• Zoxazolamine paralysis time was increased in Cu deficient rats. (cdc.gov)
  • PCN increased the level of testosterone 6β-hydroxylation and decreased the duration of the loss of righting-reflex time following zoxazolamine administration in wild-type mice, but did not effect either of these parameters in PXR-KO mice. (aspetjournals.org)
  • One of its active metabolites, chlorzoxazone, was found to show less toxicity, and was subsequently marketed in place of zoxazolamine. (wikipedia.org)
  • Using the patch clamp technique we investigated the effects of the centrally acting muscle relaxant chlorzoxazone and three structurally related compounds, 1-ethyl-2-benzimidazolinone (1-EBIO), zoxazolamine, and 1,3-dihydro-1-[2-hydroxy-5-(triflu oromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one (NS 1619) on recombinant rat brain SK2 channels (rSK2 channels) expressed in HEK293 mammalian cells. (nih.gov)
  • When applied externally, chlorzoxazone, 1-EBIO, and zoxazolamine activated rSK2 channel currents in cells dialyzed with a nominally Ca(2+)-free intracellular solution. (nih.gov)
  • Activation of rSK2 channels by chlorzoxazone, 1-EBIO, and zoxazolamine declined at higher drug concentrations. (nih.gov)
  • Zoxazolamine, when applied in combination with chlorzoxazone or 1-EBIO, partially inhibited the rSK2 channel current responses, suggesting a partial-agonist mode of action. (nih.gov)
  • Zoxazolamine acts centrally as a muscle relaxant, but the mechanism of its action is not understood. (nih.gov)
  • Zoxazolamine is a centrally acting myorelaxant, which is formerly used as an antispasmodic and uricosuric. (csnpharm.cn)
  • Hexobarbitone-induced sleeping time, zoxazolamine-induced paralysis time, bromosulphalein (BSP) retention, serum levels of transaminases, bilirubin and total protein were used as indices of liver injury. (epa.gov)
  • 2002). In addition Piperine has also been shown to enhance the bioavailability of drugs like vascicine, sparteine, curcumin, barbiturate and oxyphenylbutazone, zoxazolamine, propranalol and theophylline in animal experiments (Atal et al. (def-sa.com)