• phage
  • After the head maturation, the tail is joined in one of two ways: Either the tail is constructed separately, and joined with the connector, or the tail is constructed directly onto the phage head. (wikipedia.org)
  • Group: dsDNA Order: Caudovirales Family: Myoviridae Sub-Family: Tevenvirinae Genus: T4virus (alias T4-like viruses) Escherichia virus AR1 Escherichia virus C40 Escherichia virus E112 Escherichia virus EMCL134 Escherichia virus RB3 Escherichia phage RB14 Enterobacteria phage T2 Enterobacteria phage T4 Shigella virus Pss1 Shigella virus Shfl2 Yersinia virus D1 Yersinia virus PST T4viruse species are nonenveloped, with a head and tail. (wikipedia.org)
  • Influenza virus has two kinds of peplomers: 1) triangular, spike-shaped "haemagglutinin" and 2) mushroom-shaped "neuraminidase" Virus Glycoprotein Receptor (biochemistry) T4 phage Viral entry Viral life cycle Saunders Comprehensive Veterinary Dictionary (3rd ed. (wikipedia.org)
  • Group: dsDNA Order: Caudovirales Family: Myoviridae Sub-Family: Peduovirinae Genus: P2likevirus Burkholderia phage phi52237 Burkholderia phage phiE202 Burkholderia phage phiE12-2 Enterobacteria phage 186 Enterobacteria phage P2 Enterobacteria phage PsP3 Enterobacteria phage Wphi Mannheimia phage phiMhaA1-PHL101 Pseudomonas phage phiCTX Ralstonia phage RSA1 Salmonella Fels-2 Salmonella SopEphi Yersinia phage L-413C P2likeviruses are nonenveloped, with a head and tail. (wikipedia.org)
  • Group: dsDNA Order: Caudovirales Family: Siphoviridae Genus: Tunalikevirus Cronobacter phage Esp2949-1 Enterobacter phage F20 Enterobacteria phage T1 Escherichia phage Eb49 Escherichia phage Jk06 Escherichia phage Rogue1 Escherichia phage Rtp Escherichia phage Tls Shigella phage Shfl1 Tunalikeviruses are nonenveloped, with a head and tail. (wikipedia.org)
  • Group: dsDNA Order: Caudovirales Family: Siphoviridae Genus: Lambdalikevirus Enterobacteria phage HK022 Enterobacteria phage HK97 Enterobacteria phage lambda Lambdalikeviruses are nonenveloped, with a head and tail. (wikipedia.org)
  • The virus has complex structural symmetry, with a capsid of the phage that is icosahedral with an inner diameter of 55 nm and a tail 19 nm in diameter and 28.5 nm long attached to the capsid. (wikipedia.org)
  • The phage also injects proteins needed to begin replication of the viral genome and cleave the host genome. (wikipedia.org)
  • Once the T7 phage has inserted the viral genome the process of DNA replication of the host genome is halted and replication of viral genome begins. (wikipedia.org)
  • Group: dsDNA Order: Caudovirales Family: Podoviridae Sub-Family: Picovirinae Genus: Phi29likevirus Bacillus phage B103 Bacillus phage GA-1 Bacillus phage phi29 Kurthia phage 6 Phi29likeviruses are nonenveloped, with a head and tail. (wikipedia.org)
  • The tail sheath contracts and the DNA of the phage is injected into the host cell. (wikipedia.org)
  • Group: dsDNA Order: Caudovirales Family: Podoviridae Sub-Family: Autographivirinae Genus: Sp6likevirus Enterobacteria phage K5 Enterobacteria phage K1-5 Enterobacteria phage K1E Enterobacteria phage SP6 Erwinia amylovora phage Era103 Sp6likeviruses are non-enveloped, with a head and tail. (wikipedia.org)
  • Group: dsDNA Order: Caudovirales Family: Myoviridae Genus: Phihlikevirus Halobacterium phage phiH Phihlikeviruses are nonenveloped, with a head and tail. (wikipedia.org)
  • membrane
  • Most of these proteins contain a C-terminal putative transmembrane (TM) fragment and a pair of hydrophobic alpha helices (alpha5-alpha6) similar to the membrane insertion fragments of the ion-channel domain of diphtheria toxin and colicins. (jove.com)
  • Moreover, we revealed mechanistic details of human peroxisomal membrane protein (PMP) entry into and exit from the ER membrane. (surrey.ac.uk)
  • In one project, we specifically focus on HIV-1 lipid-protein interactions at the plasma membrane, which are essential to form the specific lipid envelope of infectious HIV-1 particles and to stably recruit virion components to the assembly site. (g-f-v.org)
  • The tail section of the virus punches a hole through the bacterial cell wall and plasma membrane and the genome passes down the tail into the cell. (wikipedia.org)
  • sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
  • p>This subsection of the 'Names and taxonomy' section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. (uniprot.org)
  • The prediction of protein function from structure or sequence data remains a problem best addressed by leveraging information available from previously determined structure-function relationships. (ucsf.edu)
  • transmembrane
