Valine - Uses, Benefits, Sources and Dosage Valine is a branched chain amino acid and closely related to leucine and isoleucine in both structure and function. (planetayurveda.com)
Several studies have reported the ability of the lactotripeptides valine-proline- proline (VPP) and isoleucine-proline-proline (IPP) to lower systolic blood pressure (SBP), including in Japanese populations. (scirp.org)
Despite their structural similarities, the branched amino acids have different metabolic routes, with valine going solely to carbohydrates, leucine solely to fats and isoleucine to both. (selfdecode.com)
The different metabolism accounts for different requirements for these essential amino acids in humans: 12 mg/kg, 14 mg/kg and 16 mg/kg of valine, leucine and isoleucine respectively. (selfdecode.com)
Valine deficiency is marked by neurological defects in the brain, while isoleucine deficiency is marked by muscle tremors. (selfdecode.com)
Valine is one of three branched-chain amino acids (the others are leucine and isoleucine) that enhance energy, increase endurance, and aid in muscle tissue recovery and repair. (selfdecode.com)
Supplemental valine should always be combined with isoleucine and leucine at a respective milligram ratio of 2:1:2. (selfdecode.com)
This mutation led to a change in the structure of the protein on the surface of the virus, replacing one amino acid, isoleucine, with a different one, valine. (cdc.gov)
The valine at position 82 (ABL 84) was changed to isoleucine and the alanine at position 182 (ABL 184) was changed to valine. (lu.se)
Amino acid15
Valine (symbol Val or V) is an α-amino acid that is used in the biosynthesis of proteins. (wikipedia.org)
An amino acid oxidoreductase that catalyzes the oxidative hydroxylation of L-VALINE to 3-methyl-2-oxobutanoate and AMMONIA in the presence of NADP . (online-medical-dictionary.org)
The surface of α-manganese dioxide (α-MnO 2 ) nanorods was modified chemically with L -valine amino acid by a solvothermal strategy. (rsc.org)
Thus valine, a hydrophic amnio acid, replaces glutamic acid, a hydrophilic amino acid, causing hemoglobin to not fold correctly. (loinc.org)
Valine is a branched-chain amino acid that stimulates activity and promotes muscle growth and tissue repair. (loinc.org)
The goals of these trials were to investigate the effects of different dietary amino acid concentrations and valine:lysine ratios on piglet performance and health. (agrarforschungschweiz.ch)
The supplementation of the essential amino acid valine did not affect performance or animal health in either trial. (agrarforschungschweiz.ch)
L-valine is a branched-chain essential amino acid (BCAA) that has stimulant activity. (selfdecode.com)
In sickle-cell disease, valine substitutes for the hydrophilic amino acid glutamic acid in hemoglobin. (selfdecode.com)
Valine is an essential amino acid, hence it must be ingested, usually as a component of proteins. (selfdecode.com)
Valine is an essential branched chain amino acid (BCAA) that promotes muscle repair and growth. (myfooddata.com)
Our L-Valine is a pure and potent form of the amino acid that can be taken as part of a daily supplement regimen or used before, during, or after physical activity. (bulksupplements.com)
Research studies have found that branched-chain amino acids (BCAAs) are associated with diabetes and obesity , and the branched-chain amino acid valine is the culprit! (advancedmolecularlabs.com)
The branched-chain amino acid valine had the highest risk prediction of incidents of type 2 diabetes! (advancedmolecularlabs.com)
Valine is a glucogenic amino acid, meaning it can create and/or be converted into glucose 1,2 . (muscleandstrength.com)
Leucine1
Unfortunately for valine, it is far less effective at this than Leucine (a theme that repeats itself). (muscleandstrength.com)
Threonine1
Located in Tongliao, Inner Mongolia, theplant of threonine, capacity currently is 250,000 tonnes/year and there will havea production capacity of 21,811 tonnes/year of valine after the project iscompleted. (agromate.com)
Methyl carbons2
According to IUPAC, carbon atoms forming valine are numbered sequentially starting from 1 denoting the carboxyl carbon, whereas 4 and 4' denote the two terminal methyl carbons. (wikipedia.org)
The methyl carbons of valine can be utilized to produce glucose and ultimately glycogen. (muscleandstrength.com)
Proteinogenic amino acids1
Valine, one of the 20 proteinogenic amino acids, is nutritionally essential. (loinc.org)
BCAA1
Mice fed a BCAA-deprived diet for one day had improved insulin sensitivity, and feeding of a valine-deprived diet for one week significantly decreases blood glucose levels. (wikipedia.org)
Catabolite3
The valine catabolite 3-hydroxyisobutyrate promotes insulin resistance in mice by stimulating fatty acid uptake into muscle and lipid accumulation. (wikipedia.org)
Recently, the valine catabolite 3-hydroxyisobuterate (3HIB) was shown to promote insulin resistance in skeletal muscle by increasing lipid content in vivo. (advancedmolecularlabs.com)
It was reported in the journal Nature Medicine in 2015 that valine catabolite 3-hydroxyisobuterate (3HIB) promoted the accumulation of fat within muscle tissue by directly stimulating fatty uptake in the muscle. (advancedmolecularlabs.com)
Metabolic1
In this study, we investigated the metabolic effects of γ -glutamyl valine (γ -EV) in diabetic obese mice. (unl.edu)
Dietary3
Dietary valine is essential for hematopoietic stem cell (HSC) self-renewal, as demonstrated by experiments in mice. (wikipedia.org)
Dietary valine restriction selectively depletes long-term repopulating HSC in mouse bone marrow. (wikipedia.org)
