Unrelated donors. Medical search. Frequent questions

Results of the cord blood transplantation (COBLT) study unrelated donor banking program. (emmes.com)
The goals of the Cord Blood Transplantation (COBLT) Study banking program initiated in 1996 were to develop standard operating procedures (SOPs) for cord blood (CB) donor recruitment and banking and to build an ethnically diverse unrelated CB bank to support a transplantation protocol. (emmes.com)
Matched Related and Unrelated Donor Hematopoietic Stem Cell Transplantation for DOCK8 Deficiency. (gwu.edu)
Guillermo Ortí, MD, PhD, Vall d'Hebron Institute of Oncology, Barcelona, Spain, outlines the rationale and design of a retrospective study exploring the outcomes of patients with chronic myeloid leukemia (CML) undergoing unrelated and haploidentical donor allogeneic hematopoietic stem cell transplantation (alloHSCT) with post-transplant cyclophosphamide (PTCy) prophylaxis compared to a historical cohort of patients who have received unrelated donor alloHSCT with calcineurin inhibitor prophylaxis. (vjhemonc.com)
This, along with the development of unrelated cord blood transplantation and familial haploidentical transplantation methods, have improved the likelihood of finding an appropriate HSCT source in a timely manner. (medscape.com)
Allogeneic stem cell transplantation uses donor stem cells to treat and sometimes cure certain blood disorders and blood cancers. (clevelandclinic.org)
PURPOSE OF REVIEW: The role of hematopoietic cell transplantation in non-malignant disorders has increased exponentially with the recognition that multiple diseases can be controlled or cured if engrafted with donor-derived cells. (wustl.edu)
Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen. (ox.ac.uk)
In summary, a nonmyeloablative regimen incorporating in vivo CAMPATH-1H is effective in promoting durable engraftment in most patients and in reducing the risk of severe GVHD following matched unrelated donor transplantation. (ox.ac.uk)
High-resolution HLA phased haplotype frequencies to predict the success of unrelated donor searches and clinical outcome following hematopoietic stem cell transplantation. (unige.ch)
This clinical trial will randomize 234 children/AYA over 3.3-4.7 years at a 1:1 ratio between initial treatment with immune suppression therapy (IST) with horse ATG (hATG)/cyclosporine (CsA) versus well- matched (9-10/10 allele) unrelated donor (URD) bone marrow transplantation (BMT) using a regimen of rabbit ATG (rATG)/fludarabine/cyclophosphamide and 200 cGy TBI. (ucsf.edu)
Comparable Outcomes of Matched Sibling Donor and Matched Unrelated Donor Stem Cell Transplantation in Children With Acute Leukemia in Argentina. (ox.ac.uk)
Hence the outcome of reduced intensity HSCT with lymphodepleting antibodies in older patients with intermediate/high-risk hematological malignancies appears comparable to that obtained with fully ablative transplantation in younger patients, even when these older recipients lack HLA-identical sibling donors. (nih.gov)
For allogeneic transplantation, the patient receives bone marrow or blood stem cells from a tissue-matched (HLA-matched) donor who may or may not be a relative. (ucsfhealth.org)
Mayo Clinic doctors and surgeons research living-donor transplantation, presenting their work at national and international meetings. (mayoclinic.org)
This is a prospective, multi-center, Phase II study of hematopoietic cell transplantation (HCT) using human leukocyte antigen (HLA)-mismatched unrelated donors (MMUD) for peripheral blood stem cell transplant in adults and bone marrow stem cell transplant in children. (uchicagomedicine.org)
That previous work, in both heart and lung transplantation, relied on genotyping both the organ donor and the recipient in order to distinguish which cfDNA fragments were being shed from the donor organ, and which were naturally occurring from the recipient. (genomeweb.com)
The transplantation of stem cells from a healthy donor (allogeneic) offers the chance of cure for patients with an aggressive form of chronic lymphocytic leukemia (CLL), irrespective of genetic prognostic factors and the prior course of the disease. (disabled-world.com)
Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
Organ Transplantation.2 These Guiding Principles - whose emphases include voluntary donation, noncommercialization, genetic relation of recipients to donors and a preference for cadavers over living donors as sources - have considerably influenced professional codes, national, state and provincial legislation, and the policies of intergovernmental organizations. (who.int)
BACKGROUND: This study aimed to elucidate the effect of early enteral nutrition on graft loss within 12 h after living-donor liver transplantation (LDLT) using propensity score-matching analysis and subsequently examine the risk factors for graft loss after LDLT. (bvsalud.org)
Mapping MHC haplotype effects in unrelated donor hematopoietic cell transplantation. (cdc.gov)
Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)
Allogeneic hematopoietic stem cell transplantation is limited mainly by lack of histocompatible donors. (msdmanuals.com)