  • 11 . The isolated nucleic acid of any one of claims 3 - 10 , wherein the transmembrane protein is gp41 or a modified form of gp41, wherein the modification alters the immunogenicity of the molecule relative to wildtype gp41. (google.com)
  • 12 . The isolated nucleic acid of claim 11 , wherein the transmembrane protein is the gp41 ectodomain. (google.com)
  • 13 . The isolated nucleic acid of claim 11 or 12 , wherein the transmembrane protein is modified by the absence or presence of one or more canonical glycosylation sites absent or present in the wild type gp120. (google.com)
  • 14 . The isolated nucleic acid of any one of claims 1 - 13 , wherein the stabilization of the complex is achieved by one or more cysteine-cysteine bonds that are formed between the surface and transmembrane proteins and that are not present in the corresponding wildtype complex. (google.com)
  • molecules
  • These molecules are contributing to a better understanding of the activity and regulation of apoptotic proteins and also are setting the basis for the discovery of effective drugs to combat important diseases related to apoptosis. (jove.com)
  • We've discovered other single proteins that can link to DNA molecules in 'palindromes', but this is the first time we have seen proteins themselves linked like this. (bio-medicine.org)
  • Antigenic peptides are guided to major histocompatibility complex class I (MHC I) molecules and are finally displayed on the cell surface, where they mount an adaptive immune response against viral infected or malignantly transformed cells. (surrey.ac.uk)
  • CTLs recognize viral antigen-derived peptides (epitopes) presented by major histocompatibility class I (MHC-I) molecules on the surface of viral-infected cells. (frontiersin.org)
  • viruses
  • parasite with a noncellular structure composed mainly of nucleic acid nucleic acid, any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis. (thefreedictionary.com)
  • in the other stage, however, viruses enter living plant, animal, or bacterial cells and make use of the host cell's chemical energy and its protein- and nucleic acid-synthesizing ability to replicate themselves. (thefreedictionary.com)
  • Viruses with such CTL escape mutations often need additional viral genome mutations for recovery of viral fitness. (frontiersin.org)
  • All viruses in this order have icosahedral or oblate heads but differ in the length and contractile abilities of their tails. (wikipedia.org)
  • Siphoviridae constitute the majority of the known tailed viruses. (wikipedia.org)
  • Parvoviruses (Latin: small viruses) have a 5 kilobase long single-stranded DNA, and they use some of their host's replication proteins to copy their DNA. (wikipedia.org)
  • Viruses include in the family Virgaviridae are characterized by unique alpha-like replication proteins. (wikipedia.org)
  • translocation
  • In particular, we are interested in molecular machineries that facilitate protein and peptide translocation across eukaryotic membranes. (surrey.ac.uk)
  • In light of its important role within the MHC I antigen processing pathway, TAP is a prime target for viral immune evasion strategies, and we summarize how this antigen translocation machinery is sabotaged by viral factors. (surrey.ac.uk)
  • We investigate transport and uncoating of the viral capsid, reverse transcription of the viral genome and nuclear translocation of the resulting complex in different target cells. (g-f-v.org)
  • facilitate
  • Thus, analysis of structural and functional constraints in viral proteins could facilitate determination of effective CTLs that can limit viral escape options, contributing to immunogen design in development of CTL-inducing AIDS vaccines. (frontiersin.org)
  • Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest. (uniprot.org)
  • peptides
  • Progress in the knowledge of the structure of many of the main molecular actors of the apoptotic signal transduction pathways has driven the design of synthetic peptides that in some cases can function as simplified versions of their parent proteins. (jove.com)
  • Most applications of peptides in apoptosis research are so far related to caspases, caspase regulatory proteins, such as LAPs and Smac, and proteins of the Bcl-2 family. (jove.com)
  • Protein homeostasis results in a steady supply of peptides, which are further degraded to fuel protein synthesis or metabolic needs of the cell. (surrey.ac.uk)
  • recruitment
  • The SCF E3 ubiquitin-ligase complex participates in the recognition and recruitment of target proteins for ubiquitination and degradation by the ubiquitin 26S proteasome system (UPS). (mdpi.com)
  • nucleic
  • The nucleic acid specifies information for the synthesis of from a few to 50 different proteins, depending on the type of virus. (thefreedictionary.com)
