Vecuronium bromide has been used as part of a drug cocktail that prisons in the United States use for execution by lethal injection. (wikipedia.org)
Vecuronium Bromide for Injection is a nondepolarizing neuromuscular blocking agent of intermediate duration, chemically designated as 1-(3α,17β-Dihydroxy-2β-piperidino-5α-androstan-16β,5α-yl)-1-methylpiperidinium bromide, diacetate. (nih.gov)
Vecuronium Bromide for Injection is supplied as a sterile nonpyrogenic freeze-dried buffered cake of very fine microscopic crystalline particles for intravenous injection only. (nih.gov)
An initial vecuronium bromide dose of 0.08 to 0.1 mg/kg generally produces first depression of twitch in approximately 1 minute, good or excellent intubation conditions within 2.5 to 3 minutes, and maximum neuromuscular blockade within 3 to 5 minutes of injection in most patients. (nih.gov)
Vecuronium Bromide Injection is a non-depolarizing NMB agent of intermediate duration that is not currently authorized for use in Canada. (canada.ca)
However, given the medical necessity of NMBs Health Canada has added US-labelled Vecuronium Bromide for Injection 10mg in a fliptop vial (1 mg/mL when reconstituted to 10 mL) to the List of Drugs for Exceptional Importation and Sale. (canada.ca)
Please see Appendix A for images of US-Labelled Vecuronium Bromide Injection. (canada.ca)
Health Canada has added Vecuronium Bromide for Injection to this list, which permits the importation and sale of US-labelled Vecuronium Bromide for Injection. (canada.ca)
Any case of serious or unexpected side effects in patients receiving Vecuronium Bromide for Injection should be reported to Pfizer Canada ULC or Health Canada. (canada.ca)
Sun Pharmaceutical Industries, Ltd. is voluntarily recalling three lots of Vecuronium Bromide for Injection, 10 mg (lyophilized powder), and one lot of Vecuronium Bromide for Injection, 20 mg (lyophilized powder) to the hospital level. (defaakto.com)
VECURONIUM SUN vecuronium bromide 10mg powder for injection vial - medicine shortage information. (ccpl.org)
SAN FRANCISCO, April 14, 2017 - Today, McKesson Corporation was granted a temporary restraining order by the Circuit Court of Pulaski County Arkansas that prohibits the Arkansas Department of Correction from using vecuronium bromide obtained by McKesson for lethal injection purposes until otherwise notified by the Court. (mckesson.com)
Oklahoma uses a three-drug lethal injection method starting with the sedative midazolam, rendering the person unconscious, followed by a paralytic vecuronium bromide and finally potassium chloride, which stops the heart. (typepad.com)
Our range of products include ascorbic acid injection 250 mg/ml, rocuronium bromide injection(10mg) mycuronium, cerebroprotein hydrolysate injection, artemether injection 80 mg, ascorbic acid injection 100 mg/ml and vecuronium bromide for injection ( for export). (mayabiotech.co.in)
Vecuronium bromide for injection 10 mg per vial and 20 mg per vial and rocuronium bromide injection 50 mg/5 mL, 100 mg/10 mL, commonly used to provide muscle relaxation during surgery or mechanical ventilation, usually include a warning statement embossed on the vial cap to identify the product as a paralyzing agent. (ncbop.org)
For that execution, the state used the well-established, "traditional" three-drug lethal injection cocktail: sodium thiopental, pancuronium bromide, and potassium chloride. (stanford.edu)
Pancuronium bromide1
Optimization of the aminosteroid nucleus led to a sequence of synthesized derivatives, ultimately leading to pancuronium bromide in 1964. (wikipedia.org)
Midazolam5
According to a news release, Oklahoma has obtained a "reliable supply" of drugs that will continue to be used, including midazolam, vecuronium bromide, and potassium chloride. (thedailybeast.com)
The state executed Grant using a controversial drug cocktai l consisting of midazolam, a sedative, vecuronium bromide, a paralytic, and potassium chloride, which stops the heart. (kfor.com)
The state uses a combination of three drugs -- midazolam, vecuronium bromide, and potassium chloride -- to render an inmate unconscious, and then to stop the inmate's breathing, and finally, his (or her) beating heart. (wonkette.com)
Without access to pentobarbital, the state resorted to rocuronium bromide, potassium chloride, and midazolam-the latter of which has been at the center of much debate. (pharmacytimes.com)
