neointimal growth. (yu.edu)
  • Altogether, our developmental and adult mouse studies show that beta-catenin signaling function, especially that mediated by its C-terminal domain, promotes proliferation and survival of vascular SMCs in vivo, in part by repressing p53 activity in these cells. (yu.edu)
  • The data confirm that reduced membranous and increased nuclear expression of beta-catenin is associated with the progression of colorectal adenomas to carcinomas. (ox.ac.uk)
  • ChemDiv proposes the new library of beta-catenin inhibitors/modulators. (chemdiv.com)
  • Specific inhibition of PP1 in this pathway may offer therapeutic approaches to disorders with increased beta-catenin signaling. (duke.edu)
  • β-catenin is a component of the complex cadherin complex whose stabilization is required to activate Wnt/β-catenin signaling. (chemdiv.com)
  • beta-catenin, but not E-cadherin, p120(cas) or alpha-catenin, becomes stabilized when proteasome-mediated proteolysis is inhibited and this leads to the accumulation of multi-ubiquitinated forms of beta-catenin. (bioseek.eu)
  • beta-Catenin has a central role not only in linking the cadherin-mediated cell adhesion system but also in the intercellular signalling pathway. (ox.ac.uk)
  • β-catenin also plays an essential role in cell-cell adhesion, and is thought to maintain the attachment of stem cells to their niche by interacting with membrane-bound cadherin and α-catenin. (tocris.com)
  • In addition, seven putative β-catenin/Tcf4 binding sites were identified in the promoter region of the microRNA-181a-2 and microRNA-181b-2 transcripts. (biomedcentral.com)
  • δ-Catenin belongs to the p120 catenin (p120ctn) family of catenins and binds to the cytoplasmic domains of type 1 and 2 cadherins at a membrane proximal region that is not involved in binding of either β-catenin or plakoglobin. (jneurosci.org)
  • These results demonstrate that AUR exposure in post-initiation period suppresses the occurrence of HCCs with beta-catenin mutation, presumably by negative selection for neoplastic cells harboring the mutation. (nih.gov)
  • However, β-catenin expression showed no correlation with MED12 mutation status. (embies.com)
  • Together with the absence of BRAF mutation , the detection of beta-catenin mutation in adenoid ameloblastomas supports its classification as a separate entity, and not as a subtype of ameloblastoma . (bvsalud.org)
  • The Wnt/β-catenin pathway is also involved in the activation of other intracellular messengers such as calcium fluxes, JNK, and SRC kinases. (ptglab.com)
  • After PCR amplification of exon 2 of the beta-catenin gene, the products were sequenced directly. (nih.gov)
  • ChemDiv's Inhibitors of beta-Catenin Signaling Library contains 8,000 compounds. (chemdiv.com)
  • Plakoglobin (also called γ-catenin) has a strikingly similar architecture to that of β-catenin. (wikipedia.org)
  • This suggests that a WNT-independent mechanism of beta-catenin activation via phospholipase C is involved in the EMT induced by Cyclin A2 depletion. (cnrs.fr)
  • Alterations in the localization and expression levels of β-catenin have been associated with various forms of heart disease, including dilated cardiomyopathy. (wikipedia.org)
  • δ-Catenin-null neurons have no alterations in global levels of active Rac1/RhoA. (jneurosci.org)
  • Knockdown of erbin results in alterations in localization of δ-catenin. (jneurosci.org)
  • In addition, δ-catenin, ARVCF, and p0071 also contain a PDZ binding motif at the C terminus. (jneurosci.org)
  • This article presents the roles of the Wnt/β-catenin pathway in cancer and current therapeutic strategies involving this pathway. (chemdiv.com)
  • Consistent with the different origins of dorsal and ventral dermal cells, our results demonstrate both conserved and divergent roles ofβ-catenin/Wnt signaling in dermal development. (biologists.com)
  • Activation of the Wnt pathway stabilizes beta-catenin, allowing it to move into the cell nucleus and control the expression of many different genes. (eurekalert.org)
  • Moreover, loss of beta-catenin in vascular SMCs decreased the expression of a set of pro-migration/invasion genes. (yu.edu)
  • In these vessels, beta-catenin function was dispensable to maintain their structure and state of SMC differentiation. (yu.edu)
  • HelixC is not necessary for β-catenin to function in cell-cell adhesion. (wikipedia.org)
  • A representative example of a 'druggable' 'hot spots' included specific topological features of the β -catenin interaction. (chemdiv.com)
  • Specifically, the beta-catenin C-terminal interaction domain was required and sufficient to provide the necessary signal for arteriogenesis, whereas the N-terminal interaction domain was dispensable. (yu.edu)
  • β-catenin-IN-2 can be used for the study of colorectal cancer. (dcchemicals.com)
  • Reciprocity between membranous and nuclear expression of beta-catenin in colorectal tumours. (ox.ac.uk)