Vesicular biogenic amine transport proteins. Medical search. Frequent questions

Norepinephrine, NE) Indolamines: Serotonin (5-HT) Melatonin (MT) Trace amines Phenethylamines (related to catecholamines): Phenethylamine (PEA) N-Methylphenethylamine (endogenous amphetamine isomer) Phenylethanolamine m-Tyramine p-Tyramine 3-Methoxytyramine N-Methyltyramine m-Octopamine p-Octopamine Synephrine Tryptamine Specific transporter proteins called monoamine transporters that transport monoamines in or out of a cell exist. (wikipedia.org)
In mammals, vesicular monoamine transporters (VMATs) are expressed exclusively in neurons and mediate the storage of histamine and other monoamines. (wikipedia.org)
In PC12 cells, the vesicular acetylcholine transporter (VAChT) localizes preferentially to synaptic-like microvesicles (SLMVs), whereas the closely related vesicular monoamine transporters (VMATs) localize preferentially to large dense core vesicles (LDCVs). (bvsalud.org)
Studies using electrophysiology and radioactive-labeled dopamine have confirmed that the dopamine transporter is similar to other monoamine transporters in that one molecule of neurotransmitter can be transported across the membrane with one or two sodium ions. (cloudfront.net)

A family of neurotransmitter transporter proteins that are INTEGRAL MEMBRANE PROTEINS of the LIPID BILAYER of SECRETORY VESICLES. (uams.edu)
A family of vesicular neurotransmitter transporter proteins that were originally characterized as sodium dependent inorganic phosphate cotransporters. (uchicago.edu)

The dopamine transporter ( DAT ) also ( sodium-dependent dopamine transporter ) is a membrane-spanning protein coded for in the human by the SLC6A3 gene , (also known as DAT1 ), that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol . (cloudfront.net)
DAT is an integral membrane protein that removes dopamine from the synaptic cleft and deposits it into surrounding cells, thus terminating the signal of the neurotransmitter. (cloudfront.net)

Vesicular Neurotransmitter Transport Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
They are ANTIPORTERS that exchange vesicular PROTONS for cytoplasmic NEUROTRANSMITTER and play an essential role in regulating neurotransmission. (uams.edu)
This graph shows the total number of publications written about "Vesicular Neurotransmitter Transport Proteins" by people in UAMS Profiles by year, and whether "Vesicular Neurotransmitter Transport Proteins" was a major or minor topic of these publications. (uams.edu)
Below are the most recent publications written about "Vesicular Neurotransmitter Transport Proteins" by people in Profiles over the past ten years. (uams.edu)
Vesicular glutamate transport proteins sequester the excitatory neurotransmitter GLUTAMATE from the CYTOPLASM into SECRETORY VESICLES in exchange for lumenal PROTONS. (uchicago.edu)
To determine which drugs might specifically potentiate neurotransmitter release, we performed an additional secondary screen for drugs that require presynaptic amine storage to rescue larval locomotion. (bvsalud.org)

Vesicular transport proteins package classical neurotransmitters for regulated exocytotic release, and localize to at least two distinct types of secretory vesicles. (bvsalud.org)
Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. (idrblab.net)

They are deactivated in the body by the enzymes known as monoamine oxidases which clip off the amine group. (wikipedia.org)
These are the dopamine transporter (DAT), serotonin transporter (SERT), and the norepinephrine transporter (NET) in the outer cell membrane and the vesicular monoamine transporter (VMAT1 and VMAT2) in the membrane of intracellular vesicles. (wikipedia.org)
To identify new aminergic drugs in vivo, we used a mutation in the Drosophila vesicular monoamine transporter (dVMAT) as a sensitized genetic background and performed a suppressor screen. (bvsalud.org)
The release of biogenic amines from large dense core vesicles (LDCVs) depends on localization of the vesicular monoamine transporter VMAT2 to LDCVs. (bvsalud.org)
We have used adenoviral-mediated transfection to increase expression of the brain vesicular monoamine transporter VMAT2 and presynaptic amperometric recordings to characterize the effects on quantal release. (bvsalud.org)
After intracellular conversion into 11 C-serotonin and uptake into secretory vesicles by vesicular monoamine transporter 2 or biodegradation by monoamine oxidase A (MAO-A) into 11 C-5-hydroxyindoleacetic acid ( 11 C-HIAA), the tracer is rapidly excreted into the urine. (snmjournals.org)

Reserpine is an adrenergic blocking agent used to treat mild to moderate hypertension via the disruption of norepinephrine vesicular storage. (drugbank.com)

The PET ligand 5-hydroxy- l - 11 C-tryptophan ( 11 C-5-HTP) is the biogenic precursor for serotonin and was originally developed to assess the rate of serotonin biosynthesis by dopa decarboxylase (DDC) in the central nervous system ( 6 ). (snmjournals.org)

Age-related gene expression profiles of the short-lived model animals Caenorhabditis elegans and Drosophila melanogaster share a common adult-onset expression program of genes involved in mitochondrial metabolism, DNA repair, catabolism, peptidolysis and cellular transport 3 . (nature.com)

NSY-1 is in the highly conserved p38 MAP kinase pathway, which plays a crucial role in C. elegans innate immunity, suggesting that this pathway may play a role in biogenic amine toxicity system damage due to amphetamines and in the pathogenesis of Parkinson's disease in higher organisms. (stanford.edu)

Below are the most recent publications written about "Receptors, G-Protein-Coupled" by people in Profiles. (rush.edu)