This review provides an overview of advances made in alternative donor transplants for nonmalignant disorders. (wustl.edu)
It advocates the consideration of alternative donor transplants in the absence of human leukocyte antigen matched siblings when indicated by disease severity. (wustl.edu)
This recent successful collaboration between the Cleveland Clinic Abu Dhabi and another local hospital to complete three simultaneous transplants further reinforces the UAE's vision, and establishes the country as a preferred healthcare destination in the region for patients seeking a compatible donor, as well as an opportunity to combat kidney failure, the hospital said in a statement. (gulfnews.com)

The three-year survival rates were 85 percent for kidneys from 368 spouses, 81 percent for kidneys from 129 living unrelated donors who were not married to the recipients, 82 percent for kidneys from 3368 parents, and 70 percent for 43,341 cadaveric kidneys. (nih.gov)
The putative impact of haplotypes was then analyzed in a cohort of 211 recipients transplanted with 10/10 matched unrelated donors. (unige.ch)
The programme works with leading hospitals in the region to match transplant recipients with compatible donors. (gulfnews.com)
Dr Bashir Sankari, chair of the hospital's Urology, Surgical Subspecialties Institute explained the process of matching donors and recipients in a paired donation programme. (gulfnews.com)
Two donors were unrelated, but six were siblings of the recipients. (genomeweb.com)
Avoiding and monitoring transfusion-transmissible diseases (TTDs) is crucial to ensure the safety of blood transfusions and protect both donors and recipients. (researchgate.net)
A 1991 investigation determined that several recipients had been infected with HIV by an organ/tissue donor who had tested negative for HIV antibody at the time of donation (4). (cdc.gov)

The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
While both treatments help your bone marrow to develop new blood cells, studies show allogeneic stem cell transplantations work by causing the donor cells to attack unhealthy cells. (clevelandclinic.org)
In April 1973 Hobbs and his team were able to achieve the world's first bone marrow transplant using a matched but unrelated volunteer donor. (wikipedia.org)
With the success of this procedure steps were taken by professor Hobbs's team to set up the world's first unrelated bone marrow donor register. (wikipedia.org)
This study provides useful data for the optimization of unrelated bone marrow donor searches, but does not confirm previous reports that matching at the haplotype level has a clinical impact following HSCT. (unige.ch)
Regular treatment for patients with aplastic anemia who have a matched sibling (brother or sister), or family donor is a bone marrow transplant. (ucsf.edu)
Match unrelated donor (URD) bone marrow transplant (BMT) is used as a secondary treatment in patients who did not get better with IST, had their disease come back, or a new worse disease replaced it (like leukemia). (ucsf.edu)
With a bone marrow transplant, the donor receives general anesthesia , and the bone marrow is extracted in a 1-2-hour procedure. (mdanderson.org)
With a peripheral blood cell transplant, the donor receives growth factor shots to stimulate the bone marrow to push the stem cells into the blood. (mdanderson.org)
People who register as donors agree to donate either bone marrow or PBSC, depending on the recipient's needs. (healthline.com)
Donating bone marrow is relatively low risk for the donor. (healthline.com)
Also the need for more Hispanic bone marrow donors in Arizona. (azpbs.org)
The 24-year-old woman, who was registered as a volunteer donor in the German Bone Marrow Donor Registry, was selected. (cdc.gov)
A second apheresis or a bone marrow collection was considered, but neither was performed because the clinical condition of the donor worsened. (cdc.gov)
eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)

The best possible match is a healthy donor who has human leukocyte antigens (HLA) that are a close match to yours. (clevelandclinic.org)
For many patients who don't have a well-matched, healthy donor, a cord blood transplant is a viable option. (mdanderson.org)

A total of 34,799 potential donors were screened and 20,710 consented. (emmes.com)
Several potential donors who match the recipient at this basic level undergo additional testing to find the best HLA match. (healthline.com)
Conduct confidential interviews with potential donors to identify high-risk behaviors. (researchgate.net)

One key factor though, Sharon said, is that the model assumes that the organ donor and the recipient are not related. (genomeweb.com)
Additionally, the goal of creating a single, standardized instrument is to increase the assurance of safe donation by: 1) optimizing identification of suitable donors, 2) minimizing donor loss due to inappropriate exclusion, 3) accurately identifying an organ donor risk designation, and 4) reducing complexity to facilitate comprehension by a bereaved interviewee. (cdc.gov)

The idea was to find the most likely proportion of cfDNA that is donor derived given the recipient genotype and cfDNA sequences by iterating over different donor ancestral populations and accounting for sequencing and genotyping errors," Sharon said. (genomeweb.com)
For those cases, we took another step and modeled the relationship between the donor and the recipient and calculated for that," Sharon said. (genomeweb.com)
The statistical models help estimate the proportion of cfDNA fragments that are from the recipient and donor. (genomeweb.com)
The researchers compared their so-called one-genome model to the two-genome method, where both donor and recipient genotypes are known. (genomeweb.com)
They found that the statistical model was able to learn the relationship between the donor and recipient and that the one-genome method was comparable to the two-genome method. (genomeweb.com)
Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
However, the donor was unable to postpone her trip, and the recipient was in urgent need of the transplant. (cdc.gov)
After being informed about possible infection of the donor, the transplant physicians administered immunoglobulin to the recipient intravenously. (cdc.gov)

