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  • antithrombin
  • Apixaban was added to plasma from healthy subjects in the concentration range 0-1000 μg L(-1) , and analyses were performed with different reagents for activated partial thromboplastin time (APTT), prothrombin time (PT), antithrombin, protein C, and protein S. A lupus anticoagulant assay and an APTT assay with varying phospholipid concentrations were used to study the phospholipid dependence. (diva-portal.org)
  • effects
  • The purpose of this study was to examine the effects of early and delayed processing on TEG ® parameters using kaolin-activated citrated blood samples in the intensive care population. (wiley.com)
  • Laboratory monitoring is not necessary, but the effects on common coagulation reagents and assays constitute clinically valuable information. (diva-portal.org)
  • To investigate the effects of apixaban on commonly used coagulation methods, and to evaluate anti-FXa assays for specific determination of the drug concentration. (diva-portal.org)
  • 1948
  • He continued on the faculty of Harvard until 1956, although he had resigned his position as Chief of the Cardiac Service at the Massachusetts General Hospital in 1948 to devote time to the development of the National Heart Institute, following adoption of the National Heart Act, which was signed into law by President Truman in 1948. (wikipedia.org)
  • In 1948, as part of a research team at the Instituto Biológico, Dr. Rosenfeld co-discovered, with two other Brazilian physiologists and pharmacologists, Drs. Maurício Rocha e Silva and Wilson Teixeira Beraldo, a new endogenous peptide capable of causing a powerful fall of blood pressure on animal preparations, which they called bradykinin. (wikipedia.org)
  • Assay
  • The assay methods and apparatus are particularly useful for preforming enzyme assays where signal developed as a function of time is critical. (google.es)
  • 4. An assay as in claim 3, wherein the patient sample is blood. (google.es)
  • 7. An assay as in claim 1, wherein the analyte is a component of the coagulation pathway and the substrate produces the detectable signal upon activation by said component. (google.es)
  • 10. An assay as in claim 1, wherein the production of signal is detected at a plurality of time points over a preselected time duration. (google.es)
  • electrode
  • A modular multi-channel automated medical analyzer device is disclosed, characterized by use of an ion selective electrode and/or enzymatic electrode/wash cell system which permits rapid analysis of various substances of interest contained within undiluted body fluids such as whole blood, serum and/or plasma. (google.com)
  • cuvette
  • The blood is then supplied to a disposable cuvette placed within the testing device. (google.ca)
  • The blood is drawn into multiple conduits within the cuvette. (google.ca)
  • 10. The cuvette according to claim 1, further comprising a reservoir, selectively coupled to said channel for receiving a blood sample containing an anticoagulant from a patient, wherein said channel enables the sample to flow from said reservoir to said plurality of conduits. (google.ca)
  • 11. The cuvette according to claim 10, wherein said reservoir is biased into a first position not in contact with said channel, whereby pressure from applying the blood sample to the reservoir moves the reservoir to a second position in contact with the channel, thereby enabling the sample to flow from the reservoir into the channel. (google.ca)
  • Blood (300 µl, anticoagulated with citrate) is placed into the disposable cuvette using an electronic pipette. (wikipedia.org)
  • reaction
  • The device allows a timed reaction to take place without application of external forces such as vibration, rocking, optical activation, heat or pulsing. (google.com)
  • Four values that represent clot formation are determined by this test: the reaction time (R value), the K value, the angle and the maximum amplitude (MA). (wikipedia.org)
  • anticoagulant
  • an anticoagulant contained within a second one of said conduits, wherein said anticoagulant reacts with the blood sample delivered to said second one of said conduits to produce a blood control sample having abnormal clotting characteristics. (google.ca)
  • Both are used to determine the clotting rate of blood which can be affected by anticoagulant usage, liver damage and Vitamin K levels. (wikipedia.org)
  • Blood is drawn into a test tube containing oxalate or citrate, molecules which act as an anticoagulant by binding the calcium in a sample. (wikipedia.org)
  • Grapefruit interferes with some anticoagulant drugs, increasing the amount of time it takes for them to be metabolized out of the body, and so should be eaten only with caution when on anticoagulant drugs. (wikipedia.org)
