• residues
  • There are three major isoforms of APP resulting from alternative splicing, named as APP695, APP751 and APP770 according to their number of amino acid residues. (frontiersin.org)
  • CERT is a 68kDa protein that consists of three different parts, each of which with a special role: Pleckstrin homology domain (PH): It is the aminoterminal domain and it consists of about 100 aminoacid residues. (wikipedia.org)
  • START domain: It consists of about 210 amino acid residues and has an important role in the transfer of ceramide, which is that it can recognize specifically only the natural D-erythro isomer of ceramide and extract it from the membrane. (wikipedia.org)
  • This precursor contains an N-terminal signal peptide, spacer, secretin itself (residues 28-54), and a 72-amino acid C-terminal peptide. (wikipedia.org)
  • encodes
  • The gene that encodes the human EHD3 protein is located in chromosome number 2, most specifically in the 23.1 region. (wikipedia.org)
  • This gene encodes a kinase also known as Goodpasture antigen-binding protein that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. (wikipedia.org)
  • molecular
  • We are using molecular, genetic and biochemical approaches to better define the normal function of sialin and to determine how loss of sialin function leads to neurodevelopmental defects and neurodegeneration associated with the lysosomal free sialic acid storage disorders. (stanford.edu)
  • This protein has a molecular mass of 60887 Daltons. (wikipedia.org)
  • A decade later molecular genetic tools have improved methods for protein identification. (wikipedia.org)
  • The mature secretin peptide is a linear peptide hormone, which is composed of 27 amino acids and has a molecular weight of 3055. (wikipedia.org)
  • neuronal
  • GTRAP3-18 serves as a negative regulator of Rab1 in protein transport and neuronal differentiation. (nih.gov)
  • Thus, we propose a model where protein trafficking and neuronal differentiation are directly linked by the interaction of Rab1 and its regulator GTRAP3-18. (nih.gov)
  • Thus, Pincher-dependent macroendocytosis leads to the formation of Nogo-A signaling endosomes, which act both within growth cones and after retrograde transport in the cell body to negatively regulate the neuronal growth program. (rupress.org)
  • Tyrosine
  • The metabolic pathway is: Phenylalanine → Tyrosine → L-DOPA → Dopamine → Norepinephrine Thus the direct precursor of norepinephrine is dopamine, which is synthesized indirectly from the essential amino acid phenylalanine or the non-essential amino acid tyrosine. (wikipedia.org)
  • These amino acids are found in nearly every protein and, as such, are provided by ingestion of protein-containing food, with tyrosine being the most common. (wikipedia.org)
  • The primary and minor metabolic pathways respectively are: Primary: L-Phenylalanine → L-Tyrosine → L-DOPA → Dopamine Minor: L-Phenylalanine → L-Tyrosine → p-Tyramine → Dopamine Minor: L-Phenylalanine → m-Tyrosine → m-Tyramine → Dopamine The direct precursor of dopamine, L-DOPA, can be synthesized indirectly from the essential amino acid phenylalanine or directly from the non-essential amino acid tyrosine. (wikipedia.org)
  • These amino acids are found in nearly every protein and so are readily available in food, with tyrosine being the most common. (wikipedia.org)
  • Mice
  • High-intensity interval exercise (5 days weekly for 7 weeks), as well as L-lactate subcutaneous injection that leads to an increase in blood lactate levels similar to exercise, increases brain VEGFA protein and capillary density in wild-type mice, but not in knockout mice lacking HCAR1. (uio.no)
  • sequence
  • We sequenced the human VIAAT gene and determined that the human and rat proteins share over 98% sequence identity. (diabetesjournals.org)
  • The deduced amino acid sequence of the protein showed an extended N-terminus, which includes a putative chloroplast transit peptide. (jove.com)
  • It has high sequence similarity to another TGF beta binding protein, beta-glycan, which was one of the first cues that indicated that endoglin is a TGF beta binding proteins. (wikipedia.org)
