• Infection
  • To successfully establish an infection, E. amylovora uses a complex regulatory network to sense the relevant environmental signals and coordinate the expression of early and late stage virulence factors involving two component signal transduction systems, bis-(3′-5′)-cyclic di-GMP (c-di-GMP) and quorum sensing. (mdpi.com)
  • These findings indicate that NS1 functions early during infection, strongly contributing to virulence. (rupress.org)
  • The expression of these virulence factors depends on the environmental conditions at the time of infection (see "environment section). (wikipedia.org)
  • isolates
  • This study aimed to determine the prevalence and characteristics of E. faecalis biofilm formation in a sample of clinical isolates and to explore the virulence factors associated with biofilm formation in those isolates. (frontiersin.org)
  • Biofilm formation was more frequently detected in enterococcal surface protein ( esp+ ), surface aggregating protein ( asa1 +), cytolysin A ( cylA +), or aggregation substance ( agg +) positive isolates than in isolates that were negative (-) for these virulence factors. (frontiersin.org)
  • infections
  • We could give anti-virulence antibiotics to people with healthy immune systems, who would be able to clear infections with this assistance," he said, "and traditional antibiotics combined with antivirulence therapies to people with compromised immune systems, who really need them. (eurekalert.org)
  • Salmonella
  • Fis was originally identified as the factor for inversion stimulation of the homologous Hin and Gin site-specific DNA recombinases of Salmonella and phage Mu, respectively. (wikipedia.org)
  • various
  • This phenotype mimics an effect produced by hepatocyte growth factor which may participate in various aspects of cancer, including metastasis. (wikipedia.org)
  • type III se
  • Many virulence determinants of E. amylovora have been characterized, including the Type III secretion system (T3SS), the exopolysaccharide (EPS) amylovoran, biofilm formation, and motility. (mdpi.com)
  • block
  • Now that the complex biochemistry of this virulence factor is better understood, they plan to start looking for agents that block its synthesis or activity. (eurekalert.org)
  • regulatory
  • combined A repressive effect of Fis and previously characterized negative regulatory factors could be responsible to keep the gene silenced most of the time. (wikipedia.org)
  • Important
  • Two important factors are the quorum sensing signal N -(3-oxododecanoyl)-L -homoserine lactone (3OC12) and the redox-active pyocyanin (PCN). (hindawi.com)
  • present
  • A PEST-like sequence is present in LLO and is considered essential for virulence, since mutants lacking the sequence lysed the host cell. (wikipedia.org)