Evidence for the associations between DAT and dopamine related disorders has come from a type of genetic polymorphism , known as a variable number tandem repeat , in the SLC6A3 gene, which influences the amount of protein expressed. (cloudfront.net)
DAT function requires the sequential binding and co-transport of two Na + ions and one Cl − ion with the dopamine substrate. (cloudfront.net)
Once dopamine binds, the protein undergoes a conformational change, which allows both sodium and dopamine to unbind on the intracellular side of the membrane. (cloudfront.net)
In download Dopamine in the Pathophysiology and Treatment of Schizophrenia: to find the place of here shown early ligands, Rev clusters between the synthesis and storage-inducing resulting body homodimer protein proteins( suggested in Li et al. (evakoch.com)

11 C-5-HTP is currently in clinical use for localization of neuroendocrine tumors (NETs) ( 7 , 8 ) because of the high uptake in these lesions due to the proposed amine precursor uptake and decarboxylase mechanism. (snmjournals.org)

There was also an upregulation in expression of positive regulators and key components of the AMPK pathway, autophagy, proteasome function, and the unfolded protein response. (nature.com)
Previous analyses suggest that lack of normal cilia causes the small-body phenotype through the activation of a signaling pathway which consists of the EGL-4 cGMP-dependent protein kinase and the GCY-12 receptor-type guanylyl cyclase. (stanford.edu)
high bacteria are as proteins of pathway ATM rise, either as acids for greenhouse initiation or for the dehydrogenase of binding eIF2 disorders. (evakoch.com)
After vascular complex pathway is caused on a Electrical snRNP, MAML( other) radicals direct in brain with cyclin C, including protein of followed high-affinity ligands in TAD and PEST cilia of NICD1 by CDK8. (evakoch.com)

Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database. (idrblab.net)

We fed dVMAT mutant larvae â ¼ 1000 known drugs and quantitated rescue (suppression) of an amine-dependent locomotor deficit in the larva. (bvsalud.org)
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs ( Brief Bioinform, 21: 649-662, 2020 ). (idrblab.net)

Methamphetamine decreases K+ channel function in human fetal astrocytes by activating the trace amine-associated receptor type-1. (rush.edu)

Hits common to both data sets indicate disrupted cellular metabolism, calcium signaling, protein stability, DNA binding, and cytoskeletal cell structure. (biomedcentral.com)

The gene that encodes the DAT protein is located on chromosome 5 , consists of 15 coding exons , and is roughly 64 kbp long. (cloudfront.net)
chb-3 encodes a novel protein, with a zf-MYND motif and ankyrin repeats, that is highly conserved from worm to human. (stanford.edu)

Advances in mass spectrometry-based proteomics have facilitated recent interest in the examination of global protein expression to better understand the biology between transcriptional and translational regulation. (biomedcentral.com)

Here we have taken advantage of the Caenorhabditis elegans nematode model system to investigate genetic modifiers of biogenic amine toxicity. (stanford.edu)

In addition to confirming previous works regarding mRNA expression in Mecp2 -deficient animals, the current study identified hundreds of novel protein targets. (biomedcentral.com)

Chronic rhinosinusitis with nasal polyps is characterized by B-cell inflammation and EBV-induced protein 2 expression. (rush.edu)

Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)

In vivo electroporation and non-protein based screening assays to identify antibodies against native protein conformations. (rush.edu)

The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target's druggability. (idrblab.net)

Requisite for vesicular amine storage prior to secretion via exocytosis. (idrblab.net)

Uptake of 11 C-5-HTP in the normal human pancreas is generally high, but this has not previously been systematically investigated despite the fact that islets and some neuronal tissue constitute the only amine precursor uptake and decarboxylase tissue within the pancreas. (snmjournals.org)

Several selected protein targets were validated by Western blot analysis. (biomedcentral.com)

These compounds generally penetrate cell membranes, act on specific target proteins in cells, regulate intracellular signaling pathways, and cause some changes in cell phenotype. (chemscene.com)

Biogenic amine systems are damaged by amphetamine abuse and in Parkinson's disease. (stanford.edu)

Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. (idrblab.net)
0.005 and outside the protein families of the target. (idrblab.net)

These results also suggest the coupling of RACK1 to muscle unfolded protein response during SC activation. (sdbonline.org)

Levels of proteins, including Cyt C, Bcl-2/BAX, and Nrf2 /HO-1-associated proteins, were determined by western blotting and immunofluorescence. (sdbonline.org)

They share a common structure and signal through HETEROTRIMERIC G-PROTEINS. (rush.edu)

NICD1, which not is a skeletal focus, can be controlled by docking to the hormone-bound addition 1-alpha( HIF1A) which serves in the protein when amine homodimers are progressive. (evakoch.com)

These studies have also shown that transport rate and direction is totally dependent on the sodium gradient. (cloudfront.net)

Chemicals and Drugs9

Phenomena and Processes1

Transporters4

Transporter proteins2

Synaptic2

Neurotransmitter6

Neurotransmitters2

Monoamine6

Norepinephrine1

Serotonin1

Drosophila1

Amphetamines1

Receptors1

Dopamine4

Localization1

Pathway4

Descriptors1

Drugs2

Trace1

Metabolism1

Encodes2

Biology1

Genetic1

Novel protein1

Inflammation1

Expression1

Vivo1

Interactions1

Storage1

Tissue1

Targets1

Specific1

Systems1

Target2

Unfolded protein1

Levels1

Structure1

Addition1

Studies1