• genes
  • Among the upregulated genes were intercellular adhesion molecule (ICAM)-1, macrophage inflammatory proteins, suppressors of cytokine signaling proteins (SOCS), IL-10 receptor, and galectin-7. (arvojournals.org)
  • Wnt and Notch are opposing components of a system which controls cellular fate within an organism and when the team looked at Notch they found that genes regulated by notch were up-regulated, Notch-stimulating proteins up-regulated and Notch-inhibiting proteins down-regulated. (eurekalert.org)
  • The WNT gene family consists of structurally related genes that encode secreted signaling proteins. (wikipedia.org)
  • Lastly, the absence of WNT4 also affects the expression of other genes that function in lung development such as Sox9 and FGF9. (wikipedia.org)
  • The β-elemene - a traditional Chinese medicine, upregulates MTA3's expression in breast cancer cells The MTA3-NuRD complex represses Snail, a master regulator of epithelial-to-mesenchymal transition (EMT), Wnt4 expression in mammary epithelial cells, and BCL6-corepressor target genes The MTA3-NuRD complex interacts with GATA3 to regulate the expression of GATA3 downstream targets. (wikipedia.org)
  • catenin
  • this study identifies a transcriptional switch involving the kinase Btk29A/ Btk and its phosphorylation target, beta-catenin , which functions downstream of Wnt4 in escort cells to terminate Drosophila germ cell proliferation through up-regulation of piwi expression. (antikoerper-online.de)
  • Catenin beta-1, also known as β-catenin, is a protein that in humans is encoded by the CTNNB1 gene. (wikipedia.org)
  • β-catenin is a dual function protein, involved in regulation and coordination of cell-cell adhesion and gene transcription. (wikipedia.org)
  • It is a member of the catenin protein family and homologous to γ-catenin, also known as plakoglobin. (wikipedia.org)
  • β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. (wikipedia.org)
  • Beta-catenin was initially discovered in the early 1990s as a component of a mammalian cell adhesion complex: a protein responsible for cytoplasmatic anchoring of cadherins. (wikipedia.org)
  • But very soon, it was realized that the Drosophila protein armadillo - implicated in mediating the morphogenic effects of Wingless/Wnt - is homologous to the mammalian β-catenin, not just in structure but also in function. (wikipedia.org)
  • Thus beta-catenin became one of the very first examples of moonlighting: a protein performing more than one radically different cellular function. (wikipedia.org)
  • gene expression
  • Recently, the analysis of the gene expression profile of FRTL-5 differentiated thyroid cells after the silencing of Pax8 identified Wnt4 as a novel target. (biomedcentral.com)
  • Here we demonstrate that Pax8 is involved in the transcriptional modulation of Wnt4 gene expression directly binding to its 5'-flanking region, and that Wnt4 expression in FRTL-5 cells is TSH-dependent. (biomedcentral.com)
  • MTA3 protein localizes in the nucleus as well as in other cellular compartments MTA3 is a component of the nucleosome remodeling and deacetylate (NuRD) complex and participates in gene expression. (wikipedia.org)
  • Molecular
  • Philibert P, Biason-Lauber A, Gueorguieva I, Stuckens C, Pienkowski C, Lebon-Labich B, Paris F, Sultan C. Molecular analysis of WNT4 gene in four adolescent girls with mullerian duct abnormality and hyperandrogenism (atypical Mayer-Rokitansky-Küster-Hauser syndrome). (nih.gov)
  • mammary
  • In this stage, mammary gland development depends on systemic (and maternal) hormones, but is also under the (local) regulation of paracrine communication between neighboring epithelial and mesenchymal cells by parathyroid hormone-related protein (PTHrP). (wikipedia.org)
  • secretion
  • inhibin and activins - secreted after puberty, and work together to regulate FSH secretion androgen binding protein (also called testosterone binding globulin) - increases testosterone concentration in the seminiferous tubules to stimulate spermatogenesis estradiol - aromatase from Sertoli cells convert testosterone to 17 beta estradiol to direct spermatogenesis glial cell line-derived neurotrophic factor (GDNF) - has been demonstrated to function in promoting undifferentiating spermatogonia, which ensures stem cell self-renewal during the perinatal period. (wikipedia.org)