  • Among his many other contributions to biomedical sciences are the development of a rapid staining for blood smears combining May-Grunwald and Giemsa techniques in 1947 (Rosenfeld staining), the introduction a new treatment for chronic leukemia using personal control of maintenance dosis (1955) and described hementerin, an anticoagulant isolated of a Brazilian species of leech (Haementeria depressa) jointly with Eva Maria Antonia Kelen in 1975. (wikipedia.org)
  • test
  • The test is started b produced by the photocell w jected into the cuvett digital time circuit and display ferentiation circuit and a det Indianapolis, Ind. (google.com)
  • The normalized blood is tested simultaneously with the untreated blood to provide a reference value against which the functionality of the test system and the quality of the sample can be judged. (google.ca)
  • A historical name for this measure is the kaolin-cephalin clotting time (KCCT), reflecting kaolin and cephalin as materials historically used in the test. (wikipedia.org)
  • Some anticoagulants are used in medical equipment, such as test tubes, serum-separating tubes, blood transfusion bags, and dialysis equipment. (wikipedia.org)
  • The decision to begin therapeutic anticoagulation often involves the use of multiple bleeding risk predictable outcome tools as non-invasive pre-test stratifications due to the potential for bleeds while on blood thinning agents. (wikipedia.org)
  • Transfusion
  • Xenotransfusion uses non-human animals to aid in the shortage of blood for blood transfusion in humans. (wikipedia.org)
  • Although there needs to be more study on the topic some scientists are already considering the idea to use Sus scrofa domesticus (pigs) for blood transfusion. (wikipedia.org)
  • Transfusion of canine blood into domestic cats was performed historically and continues to be performed in some countries. (wikipedia.org)
  • assessment
  • A mathematical formula determined by the manufacturer can be used to determine a Coagulation Index (CI) (or overall assessment of coagulability) which takes into account the relative contribution of each of these 4 values into 1 equation.The G-value is a log-derivation of the MA and is meant to also represent the clot strength using dynes/sec as its units. (wikipedia.org)
  • measure
  • INR self-monitoring is used by patients on long-term and on lifetime anti-coagulation therapy to measure their INR (International Normalized Ratio) levels themselves, rather than at a clinic. (wikipedia.org)
  • thrombin
  • Hematology reagents used to determine the time required for thrombin to convert fibrinogen to an insoluble fibrin clot when fibrin formation is triggered by the addition of ecarin (a snake venom) to the specimen. (medicalproductguide.com)
  • thrombus
  • Unlike thromboxane synthase inhibitors such as ozagrel, seratrodast does not affect thrombus formation, time to occlusion and bleeding time. (wikipedia.org)
  • medical
  • The outcomes of patients with severe stroke depend largely on medical strategies on acute stage, especially on blood pressure (BP) management. (clinicaltrials.gov)
  • As such, Dr. Rosenfeld was concerned about the lack of medical knowledge about the actions of venoms on the human body and its medical therapy, at the time. (wikipedia.org)
  • Richardson was a founder, and for thirty-five times in succession the President of the St Andrews Medical Graduates' Association. (wikipedia.org)
  • Treatment
  • 72h) severe stroke (GCS ≦ 12 or NIHSS ≧ 11) and elevated BP (systolic blood pressure ≧150 mmHg or diastolic blood pressure ≧ 100 mmHg) will be randomly assigned to individualized anti-hypertension treatment or guideline-based treatment for 7 days. (clinicaltrials.gov)
  • optimum
  • Both gold and carbon parallel electrodes were tested and the optimum operating frequency for most sensitive coagulation detection was investigated. (asme.org)
  • The purpose of this academic lead study is to explore ideal blood pressure targets and optimum individualized anti-hypertension strategies in acute severe stroke. (clinicaltrials.gov)
  • determine
  • Many of these methods do not determine whether there is an adequate blood sample, and thus are subject to errors that can enter into processes which do not determine adequacy of the blood sample. (google.es)
  • occur
  • Type II domains occur two times in fibronectin. (wikipedia.org)
  • Some of them occur naturally in blood-eating animals such as leeches and mosquitoes, where they help keep the bite area unclotted long enough for the animal to obtain some blood. (wikipedia.org)
  • therapy
  • People on anti-coagulation therapy who are self-testing provide the INR reading they obtain from their monitor to their healthcare professionals at an agreed time, generally by telephone. (wikipedia.org)
  • Extract from a study into the impact of self-monitoring on the quality of life of patients under anti-coagulation therapy. (wikipedia.org)
  • Self-monitoring can improve the quality of oral anti-coagulation therapy, with patients more frequently in the therapeutic range, while improving benefits and decreasing harm. (wikipedia.org)