  • The sequence of amino acids in secretin is H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2. (wikipedia.org)
  • gene
  • These diseases are the result of a defect in transport of sialic acid across lysosomal membranes and are associated with mutations in the gene encoding the sialic acid transporter sialin. (stanford.edu)
  • Eps15 homology domain-containing protein 3, abbreviated as EDH3 and also known as PAST3, is a protein encoded by the EHD3 gene. (wikipedia.org)
  • X-ray crystallographic structures of human endoglin (PDB: 5I04, 5HZV​) and its complex with ligand BMP-9 (PDB: 5HZW​) revealed that the orphan region of the protein consists of two domains (OR1 and OR2) with a new fold resulting from gene duplication and circular permutation. (wikipedia.org)
  • Collagen type IV alpha-3-binding protein, also known as ceramide transfer protein (CERT) or StAR-related lipid transfer protein 11 (STARD11) is a protein that in humans is encoded by the COL4A3BP gene. (wikipedia.org)
  • The β-adrenoceptor was the first G protein-coupled receptor the gene of which was cloned. (wikipedia.org)
  • hydrochloric acid
  • Because of the increased stability and water-solubility of the protonated form, dopamine is supplied for chemical or pharmaceutical use as dopamine hydrochloride-that is, the hydrochloride salt that is created when dopamine is combined with hydrochloric acid. (wikipedia.org)
  • the acidity is due to hydrochloric acid in the chyme that enters the duodenum from the stomach via the pyloric sphincter. (wikipedia.org)
  • phosphorylation
  • Hence, its unspecific interference with photosynthetic membranes in vitro suggests that the inhibitory effect observed on intact cell photosynthesis is caused by uncoupling of phosphorylation. (diva-portal.org)
  • Thus, APP phosphorylation, transport of the generated pAPP into neurites, and neurite extension are interdependent processes regulated by JIP-3/JNK, in a pathway distinct from stress-activated JNK signaling. (jneurosci.org)
  • suggesting that phosphorylation might regulate APP transport into neurites. (jneurosci.org)
  • We also found that JNK-interacting protein-3 (JIP-3), a JNK scaffolding protein that does not directly interact with APP, facilitates this phosphorylation and induces neurite elongation. (jneurosci.org)
  • secretion
  • Secretin helps regulate the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate from the centroacinar cells and intercalated ducts of the pancreas. (wikipedia.org)
  • Also, the secretion of secretin is increased by the products of protein digestion bathing the mucosa of the upper small intestine. (wikipedia.org)
  • Secretin release is inhibited by H2 antagonists, which reduce gastric acid secretion. (wikipedia.org)
  • viaat
  • In vitro expression of VIAAT and immunoblotting of brain and islet lysates revealed two forms of the protein: an ∼52-kDa and an ∼57-kDa form. (diabetesjournals.org)
  • Norepinephrine
  • Dopamine is then converted into norepinephrine by the enzyme dopamine β-monooxygenase (formerly known as dopamine β-hydroxylase), with O2 and ascorbic acid as cofactors. (wikipedia.org)
  • dopamine
  • L-DOPA is converted into dopamine by the enzyme aromatic L-amino acid decarboxylase (also known as DOPA decarboxylase), with pyridoxal phosphate as a cofactor. (wikipedia.org)
  • vitro
  • Electron transfer from excited chlorophyll to ANT is impossible due to the very low reduction potential of ANT and therefore we propose that toxic concentrations of ANT increase the thylakoid membrane permeability and thereby function as an uncoupler, enhancing electron transport in vitro. (diva-portal.org)
  • functional
  • Protein post-translational modifications (PTM) increase the functional diversity of the proteome by the covalent addition of functional groups or proteins, by the hydrolisis of peptide bonds that link amino acids together or by the degradation of different parts of the protein. (wikipedia.org)
  • inhibits
  • More specifically, this drug inhibits the ATP-dependent transport of ceramide from ER to Golgi (and therefore the conversion of ceramide to sphingomyelin), but it does not inhibit protein trafficking. (wikipedia.org)