Loading...
  • pyruvate
  • Metabolism is usually divided into two categories: catabolism, the breaking down of organic matter for example, the breaking down of glucose to pyruvate, by cellular respiration, and anabolism, the building up of components of cells such as proteins and nucleic acids. (wikipedia.org)
  • metabolism
  • Amino acids also contribute to cellular energy metabolism by providing a carbon source for entry into the citric acid cycle (tricarboxylic acid cycle), especially when a primary source of energy, such as glucose, is scarce, or when cells undergo metabolic stress. (wikipedia.org)
  • conversion
  • The conversion of glucose to lactate rather than metabolizing it in the mitochondria through oxidative phosphorylation, (which can also occur in hypoxic normal cells) persists in malignant tumor despite the presence of oxygen. (wikipedia.org)
  • high
  • This shift therefore demands that tumor cells implement an abnormally high rate of glucose uptake to meet their increased needs. (wikipedia.org)
  • Human
  • Recently, human UTP-glucose-1-phosphate uridylyltransferase has been studied and crystallized, revealing a different type of regulation than other organisms previously studied. (wikipedia.org)
  • levels
  • Several plant species being a major source of terpenoids, flavonoids, phenolics, coumarins, and other bioactive constituents have shown reduction in blood glucose levels [ 5 , 6 ]. (hindawi.com)
  • sugar
  • A Rossman fold motif participates in binding of the UTP nucleotide and a sugar-binding domain (residues T286-G293) coordinates with the glucose ring. (wikipedia.org)
  • Similar to other sugar nucleotidyltransferases, UTP-glucose-1-phosphate uridylyltransferase activity requires two divalent cations to stabilize the binding of negatively charged phosphate groups. (wikipedia.org)
  • cells
  • In animal cells, UTP-glucose-1-phosphate uridylyltransferase is found predominantly in the cytoplasm. (wikipedia.org)
  • The conversion of glucose to lactate rather than metabolizing it in the mitochondria through oxidative phosphorylation, (which can also occur in hypoxic normal cells) persists in malignant tumor despite the presence of oxygen. (wikipedia.org)
  • This shift therefore demands that tumor cells implement an abnormally high rate of glucose uptake to meet their increased needs. (wikipedia.org)