The reference dietary intake (RDI) for valine is 26mg per kilogram of body weight or 12mg per pound. (myfooddata.com)
BCAAs2
Valine is one of the three branched-chain amino acids (BCAAs) and is essential for human nutrition. (bulksupplements.com)
Valine is the least researched or well understood of the 3 BCAAs, and as such the currently known biological effects of it are minimal. (muscleandstrength.com)
Glutamic acid1
In sickle cell disease, the replacement of an A by T in the beta chain gene of hemoglobin changes the codon GAG (for glutamic acid) to GTG (which encodes valine). (loinc.org)
20191
In a most recent study in the journal Mediators of Inflammation , on November 11, 2019, researchers undertook a study, "aimed at assessing circulating valine concentrations in subjects with type 2 diabetes," noting that "Circulating valine level might be a novel biomarker for type 2 diabetes. (advancedmolecularlabs.com)
Catabolism1
Enzymes involved in this biosynthesis include: Acetolactate synthase (also known as acetohydroxy acid synthase) Acetohydroxy acid isomeroreductase Dihydroxyacid dehydratase Valine aminotransferase Like other branched-chain amino acids, the catabolism of valine starts with the removal of the amino group by transamination, giving alpha-ketoisovalerate, an alpha-keto acid, which is converted to isobutyryl-CoA through oxidative decarboxylation by the branched-chain α-ketoacid dehydrogenase complex. (wikipedia.org)
Obese1
In diet-induced obese and insulin resistant mice, a diet with decreased levels of valine and the other branched-chain amino acids resulted in a rapid reversal of the adiposity and an improvement in glucose-level control. (wikipedia.org)
19012
Valine was first isolated from casein in 1901 by Hermann Emil Fischer. (wikipedia.org)
Valine was discovered in 1901 by Emil Fischer, a German scientist. (planetayurveda.com)
Biomarker1
These valine adducts are considered a biomarker of long-term acrylamide exposure. (cdc.gov)
MeSH1
Valine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
Poultry1
for the production of premixes and enrichment of rations of farm animals and poultry with valine. (ecofeedgroup.ru)
Glucose1
This process of valine oxidation for glucose is increased in skeletal muscle following injury, which suggests that consuming extra valine in times of muscle injury (i.e. heavy training) might be beneficial for muscle recovery. (muscleandstrength.com)
Rats3
By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg).The development of hypertension in ANG II infused rats is prevented by losartan treatment. (medchemexpress.com)
In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). (medchemexpress.com)
Male Sprague Dawley rats are uninephrectomized and divided into three groups: control (n=6), Angiotensin II 5-valine (exogenous form) infused (n=8), and Angiotensin II 5-valine infused rats treat with losartan (n=8). (medchemexpress.com)
Metabolism2
Valaciclovir is rapidly and almost entirely (~99%) converted to the active compound, acyclovir, and L-valine by first-pass intestinal and hepatic metabolism by enzymatic hydrolysis. (selfdecode.com)
Valine metabolite, 3-hydroxyisobutyrate (3- HIB ), also plays an important role in metabolism , whilst its effect has been rarely examined. (bvsalud.org)
Foods1
Below is a list of the top 10 foods highest in valine with the %RDI calculated for someone weighing 70kg (154lbs). (myfooddata.com)
Beans2
γ-Glutamyl Valine, Found in Dry Edible Beans, Is Anti-diabetic in db/" by Bikram Upadhyaya, Kaustav Majumder et al. (unl.edu)
The L-Valine- 15 N is an organic compound with the formula C 5 H 11 NO 2 . (lookchem.com)
Diabetic2
The researchers analyzed blood valine levels in type 2 diabetes after sitagliptin treatment, an anti-diabetic drug. (advancedmolecularlabs.com)
Research has also shown that the anti-diabetic drug metformin can also lower valine in the blood of diabetics. (advancedmolecularlabs.com)
Hemoglobin2
Because valine is hydrophobic, the hemoglobin does not fold correctly. (selfdecode.com)
Both acrylamide and glycidamide react with hemoglobin (HGB), specifically at the N-(2 carbamoylethyl) valine residue of the ß-peptide subunit. (cdc.gov)
Liver3
Valine in particular, has been established as a useful supplemental therapy to the ailing liver. (selfdecode.com)
Additionally, valine supports liver function and promotes gallbladder health. (bulksupplements.com)
L-valine also supports liver function and promotes a healthy gallbladder. (bulksupplements.com)
Mice2
Successful stem cell transplantation was achieved in mice without irradiation after 3 weeks on a valine restricted diet. (wikipedia.org)
Long-term survival of the transplanted mice was achieved when valine was returned to the diet gradually over a 2-week period to avoid refeeding syndrome. (wikipedia.org)
Diabetes3
Valine levels were higher in type 2 diabetes patients, while decreased in sitagliptin monotherapy. (advancedmolecularlabs.com)
These results suggest that valine might be involved in the pathogenesis in type 2 diabetes," the researchers said. (advancedmolecularlabs.com)
Using genetics to examine the overall and sex-specific associations of branch-chain amino acids and the valine metabolite, 3-hydroxyisobutyrate, with ischemic heart disease and diabetes: A two-sample Mendelian randomization study. (bvsalud.org)
Highest1
The top food sources highest in valine. (foodnutri.com)
Muscle1
L-Valine has ability to maintain mental vigor, emotional calm, & muscle coordination. (nutraceuticalproducts.net)
Blood1
Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. (medchemexpress.com)
Effects1
Following this, the effects of α-MnO 2 - L -valine nanorods on the properties of NCs, such as the mechanical and thermal properties, were studied. (rsc.org)