• renal
  • A new novel missense mutation in VHL genes c.194 C>T, c.239 G>A, c.278 G>A, c.319 C>G, c.337 C>G leading to the following variations p.Ala 65 Val, p.Gly 80 Asp, p.Gly 93 Glu, p.Gln 107 Glu, p.Gln 113 Glu in the protein contributed to renal clear cell carcinoma. (wikipedia.org)
  • pVHL
  • Using green fluorescent protein-tagged end-binding protein 1 to label microtubule plus ends, we found that pVHL does not affect the microtubule growth rate but is needed to orient the growth of microtubules toward the cell periphery, a prerequisite for the formation of cilia. (rupress.org)
  • Moreover, pVHL interacts with the Par3-Par6-atypical PKC (aPKC) polarity complex, suggesting that pVHL may connect Par3-Par6-aPKC polarity proteins to microtubule capture and ciliogenesis. (rupress.org)
  • The VHL protein (pVHL) is involved in the regulation of a protein known as hypoxia inducible factor 1α (HIF1α). (wikipedia.org)
  • In normal physiological conditions, pVHL recognizes and binds to HIF1α only when oxygen is present due to the post translational hydroxylation of 2 proline residues within the HIF1α protein. (wikipedia.org)