• involved in neurotransmitter
  • These quantitative results extend our previous studies on the differential expression of presynaptic proteins involved in neurotransmitter release in GABAergic and glutamatergic terminals and indicate that heterogeneity of the respective release machineries can be generated by the differential complement of SV proteins involved in distinct stages of the release process. (frontiersin.org)
  • inhibition
  • Mutations in the C9ORF72 gene lead to inhibition of the formation of the C9ORF72 protein preventing the active transport of the autophagsome leading to inhibition of autophagy. (wikipedia.org)
  • It has also been observed in withdrawn rats that a decrease in Group 2 mGluR inhibition of vesicular release, most likely due to the decrease in extrasynaptic glutamate levels, leads to an increase in cocaine-evoked glutamate signaling in their NAcc. (wikipedia.org)
  • physiological
  • Protective physiological functions of drug-transporting P-glycoproteins (ABCB1), i.a. in the blood-brain barrier (23) and in the gut (oral availability of drugs) (24) (25). (wikipedia.org)
  • vglut2
  • Higher magnifications of the approximate area framed by the white square are shown to the right, together with either gad1b/2 (C,F) or vglut2 (D,G) staining. (nih.gov)
  • EAATs
  • There are two general classes of glutamate transporters, those that are dependent on an electrochemical gradient of sodium ions (the EAATs) and those that are not (VGLUTs and xCT). (wikipedia.org)
  • VGLUTs have only between one hundredth and one thousandth the affinity for glutamate that EAATs have. (wikipedia.org)
  • glial cells
  • Subtypes EAAT1-2 are found in membranes of glial cells (astrocytes, microglia, and oligodendrocytes). (wikipedia.org)