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  • activity
  • All tocotrienol and tocopherol isomers have some physical antioxidant activity due to an ability to donate a hydrogen atom (a proton plus electron) from the hydroxyl group on the chromanol ring, to free radical and reactive oxygen species. (wikipedia.org)
  • topically
  • Topically applied DL-alpha-tocopherol was substantially absorbed in skin, but the 6-month application did not significantly reduce numbers of preexisting AKs on moderately to severely sun-damaged forearms. (nih.gov)
  • metabolism
  • Topical tocopherol did not normalize established sun-induced lesions, but DL-alpha-tocopherol-induced reductions in polyamine metabolism are consistent with the inhibition of skin squamous cell carcinogenesis as seen in previous human trials and animal models. (nih.gov)
  • oils
  • Natural sources with the highest amounts of alpha-tocopherol include wheat germ, nuts and seeds (particularly sunflower seeds and almonds), and vegetable oils, such as wheat germ and sunflower oils. (thefreedictionary.com)
  • Tocopherols are similar in chemical structure and are contained in large quantities in vegetable oils. (thefreedictionary.com)
  • The highest tocopherol content is found in the germs of cereals and in the oils extracted from them. (thefreedictionary.com)
  • α-Tocopherol is the main source found in supplements and in the European diet, where the main dietary sources are olive and sunflower oils, while γ-tocopherol is the most common form in the American diet due to a higher intake of soybean and corn oil. (wikipedia.org)
  • oxidative
  • Men with alpha-tocopherol levels below the median combined with high oxidative stress, i.e., 8-iso-PGF(2 alpha) above the median, had 7% (95% CI 3-11%) lower BMD at the lumbar spine and 5% (95% CI 2-9%) lower BMD at the proximal femur. (nih.gov)
  • Furthermore, diets supplemented with alpha-tocopherol have been shown to reduce the oxidative effects of salt and the development of thiobarbituric acid-reactive substances in chicken and pork (Hasty et al. (scielo.br)
  • increases
  • Stocker, "Cosupplementation with coenzyme Q prevents the prooxidant effect of alpha-tocopherol and increases the resistance of LDL to transition metal-dependent oxidation initiation," Arteriosclerosis, Thrombosis, and Vascular Biology, vol. (thefreedictionary.com)
  • levels
  • conversely, the significant reductions in polyamine levels resulting from the topical DL-alpha-tocopherol application are consistent with reductions in tumorigenesis potential. (nih.gov)
  • human
  • Chemoprevention of human actinic keratoses by topical DL-alpha-tocopherol. (nih.gov)
  • Contralateral arms of healthy human volunteers with actinic keratoses (AK) were randomly assigned to receive either 12.5% DL-alpha-tocopherol or placebo in a crème base for 6 months. (nih.gov)