The study proposes the use of Fludarabine, Busulfan, Anti Thymocyte Globulin Rabbit (ATG) and Total Body Irradiation as a preparative regimen before hematopoietic stem cell transplant from unrelated donor peripheral blood stem cells (PBSC). (mycancergenome.org)

You have a donor whose human leukocyte antigens (HLA) closely match yours. (clevelandclinic.org)
[10] It is less common in younger patients and in those with closer human leukocyte antigens (HLA) matches between donor and the patient. (wikipedia.org)

Most organ and tissue donations occur after the donor has died. (medlineplus.gov)
Through our collaborations and discussions with clinicians, we learned that in many cases it's difficult for clinicians to get a hold of a tissue sample from the donor," De Vlaminck said. (genomeweb.com)
Health Canada proposes to make NAT a requirement instead of a recommendation for the detection of human immunodeficiency virus type 1 ( HIV -1) and Hepatitis C ( HCV ) for tissue donation from deceased donors, as well as for cord blood donation. (canada.ca)
The DRAI project began in early 2006 with the purpose of creating a uniform donor history questionnaire for organ, tissue, and ocular donation organizations and professional associations in the United States. (cdc.gov)

In high-income countries, match sibling donor (MSD) and match unrelated donor (MUD) HSCT have similar outcomes, but data are scarce in upper-middle-income countries. (ox.ac.uk)

Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
An important barrier to HSCT has been the inability to secure a suitable donors. (medscape.com)
Since many of these patients lack HLA-identical sibling donors and are older or have comorbidity, a fully ablative HSCT is not feasible and an alternative approach is required. (nih.gov)
Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)

At least 2 unrelated donors noted on NMDP search who are well matched (9/10 or 10/10 for HLA-A, B, C, DRB1, and DQB1 using high resolution). (ucsf.edu)

No suitable fully matched related donor available (minimum 6/6 match for HLA-A and B at intermediate or high resolution and DRB1 at high resolution using DNA based typing). (ucsf.edu)
Most of those people - about 70% - do not have a suitable donor in their family and must find a match through a voluntary registry, like Be The Match . (healthline.com)
It can also happen through voluntary registries that seek suitable donors for people in need of a transplant. (healthline.com)

But some organs and tissues can be donated while the donor is alive. (medlineplus.gov)

It established the future use of unrelated donors to patients, so far for over 10,000 people. (wikipedia.org)
A nonmyeloablative conditioning regimen was investigated in 47 patients with hematological malignancy receiving allogeneic progenitor cells from matched, unrelated donors. (ox.ac.uk)
Chimerism studies in 34 patients indicated that the majority (85.3%) attained initial full donor chimerism. (ox.ac.uk)
The sum of ranks of the haplotypes carried by patients was used as a surrogate predictor of a successful unrelated donor search. (unige.ch)
Patients without a matched family donor normally are treated with immune suppressive therapy (IST). (ucsf.edu)
Many patients find matched unrelated donors through the National Marrow Donor Program. (mdanderson.org)
Molecular analysis of X-linked chronic granulomatous disease in five unrelated Korean patients. (medscape.com)
Because only one fourth of patients have such a sibling donor, mismatched related or matched unrelated donors (identified through international registries) are often used. (msdmanuals.com)

We try to find a donor who has 10 antigens that match 10 of the patient's antigens. (mdanderson.org)
If the donor cells aren't a close enough match, the patient's body may recognize the donor cells as foreign and reject them. (mdanderson.org)
The main risk still remains the "graft-versus-host reaction", in which donor cells attack the patient's own cells, which are foreign to them. (disabled-world.com)

We examined the factors influencing the high survival rates of spousal-donor kidneys. (nih.gov)
The superior survival rate of grafts from unrelated donors could not be attributed to better HLA matching, white race, younger donor age, or shorter cold-ischemia times, but might be explained by damage due to shock before removal in 10 percent of the cadaveric kidneys. (nih.gov)
Spouses are an important source of living-donor kidney grafts because, despite poor HLA matching, the graft-survival rate is similar to that of parental-donor kidneys. (nih.gov)

Outcomes with Mismatched Unrelated Donor Allogeneic Hematopoietic Stem" by Moazzam Shahzad, Sibgha Gull Chaudhary et al. (lvhn.org)