3 By 2015, the state was forced to retreat, deciding this time to adopt another three-drug cocktail that was actively being used by other states: a sedative named midazolam was to be injected at the start of the execution, followed by two other drugs-vecuronium bromide and potassium chloride. (stanford.edu)
Paralytic1
His execution was otherwise put on hold Wednesday by Circuit Judge Alice Gray, who barred the prison from using its supply of vecuronium bromide, a paralytic, in executions. (arkansasonline.com)
Vial2
Each vial contains 10 mg or 20 mg of vecuronium bromide, USP. (nih.gov)
Vecuronium is used to paralyze the prisoner and stop his or her breathing, in conjunction with a sedative and potassium chloride to stop the prisoner's heart. (wikipedia.org)
Vecuronium bromide paralyzes the prisoner's breathing. (crisismagazine.com)
Sedative1
Instead of giving the patient Versed, a common sedative, Ms. Vaught says she accidentally administered vecuronium bromide - a powerful paralyzer intended to keep patients still during surgery - after performing an override on the hospital's electronic medication cabinet. (beckershospitalreview.com)
Injections1
Injections of vecuronium bromide without proper sedation allow the person to be fully awake but unable to move in response to pain. (wikipedia.org)
Neuromuscular8
Vecuronium is in the aminosteroid neuromuscular-blocker family of medications and is of the non-depolarizing type. (wikipedia.org)
medical citation needed] The neuromuscular blocking action of vecuronium is slightly enhanced in the presence of potent inhalation anesthetics. (wikipedia.org)
Vecuronium is a nondepolarizing neuromuscular blocking agent possessing all of the characteristic pharmacological actions of this class of drugs (curariform). (nih.gov)
Prior administration of succinylcholine may enhance the neuromuscular blocking effect of vecuronium and its duration of action. (nih.gov)
With succinylcholine as the intubating agent, initial doses of 0.04 to 0.06 mg/kg of vecuronium bromide will produce complete neuromuscular block with clinical duration of action of 25 to 30 minutes. (nih.gov)
Repeated administration of maintenance doses of vecuronium has little or no cumulative effect on the duration of neuromuscular blockade. (nih.gov)
Potassium chloride to stop1
Brooks also received 600 mg of rocuronium bromide to stop his breathing and 240 mEq of potassium chloride to stop his heart. (pharmacytimes.com)
Patients1
In 2001, Japanese nurse Daisuke Mori was reported to have murdered 10 patients using vecuronium bromide. (wikipedia.org)
Cocktail1
Gray's ruling in effect would stop any executions from taking place because vecuronium bromide is one of the drugs in the three-drug cocktail used in executions under state law. (arkansasonline.com)
Brand1
Vecuronium bromide, sold under the brand name Norcuron among others, is a medication used as part of general anesthesia to provide skeletal muscle relaxation during surgery or mechanical ventilation. (wikipedia.org)
Administration2
Reversal of vecuronium can be accomplished by administration of sugammadex which is a γ-cyclodextrin which encapsulates vecuronium preventing it from binding to receptors. (wikipedia.org)
For information on appropriate use of vecuronium bromide including dosage and administration, please refer to the US Vecuronium Bromide Prescribing Information . (canada.ca)
Drug1
Vecuronium bromide is a drug that relaxes skeletal muscles and can be used in conjunction with surgical anesthesia. (crisismagazine.com)
Alert1
Health Canada has worked with Pfizer Canada ULC to prepare this alert for Vecuronium Bromide. (canada.ca)
Effect2
medical citation needed] Vecuronium has an active metabolite, 3-desacetyl-vecuronium, that has 80% of the effect of vecuronium. (wikipedia.org)
The time to onset of paralysis decreases and the duration of maximum effect increases with increasing vecuronium doses. (nih.gov)
Muscle4
Vecuronium operates by competing for the cholinoceptors at the motor end plate, thereby exerting its muscle-relaxing properties, which are used adjunctively to general anesthesia. (wikipedia.org)
A paper published in 1973 discussed the structure-activity relationships of a series of aminosteroid muscle relaxants, including the mono-quaternary analogue of pancuronium, later called vecuronium. (wikipedia.org)
Vecuronium bromide is indicated as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. (canada.ca)
Vecuronium is fitted into a muscle, or into a tone through an IV. (jindalmedicalstore.in)
Execution1
Once it had been administered, the execution team began the flow of vecuronium bromide and potassium chloride. (stanford.edu)