  • From the conclusions of a review of studies of self-monitoring in oral anti-coagulation therapy. (wikipedia.org)
  • system
  • The signal of the pin suspended in the blood sample is transmitted via an optical detector system. (wikipedia.org)
  • XTF has not been tested in humans, however current evidence shows that pRBCs will function normally in humans due to a relation between porcine blood groups and human ABO group system. (wikipedia.org)
  • Global methods play the key role at the first stage of diagnostics: they provide an integral picture of alterations within the coagulation system and allow predicting a tendency to hyper- or hypo-coagulation in general. (wikipedia.org)
  • represents
  • The R value represents the time until the first evidence of a clot is detected. (wikipedia.org)
  • The K value is the time from the end of R until the clot reaches 20mm and this represents the speed of clot formation. (wikipedia.org)
  • However, it represents a great opportunity for new science as well as an unlimited blood bank for blood transfusions. (wikipedia.org)
  • different
  • The patterns of changes in strength and elasticity in the clot provide information about how well the blood can perform hemostasis, and how well or poorly different factors are contributing to clot formation. (wikipedia.org)
  • flow
  • Not only do they have the potential to seriously reduce collections and undermine cash flow, they also are time consuming and costly to resolve. (medicalproductguide.com)
  • procedure
  • This procedure can be performed without affecting the health of the donor, as only about 10% of their blood volume is used each time. (wikipedia.org)
  • Carotid artery blood from the lamb was introduced to a vein in the patient's inner elbow, and the procedure ultimately resulted in a successful recovery. (wikipedia.org)
  • The procedure time does not exceed 10 minutes. (wikipedia.org)
  • Analysis
  • Analysis is accomplished by introducing cells in suspension to the center of a focused liquid stream and causing them to pass, one at a time, through a focused light from a high power lamp or laser. (google.com)
  • study
  • Rosenfeld was interested in the study of biochemistry of the action of snake venom toxins in animals and humans, particularly those of the Bothrops family (lancehead or jararaca), which is extremely abundant all over Brazil and which caused a great number of accidents and deaths at his time. (wikipedia.org)
  • bile
  • See "Interaction" section under Bile acid sequestrant Coagulation/Bleeding Exercise caution in concomitant treatment with oral coumarin anticoagulants (e.g. warfarin). (wikipedia.org)
  • vessels
  • t-PA is released into the blood very slowly by the damaged endothelium of the blood vessels, such that, after several days (when the bleeding has stopped), the clot is broken down. (wikipedia.org)
  • This, however, requires puncture of the femoral artery with a sheath and advancing a thin tube through the blood vessels to the brain where radiocontrast is injected before X-ray images are obtained. (wikipedia.org)
  • Lack of blood vessels and inability of the epidermis to retain moisture, presence of sebaceous glands in the dermis provides an environment unsuitable for the survival of microbes. (wikipedia.org)
  • Meningococcemia, like many other gram-negative blood infections, can cause disseminated intravascular coagulation (DIC), which is the inappropriate clotting of blood within the vessels. (wikipedia.org)
  • This is due to the release of toxins into the blood that break down the walls of blood vessels. (wikipedia.org)
  • In this case, bacterial toxins rupture blood vessels and can rapidly shut down vital organs. (wikipedia.org)
  • thus
  • The loss of the atrial kick due to atrial fibrillation ( i.e. blood cannot flow into the left ventricle thus accumulating in the left atrium ) can cause a precipitous decrease in cardiac output and sudden congestive heart failure. (wikipedia.org)
  • Annexin A5 forms a shield around negatively charged phospholipid molecules, thus reducing their availability for coagulation. (wikipedia.org)
  • It absorbed the water in the blood, thus increasing its already present clotting capabilities, while also activating platelets. (wikipedia.org)
  • typically
  • The condition is typically seen in premature infants, and the timing of its onset is generally inversely proportional to the gestational age of the baby at birth (i.e. the earlier a baby is born, the later signs of NEC are typically seen). (wikipedia.org)
  • recurrent
  • These are mostly seizures affecting only one part of the body and unilateral (occurring on one side), but occasionally the seizures are generalised and rarely they lead to status epilepticus (persistent or recurrent seizure activity for a long period of time). (wikipedia.org)
  • pressures
  • A normal mitral valve will not impede the flow of blood from the left atrium to the left ventricle during (ventricular) diastole, and the pressures in the left atrium and the left ventricle during ventricular diastole will be equal. (wikipedia.org)