  • receptor
  • The expression of Wnt4 is regulated by estrogen via an estrogen receptor alpha-dependent pathway in rat pituitary growth hormone-producing cells. (abcam.com)
  • ovaries
  • This protein is also involved in development of the ovaries, from before birth through adulthood, and is important for development and maintenance of egg cells (oocytes) in the ovaries. (nih.gov)
  • modulates
  • We have identified and characterized a functional Pax8 binding site in the 5'-flanking region of the Wnt4 gene and we show that Pax8 modulates the expression of Wnt4 in thyroid cells. (biomedcentral.com)
  • steroidogenic
  • SRY , encoding the sex-determining region Y protein, NR5A1 , encoding a transcription factor called steroidogenic factor 1, and DHH , encoding the desert hedgehog protein, were directly sequenced. (rbmb.net)
  • heterozygous
  • A heterozygous partial deletion was found in NR5A1 and heterozygous partial duplications were found in WNT4 . (rbmb.net)
  • Wnts
  • Wnts are glycosylated proteins that usually act locally on neighboring cells or on the Wnt-secreting cells themselves. (frontiersin.org)
  • MMTV
  • Auf www.antikoerper-online.de finden Sie aktuell 118 Wingless-Type MMTV Integration Site Family, Member 4 (WNT4) Antikörper von 25 unterschiedlichen Herstellern. (antikoerper-online.de)
  • cDNA
  • The researchers expressed the complementary DNA (cDNA) of the murine MyoD protein in a different cell lines (fibroblast and adipoblast) and found MyoD converted them to myogenic cells. (wikipedia.org)
  • reproductive
  • The WNT4 gene provides instructions for producing a protein that is important for the formation of the female reproductive system , the kidneys, and several hormone-producing glands. (nih.gov)
  • Other members of the WNT family that are required for the development of the reproductive tract are Wnt4 and Wnt7a. (wikipedia.org)
  • cells
  • Thymoma cells were cultured and transfected with shRNA plasmids targeting the Wnt4 gene. (spandidos-publications.com)
  • The fight against infections prompts creation of memory T cells that then "remember" antigens or proteins found on cells infected with viruses or bacteria. (medindia.net)
  • This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. (wikipedia.org)
  • Development of Sertoli cells is directed by the testis-determining factor protein. (wikipedia.org)
  • transferrin - a blood plasma protein for iron ion delivery The occluding junctions of Sertoli cells form the blood-testis barrier, a structure that partitions the interstitial blood compartment of the testis from the adluminal compartment of the seminiferous tubules. (wikipedia.org)
  • This repair likely employs the process of non-homologous end joining involving XRCC1 and PARP1 proteins that are expressed in Sertoli cells. (wikipedia.org)
  • development
  • Wnt4 action in gonadal development and sex determination. (nih.gov)
  • Biason-Lauber A, Konrad D. WNT4 and sex development. (nih.gov)
  • Overall, the present concluded that Wnt4 has an important role in thymoma development, which appears to be activated through a JNK mediated planar cell polarity‑like pathway. (spandidos-publications.com)
  • It is caused by loss of function in WNT4, a protein involved in sex development. (wikipedia.org)
  • When WNT4 is knocked out, there are many problems that occur in lung development. (wikipedia.org)
  • It has been shown that when WNT4 is knocked out, the lung buds formed are reduced in size and proliferation has greatly diminished which cause underdeveloped or incomplete development of the lungs. (wikipedia.org)
  • In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. (wikipedia.org)
  • However, the role of Wnt proteins in the process and development of inflammation in atherosclerosis and other inflammatory conditions is not yet clear. (wikipedia.org)
  • family
  • WNT2 (Wnt Family Member 2) is a Protein Coding gene. (genecards.org)
  • The overall organization of MTA3 protein domains is similar to the other two family members with a BAH (Bromo-Adjacent Homology), a ELM2 (egl-27 and MTA1 homology), a SANT (SWI, ADA2, N-CoR, TFIIIB-B), a GATA-like zinc finger, and one predicted bipartite nuclear localization signal (NLS). (wikipedia.org)
  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. (wikipedia.org)