It is crucial that people understand the importance of organ donation and choose to be a donor irrespective of whether the organ saves the life of their family member, friend or an unrelated individual. (gulfnews.com)
Laboratory testing is one method for detecting infectious disease and understanding expected organ function, however, laboratory tests cannot detect all aspects of infection and donation quality, and gaps that remain can be addressed by collecting accurate information from a proxy (or proxies) providing information on behalf of the deceased donor. (cdc.gov)
and recall of stored tissues from donors found after donation to have been infected. (cdc.gov)

Iwijn De Vlaminck, an assistant professor of biomedical engineering at Cornell and senior author of the study, said that previous work had identified that donor-derived cell-free DNA is a "good marker of transplant rejection" because increased levels of donor cfDNA indicates more damage to the graft and thus, rejection. (genomeweb.com)

The Network for Pancreatic Organ donors with Diabetes (nPOD) is the largest biorepository of human pancreata and associated immune organs from donors with type 1 diabetes (T1D), maturity-onset diabetes of the young (MODY), cystic fibrosis-related diabetes (CFRD), type 2 diabetes (T2D), gestational diabetes, islet autoantibody positivity (AAb+), and without diabetes. (nature.com)
The body's immune system can attack the donor stem cells. (kidshealth.org)
It is crucial to control the transplanted donor immune cells so that the effect is strong enough to eliminate the leukemia cells but not strong enough to lead to complications in other tissues and organs. (disabled-world.com)

Despite mandatory testing of donors and strict exclusion criteria to prevent transmission, risk remains for transmission of communicable diseases, including tropical diseases for which screening is not usually performed. (cdc.gov)
Exclusion of prospective blood donors based on their acknowledged risk behaviors for human immunodeficiency virus (HIV) infection began in 1983 (1). (cdc.gov)

1 fully matched unrelated female donor was identified in the German National Registry. (cdc.gov)

The heart cohort had lower levels of donor-derived cfDNA, so inferring the donor genotype was harder, the authors wrote in the study. (genomeweb.com)

The National Marrow Donor Program requires you be between 18 and 40 years old to donate. (healthline.com)

Assessing donor suitability is a multipronged approach. (cdc.gov)

Implement strict donor eligibility criteria, including assessing risk factors for TTDs such as sexual behavior, travel history, and medical history. (researchgate.net)

Data were technically validated using published algorithms to evaluate donor relatedness, ancestry, imputed HLA, and T1D genetic risk score. (nature.com)
A transplant using stem cells from a donor increases your risk for fungal infection more than a transplant that uses stem cells from your own body. (cdc.gov)

We are proud that we were able to partner in this milestone procedure between three groups of unrelated individuals that saved three lives," he added. (gulfnews.com)

The donor had scheduled a trip to Sri Lanka, and was to return 3 days before the scheduled start of granulocyte-colony-stimulating factor, or G-CSF, application. (cdc.gov)

In a little over 4,800 cases, the blood came from an unrelated donor. (healthline.com)
Standard leukopheresis processing of blood from the donor was performed without problems. (cdc.gov)
Ensure that regulatory agencies and blood transfusion services have clear guidelines and standards for donor screening, testing, and quality control. (researchgate.net)
Why is Cytomegalovirus not routinely tested among blood donors in several countries like Nigeria? (researchgate.net)
With this, why is transfusion transmissible infection (TTI) such as Cytomegalovirus not routinely tested among blood donors in several countries like Nigeria? (researchgate.net)
In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)

A human leukocyte antigen (HLA)-identical sibling donor is ideal, followed by an HLA-matched sibling donor. (msdmanuals.com)
However, long-term disease-free survival rates may be lower than those with HLA-identical sibling donors. (msdmanuals.com)

The donor had returned from her trip 3 days before the start of G-CSF-injections without any signs of infection. (cdc.gov)

It also lists evolving chal- versal guidelines has been made by the rewards and grants to donors accept- lenges and foreseeable opportunities for World Health Organization (WHO), able? (who.int)

Anatomy9

Organisms2

Diseases35

Chemicals and Drugs31

Analytical, Diagnostic and Therapeutic Techniques and Equipment57

Psychiatry and Psychology3

Phenomena and Processes27

Anthropology, Education, Sociology and Social Phenomena3

Information Science9

Named Groups6

Health Care26

Geographicals1

Transplantation24

Transplants3

Recipients7

Bone15

Healthy donor2

Potential donors3

Organ donor2

Recipient8

Peripheral blood stem cells1

Human leukocyt2

Tissue4

Match unrelated1

HSCT4

NMDP1

Suitable3

Organs and tissues1

Patients8

Patient's3

Kidneys3

Outcomes1

Donation3

Graft1

Immune3

Exclusion2

Fully matched1

Cohort1

National Marrow1

Suitability1

Eligibility1

Risk2

Procedure1

Lanka1

Blood6

Identical2

Infection1

Grants1