  • citation needed] When the mitral valve area goes less than 1 cm2, there will be an increase in the left atrial pressures (required to push blood through the stenotic valve). (wikipedia.org)
  • liver
  • It opens and cleanses the liver, helps the jaundice, and is very beneficial to the bowels, healing all inward wounds, bruises, hurts and other distempers…The liver is the former of the blood, and blood the nourisher of the body, and Agrimony a strengthener of the liver. (yorkshireherbalist.co.uk)
  • important
  • PAR-1 has multifaceted effects and plays a key role in mediating the interplay between coagulation and inflammation, which is important in the pathogenesis of inflammatory and fibrotic lung diseases. (wikipedia.org)
  • increases
  • A bespoke combination of an ultrasound dissector with a high-frequency surgical instrument is the intelligent solution for considerable cost and time savings, as it considerably increases the scope of application possibilities in the operating theatre. (swordmedical.ie)
  • The latter leads to increase risk of atrial fibrillation, which increases the risk of blood stasis (motionless). (wikipedia.org)
  • This increases the risk of coagulation. (wikipedia.org)
  • As the gradient across the mitral valve increases, the amount of time necessary to fill the left ventricle with blood increases. (wikipedia.org)
  • product
  • The original formulation of the first generation product contained the active ingredient zeolite, which promoted blood clotting. (wikipedia.org)
  • involves
  • The test involves injection into a vein (usually in the arm) of a radioopaque substance, and time is allowed for the bloodstream to carry it to the cerebral veins - at which point the scan is performed. (wikipedia.org)
  • cause
  • Though the exact mechanism is not known, cocaine and tobacco cause systemic vasoconstriction, which can severely restrict the placental blood supply (hypoperfusion and ischemia), or otherwise disrupt the vasculature of the placenta, causing tissue necrosis, bleeding, and therefore abruption. (wikipedia.org)
  • The Zeolite reaction with blood was exothermic, releasing heat during the clotting process, which could cause second degree burns. (wikipedia.org)
  • DIC can cause ischemic tissue damage when upstream thrombi obstruct blood flow and haemorrhage because clotting factors are exhausted. (wikipedia.org)
  • heart
  • This results in decreased ve- nous return of blood to the heart and subsequent decreased ven- tricular filling. (luxbar-starway.ru)
  • The principal features include congenital heart defect (typicall pulmonary valve stenosis with dysplastic pulmonary valve also atrial septal defect and hypertrophic cardiomyopathy), short stature, learning problems, pectus excavatum, impaired blood clotting, and a characteristic configuration of facial features including a webbed neck and a flat nose bridge. (wikipedia.org)
  • skin
  • A rash can develop under the skin due to blood leakage that may leave red or brownish pinprick spots, which can develop into purple bruising. (wikipedia.org)
  • result
  • The result is that the left ventricle gets filled with blood during early ventricular diastole, with only a small portion of extra blood contributed by contraction of the left atrium (the "atrial kick") during late ventricular diastole. (wikipedia.org)
  • especially
  • In general medical journals, however, it is best to specify the time intervals, especially as the Apgar score may be assessed at other intervals, eg, 10, 15, or 20 minutes. (amamanualofstyle.com)
  • supply
  • Much of the donor blood supply is obtained at "remote" blood donation events, such as blood drives at colleges, community events, etc., rather than at dedicated donation centers. (wikipedia.org)
  • poor
  • She developed insomnia, reduced appetite, poor concentration, irritability, disorganized what time should you take spironolactone, persecutory what time should you take spironolactone, and auditory hallucinations. (luxbar-starway.ru)
  • early
  • Randomized clinical trial on short-time compression with kaolin-filled pad: a new strategy to avoid early bleeding and subacute radial artery occlusion after percutaneous coronary intervention. (wikipedia.org)
  • former
  • As time passed and more and more anticonvulsants came on the market, primidone was pushed further and further away from its former place of prominence, and major Western pharmaceutical corporations became less and less interested in manufacturing and selling it. (wikipedia.org)
  • removal
  • In 2008, QuikClot Combat Gauze with kaolin was chosen by the CoTCCC( (Committee on Tactical Combat Casualty Care) as the only hemostatic dressing to be used by all branches of the US military for compressible hemorrhage not amenable to tourniquet use or as an adjunct to tourniquet removal if evacuation time is anticipated to be longer than 2 hours. (wikipedia.org)