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  • knockdown
  • Specific silencing RNA knockdown of Wnt4, but not Wnt2, significantly reduced VSMC proliferation. (icr.ac.uk)
  • Recombinant Wnt4, but not Wnt2, significantly increased VSMC proliferation by approximate to 2-fold and silencing RNA knockdown revealed this is via Frizzled 1. (icr.ac.uk)
  • mice
  • Importantly, we also showed that intimal thickening and VSMC proliferation after carotid artery ligation was significantly retarded in Wnt(4/-) compared to Wnt4(+/+) mice. (icr.ac.uk)
  • mammary
  • In this stage, mammary gland development depends on systemic (and maternal) hormones, but is also under the (local) regulation of paracrine communication between neighboring epithelial and mesenchymal cells by parathyroid hormone-related protein (PTHrP). (wikipedia.org)
  • secretion
  • inhibin and activins - secreted after puberty, and work together to regulate FSH secretion androgen binding protein (also called testosterone binding globulin) - increases testosterone concentration in the seminiferous tubules to stimulate spermatogenesis estradiol - aromatase from Sertoli cells convert testosterone to 17 beta estradiol to direct spermatogenesis glial cell line-derived neurotrophic factor (GDNF) - has been demonstrated to function in promoting undifferentiating spermatogonia, which ensures stem cell self-renewal during the perinatal period. (wikipedia.org)
  • ovaries
  • This protein is also involved in development of the ovaries, from before birth through adulthood, and is important for development and maintenance of egg cells (oocytes) in the ovaries. (nih.gov)
  • steroidogenic
  • SRY , encoding the sex-determining region Y protein, NR5A1 , encoding a transcription factor called steroidogenic factor 1, and DHH , encoding the desert hedgehog protein, were directly sequenced. (rbmb.net)
  • amino
  • Of these, nine MTA3 transcripts are predicted to code six proteins of 392, 514, 515, 537, 590 and 594 amino acids long, two MTA3 transcripts code 18 amino acids and 91 amino acids polypeptides. (wikipedia.org)
  • The murine Mta3 gene contains nine transcripts, six of which are predicted to code proteins ranging from 251 amino acids to 591 amino acids while one transcript codes for 40 amino acids polypeptide. (wikipedia.org)
  • It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. (wikipedia.org)
  • It encodes a protein showing 98%, 98%, and 87% amino acid identity to the mouse, rat and the xenopus Wnt5a protein, respectively. (wikipedia.org)
  • Wnt1
  • Here they show that two other proteins, Wnt1 and Wnt5a are produced at high concentrations at the top of the cord and at consecutively lower levels farther down. (rxpgnews.com)
  • The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. (wikipedia.org)
  • UniProt
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • heterozygous
  • A heterozygous partial deletion was found in NR5A1 and heterozygous partial duplications were found in WNT4 . (rbmb.net)
  • phosphorylation
  • While not completely understood, MyoD is now thought to function as a major myogenesis controller in an on/off switch association mediated by KAP1 (KRAB [Krüppel-like associated box]-associated protein 1) phosphorylation. (wikipedia.org)
  • Wnts
  • Wnts are glycosylated proteins that usually act locally on neighboring cells or on the Wnt-secreting cells themselves. (frontiersin.org)
  • Wingless
  • But very soon, it was realized that the Drosophila protein armadillo - implicated in mediating the morphogenic effects of Wingless/Wnt - is homologous to the mammalian β-catenin, not just in structure but also in function. (wikipedia.org)
  • cDNA
  • The researchers expressed the complementary DNA (cDNA) of the murine MyoD protein in a different cell lines (fibroblast and adipoblast) and found MyoD converted them to myogenic cells. (wikipedia.org)
  • catenin
  • Conclusions: This study demonstrates that Wnt/beta-catenin signaling occurs in proliferating VSMCs during intimal thickening and indicates that this is a result of Wnt4 upregulation. (icr.ac.uk)
  • It is a member of the catenin protein family and homologous to γ-catenin, also known as plakoglobin. (wikipedia.org)
  • β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. (wikipedia.org)
  • Beta-catenin was initially discovered in the early 1990s as a component of a mammalian cell adhesion complex: a protein responsible for cytoplasmatic anchoring of cadherins. (wikipedia.org)
  • Thus beta-catenin became one of the very first examples of moonlighting: a protein performing more than one radically different cellular function. (wikipedia.org)
  • reproductive
  • The WNT4 gene provides instructions for producing a protein that is important for the formation of the female reproductive system , the kidneys, and several hormone-producing glands. (nih.gov)
  • Other members of the WNT family that are required for the development of the reproductive tract are Wnt4 and Wnt7a. (wikipedia.org)
  • Researchers
  • Canadian and Finnish researchers have identified a protein called Wnt4, which can stimulate the production of T-cells, the white blood cells that recognise and kill infectious agents. (medindia.net)
  • In 2003, University of Chicago researchers reported that a gradient of biochemical signals known as the Wnt proteins acted as a guide for sensory nerves. (rxpgnews.com)
  • family
  • Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. (cancerindex.org)
  • The overall organization of MTA3 protein domains is similar to the other two family members with a BAH (Bromo-Adjacent Homology), a ELM2 (egl-27 and MTA1 homology), a SANT (SWI, ADA2, N-CoR, TFIIIB-B), a GATA-like zinc finger, and one predicted bipartite nuclear localization signal (NLS). (wikipedia.org)
  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. (wikipedia.org)
  • homologous
  • This repair likely employs the process of non-homologous end joining involving XRCC1 and PARP1 proteins that are expressed in Sertoli cells. (wikipedia.org)
  • development
  • Wnt4 action in gonadal development and sex determination. (nih.gov)
  • Biason-Lauber A, Konrad D. WNT4 and sex development. (nih.gov)
  • It is caused by loss of function in WNT4, a protein involved in sex development. (wikipedia.org)
  • When WNT4 is knocked out, there are many problems that occur in lung development. (wikipedia.org)
  • It has been shown that when WNT4 is knocked out, the lung buds formed are reduced in size and proliferation has greatly diminished which cause underdeveloped or incomplete development of the lungs. (wikipedia.org)
  • In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. (wikipedia.org)
  • Development of Sertoli cells is directed by the testis-determining factor protein. (wikipedia.org)