• genes
  • In the zebrafish, two of the three vertebrate hh genes are duplicated: SHH a, SHH b (formerly described as tiggywinkle hedgehog, named for Mrs. Tiggy-Winkle, a character from Beatrix Potter's books for children), ihha and ihhb (formerly described as echidna hedgehog, named for the spiny anteater and not for the echidna character Knuckles in the Sonic franchise). (wikipedia.org)
  • The following genes encode small Maf proteins MAFF (Human), Maff (Mouse), maft renamed maff (Zebrafish) MAFG (Human), Mafg (Mouse), mafg (Zebrafish) MAFK (Human), Mafk (Mouse), mafk (Zebrafish) sMaf proteins were identified as members of the Maf family transcription factors. (wikipedia.org)
  • embryos
  • Translational suppression or CRISPR/Cas9 genome editing of apol1 in zebrafish embryos results in podocyte loss and glomerular filtration defects. (nih.gov)
  • structurally
  • Because MafF, MafG and MafK are well-conserved 18 kDa proteins that lack a transcriptional activation domain, they are classified into the small Maf subfamily, which is structurally and functionally distinct from the large Maf subfamily. (wikipedia.org)
  • expression
  • Moreover, APOL1 G2, but not G1, expression alone promotes developmental kidney defects, suggesting a possible dominant-negative effect of the altered protein.Testing this interaction in vivo by co-suppressing both transcripts yielded no additive effects.Furthermore, concordant with the genetic interaction observed in SCD patients, APOL1 G2 reduces myh9 expression in vivo, suggesting a possible interaction between the altered APOL1 and myh9. (nih.gov)
  • Moreover, APOL1 G2, but not G1, expression alone promotes developmental kidney defects, suggesting a possible dominant-negative effect of the altered protein. (nih.gov)
  • NTR-mCherry zebrafish were flow-sorted and evaluated for apol1 RNA expression through RT-PCR. (nih.gov)
  • This discovery eventually led to the identification of the heat-shock proteins (HSP) or stress proteins whose expression this puffing represented. (wikipedia.org)
  • residues
  • Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. (uniprot.org)
  • tyrosine
  • The basic region of each Maf family protein contains a tyrosine residue, which is critical for the unique DNA-binding modes of these proteins (see below for details). (wikipedia.org)
  • In 2015, researchers discovered that PLEKHA7 recruits the so-called microprocessor complex (association of Drosha and DGCR8 proteins) to a growth-inhibiting site (apical zonula adherens) in epithelial cells instead of sites at basolateral areas of cell-cell contact containing tyrosine-phosphorylated p120 and active Src. (wikipedia.org)
  • synthesis
  • Increased synthesis of selected proteins in Drosophila cells following stresses such as heat shock was first reported in 1974. (wikipedia.org)
  • precursor
  • Goytain and Quamme identified a Mg2+ transporter encoded by an implantation-associated protein precursor, IAP, that is regulated by magnesium. (wikipedia.org)
  • family
  • Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. (wikipedia.org)
  • Some members of the HSP family are expressed at low to moderate levels in all organisms because of their essential role in protein maintenance. (wikipedia.org)
  • function
  • however, there is little functional evidence supporting the role of this protein in renal function. (nih.gov)
  • In vivo complementation studies of the G2 risk allele also indicate that the variant is deleterious to protein function. (nih.gov)
  • p>This subsection of the 'Function' section specifies the position and type of each DNA-binding domain present within the protein. (uniprot.org)
  • However, studies have revealed that most FXYD proteins have another specific function and act as tissue-specific regulatory subunits of the Na,K-ATPase. (wikipedia.org)
  • FXYD proteins appear to preferentially associate with Na,K-ATPase alpha1-beta isozymes, and affect their function in a way that render them operationally complementary or supplementary to coexisting isozymes. (wikipedia.org)
  • Many members of this group perform chaperone function by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress. (wikipedia.org)
  • Several heat shock proteins function as intra-cellular chaperones for other proteins. (wikipedia.org)
  • domain
  • binding domain present within the protein. (uniprot.org)
  • It was also independently discovered in Sandra Citi's group as a protein interacting with globular head domain of the Paracingulin in a yeast two-hybrid screen. (wikipedia.org)
  • The protein PDZD11 was identified as a protein interacting through its N-terminal region with the N-terminal WW domain of PLEKHA7, based on 2-hybrid screen and analysis of PLEKHA7 immunoprecipitates Unlike most other AJ proteins, but similar to afadin, PLEKHA7 is exclusively detected in the zonular apical part of AJ, but not in the "puncta adherentia" along lateral membranes of the epithelial cells. (wikipedia.org)
  • widely
  • For example, Hsp60, Hsp70 and Hsp90 (the most widely studied HSPs) refer to families of heat shock proteins on the order of 60, 70, and 90 kilodaltons in size, respectively. (wikipedia.org)
  • functions
  • Moreover, our interaction studies indicate that the MYH9 locus is also relevant to the phenotype in a stressed microenvironment and suggest that consideration of the context-dependent functions of both proteins will be required to develop therapeutic paradigms. (nih.gov)
  • transcription factors
  • sMaf proteins form homodimers by themselves and heterodimers with two other bZIP families of transcription factors, namely CNC (cap 'n' collar) proteins [p45 NF-E2 (NFE2), Nrf1 (NFE2L1), Nrf2 (NFE2L2), and Nrf3 (NFE2L3) Not to be confused with Nuclear Respiratory factors] and Bach proteins (Bach1 and Bach2). (wikipedia.org)
  • express
  • FACS podocytes also express zebrafish podocin (nphs2) but a purkinje-cell marker, wdr81, was undetectable. (nih.gov)
  • Bone morphogenetic protein 4 (BMP4) is released by the extra-embryonic ectoderm (ExE) at embryonic day 5.5 to 5.75 directly adjacent to the epiblast and causes the region of the epiblast nearest to the ExE to express Blimp1 and Prdm4 in a dose-dependent manner. (wikipedia.org)
  • functional
  • Each of these auxiliary subunits produces a distinct functional effect on the transport characteristics of the Na,K-ATPase that is adjusted to the specific functional demands of the tiss ue in which the FXYD protein is expressed. (wikipedia.org)
  • small
  • In 2016, researchers found that PLEKHA7 recruits the small PDZ protein PDZD11 to adherens junctions, thus resulting in the stabilisation of nectins at adherens junctions. (wikipedia.org)
  • region
  • The protein was discovered in Masatoshi Takeichi's lab while looking for potential binding partners for the N-terminal region of p120-catenin. (wikipedia.org)
  • cannot
  • be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein. (uniprot.org)
  • different
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)