• 6. Antineutrophil cytoplasmic antibodies, ANCA    Cause of ANCA-associated vasculitis (AAV) C-antineutrophil cytoplasmic antibodies (CANCA) against proteinase 3 (PR3) - Associated with GPA and MPA - Disease activity is parallel to C-ANCA titer. (
  • With great interest we read the clinical review by Berden and co-authors regarding ANCA associated vasculitis. (
  • As is known, ANCA associated vasculitis is characterized by necrotizing granulomatous lesions that affect different vessels and organs, most commonly the kidney and lungs. (
  • the involve anti-neutrophil cytoplasmic antibody (ANCA) as a common pathogenesis .They can be detected by indirect immunofluoroscence and 2 staining pattern are known namely : perinuclear ( P-ANCA) and cytoplasmic ( C-ANCA) .he target organs of PANCA is myeloperoxidase (MPO) and for CANCA is proteinase 3(PR3) .These vasculitis leads to multi-organ involvement. (


  • Large vessel vasculitis   Giant cell arteritis Takayasu arteritis 2. (
  • Medium-sized vessel vasculitis   Polyarteritis nodosa Kawasaki disease 3. (


  • Revisiting the classification of clinical phenotypes of anti-neutrophil cytoplasmic antibody-associated vasculitis: a cluster analysis. (


  • In 2006, the patient was diagnosed with Henoch-Schönlein purpura (HSP) on the basis of histological examination of skin biopsy samples, which showed leukocytoclastic vasculitis. (