• Tegafur
  • Tegafur/uracil is a chemotherapy drug combination used in the treatment of cancer, primarily bowel cancer. (wikipedia.org)
  • It is an oral agent which combines uracil, a competitive inhibitor of DPD, with the 5-fluorouracil (5-FU) prodrug tegafur in a 4:1 molar ratio. (wikipedia.org)
  • In the UK, tegafur/uracil with folinic acid is approved as first line treatment by the National Institute for Health and Clinical Excellence (NICE) for metastatic colorectal cancer. (wikipedia.org)
  • It is made by various manufacturers and sold under a variety of names including: Tegafur-uracil, UFT, Ftorafur, Tefudex, Ufur and Uftoral. (wikipedia.org)
  • Escherichia
  • This study demonstrates that in nondividing Escherichia coli cells, a DNA template base replaced with uracil in a stop codon in the firefly luciferase gene results in conversion of inactive to active luciferase. (sciencemag.org)
  • Oxidative
  • C4H4N2O2 → H3NCH2CH2COO− + NH4+ + CO2 Oxidative degradation of uracil produces urea and maleic acid in the presence of H2O2 and Fe2+ or in the presence of diatomic oxygen and Fe2+. (wikipedia.org)
  • synthesis
  • Uracil-containing DNA still exists, for example in DNA of several phages Endopterygote development Hypermutations during the synthesis of vertebrate antibodies. (wikipedia.org)
  • Stability
  • Uracil undergoes amide-imidic acid tautomeric shifts because any nuclear instability the molecule may have from the lack of formal aromaticity is compensated by the cyclic-amidic stability. (wikipedia.org)
  • Uracil is rarely found in DNA, and this may have been an evolutionary change to increase genetic stability. (wikipedia.org)
  • name
  • Some of the dosage forms listed on this page may not apply to the brand name Uracil. (drugs.com)
  • The name "uracil" was coined in 1885 by the German chemist Robert Behrend, who was attempting to synthesize derivatives of uric acid. (wikipedia.org)
  • include
  • In 2012 an analysis of data from the Cassini mission orbiting in the Saturn system showed that Titan's surface composition may include uracil. (definitions.net)