  • 6 . The isolated nucleic acid of claim 3 , wherein the viral surface protein is gp120 or a modified form of gp120, wherein the modification alters the immunogenicity of the molecule relative to wild type gp120. (google.com)
  • motif
  • The F-box domain is a protein structural motif of about 50 amino acids that mediates protein-protein interactions. (mdpi.com)
  • This domain does not contact RNA, and instead, it recognizes 15 residues sequences that are a part of the PABP interaction motif (PAM-2) found on such proteins as eukaryotic translation termination factor (eRF3) and PABP interacting proteins 1 and 2 (PAIP 1, PAIP2). (wikipedia.org)
  • degradation
  • The F-box protein is one of the four components of the SCF (SKp1, Cullin, F-box protein) complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome, playing an essential role in many cellular processes. (mdpi.com)
  • epitopes
  • Recombinant trimeric viral spikes are promising vaccine candidates as they display less non-neutralising epitopes than recombinant monomeric gp120 which act to suppress the immune response to target epitopes. (wikipedia.org)
  • mutations
  • Under the CTL pressure, viral CTL escape mutations are frequently selected with viral fitness costs. (frontiersin.org)
  • HIV/SIV transmission to HLA/MHC-mismatched hosts drives further viral genome changes including additional CTL escape mutations and reversions under different CTL pressure. (frontiersin.org)
  • The engineered DNA was designed to be easier to work with in a number of ways: individual functional elements were separated by restriction endonuclease sites for simple modification, and overlapping protein coding domains were separated and, where necessary, modified by single base pair silent mutations. (wikipedia.org)
  • host
  • On the other hand, F-box proteins can be used in the defense response by the host. (mdpi.com)
  • This review describes the role of F-box proteins and the use of the ubiquitin-proteasome system in virus-host interactions. (mdpi.com)
  • Understanding of viral structure/function and host CTL responses would contribute to prediction of HIV evolution and control of HIV prevalence. (frontiersin.org)
  • Translation using host cell machinery produces new viral components to be assembled. (wikipedia.org)
  • The virus exits the host cell by lysis, and holin/endolysin/spanin proteins. (wikipedia.org)
  • Other parvoviruses replicate only when the host cell is in S phase: viral replication results in the death of the host cell. (wikipedia.org)
  • Expression of the viral proteins alone does not cause host cell death. (wikipedia.org)
  • The host DNA recombination machinery or the cre enzyme translated from the viral DNA recombine the terminally redundant ends and circularize the genome. (wikipedia.org)
  • enzymes
  • The single-strand RNA is tightly bound to p17 nucleocapsid proteins, late assembly protein p6, and enzymes essential to the development of the virion, such as reverse transcriptase and integrase. (wikipedia.org)
  • molecule
  • Wilmanns' lab and the team of Mathias Gautel, an EMBL alumnus and now at King's College, have thought that a molecule called titin, the largest protein made by human cells, is involved. (bio-medicine.org)
  • Peijian Zou and Nikos Pinotsis from the Wilmanns lab obtained crystals of parts of the titin molecule bound to another protein, called telethonin. (bio-medicine.org)
  • reduction
  • This suggests a possibility that the GagD205E substitution in SIVmac239 results in larger reduction of viral fitness than GagL216S. (frontiersin.org)
  • functional
  • and small drugs and actin-binding proteins strongly influence the functional properties of monomeric (G) as well as filamentous (F) actin in vitro. (rupress.org)
  • 2014) Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid. (g-f-v.org)
  • interactions
  • Besides the F-box domain, other domains and motifs related to protein-protein interactions are usually present in the C -terminal region of FBPs, such as leucine rich repeats (LRR), WD40 repeats (WD), Kelch repeats, proline-rich and others. (mdpi.com)
  • The Department of Infectious Diseases, Virology at the University Hospital Heidelberg, Germany offers positions for PhD students working on Lipid-protein interactions in HIV-1 assembly, on High resolution analysis of early HIV-1 replication or on Dynamics of HIV-1 post-entry events in the groups of Prof. Dr. Hans-Georg Kräusslich and Prof. Dr. Barbara Müller . (g-f-v.org)
  • Since the two central β-strands are used for poly(A) oligonucleotide binding, the other face of the protein is free for protein-protein interactions. (wikipedia.org)