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  • triphosphate
  • Up 4 A is released from the endothelium in response to acetylcholine (ACh), the calcium ionophore (A23187), endothelin-1, adenosine triphosphate (ATP), uridine triphosphate (UTP), and mechanical stress. (hindawi.com)
  • Combination therapy using nebulized amiloride hydrochloride and uridine-5'-triphosphate (UTP) trisodium salt aerosols has been investigated for the treatment of cystic fibrosis (CF). Amiloride in aqueous solution precipitates in the presence of UTP, reducing drug concentrations. (rti.org)
  • Prodrug
  • NEW HAVEN, Conn., Nov. 2, 2013 (GLOBE NEWSWIRE) -- Achillion Pharmaceuticals, Inc. (Nasdaq:ACHN) today announced a poster presentation detailing the preclinical profile of ACH-3422, a uridine-analog nucleotide prodrug being advanced for the potential treatment of chronic hepatitis C viral infection (HCV). (cnbc.com)
  • bioavailable
  • Although claimed that virtually none of the uridine in this form is bioavailable "since - as shown by Handschumacher's Laboratory at Yale School of Medicine in 1981 - it is destroyed in the liver and gastrointestinal tract, and no food, when consumed, has ever been reliably shown to elevate blood uridine levels', this is contradicted by Yamamoto et al. (wikipedia.org)
  • Non-phosphorylated uridine is not bioavailable beyond first-pass metabolism, as it is almost entirely catabolised in the liver and gastrointestinal tract. (wikipedia.org)
  • ester
  • The present invention relates to novel uridine esters of the general formula ##STR00001## wherein R represents a carboxylic acid residue, preferably a fatty acid residue and R' represents hydrogen or a hydroxy group, their use as pharmaceutically active agents against a variety of diseases, methods for the preparation of said uridine esters and pharmaceutical compositions containing at least one uridine ester as active ingredient. (patentgenius.com)
  • The present invention relates to novel uridine esters, their use as pharmaceutically active agents against a variety of diseases, methods for the preparation of said uridine esters andpharmaceutical compositions containing at least one uridine ester as active ingredient. (patentgenius.com)
  • It is an ester of phosphoric acid with the nucleoside uridine. (wikipedia.org)
  • drugs
  • citation needed] Harvard researchers report that omega-3 fatty acids and uridine, two substances in foods such as fish, walnuts, molasses, and sugar beets, prevented depression in rats as effectively as antidepressant drugs. (wikipedia.org)
  • novel
  • Recently, uridine adenosine tetraphosphate (Up 4 A) has been identified as a novel and potent endothelium-derived contracting factor (EDCF). (hindawi.com)
  • fold
  • plasma uridine levels rose 1.8 fold 30 minutes after beer ingestion, suggesting, at the very least, conflicting data. (wikipedia.org)
  • represents
  • However, thymidine is more commonly written as 'dT' ('d' represents 'deoxy') as it contains a 2'-deoxyribofuranose moiety rather than the ribofuranose ring found in uridine. (wikipedia.org)
  • Combination
  • Giving rats a combination of uridine and omega-3 fatty acids produced immediate effects that were indistinguishable from those caused by giving the rats standard antidepressant medications," said lead author of the study William Carlezon, director of McLean's Behavioral Genetics Laboratory. (wikipedia.org)
  • citation
  • citation needed] Sugarcane extract Tomatoes (0.5 to 1.0 g uridine per kilogram dry weight)[verification needed] Brewer's yeast (1.7% uridine by dry weight) Beer Broccoli Offal (liver, pancreas, etc. (wikipedia.org)
  • present
  • On the other hand, ethanol on its own (which is present in beer) increases uridine levels, which may explain the raise of uridine levels in the study by Yamamoto et al. (wikipedia.org)
  • activity
  • R.K. Johnson, Reversal of toxicity and antitumor activity of N-(phosphonacetyD-L-aspartate by uridine or carbamyl-DL-aspartate in vivo, Biochem. (springer.com)
  • Leyva A., Kraal I., Lankelma J., Pinedo H.M. (1984) High Uridine Catabolic Activity in Cultured Human Melanoma Cells. (springer.com)