• toxic
  • Pharmacotoxicology entails the study of the consequences of toxic exposure to pharmaceutical drugs and agents in the health care field. (wikipedia.org)
  • activity
  • The mechanism of antineoplastic activity of mannomustine, like for all other alkylating agents, lies in its ability to alkylate DNA guanine nucleobases and, thus, to prevent uncoupling of DNA strands, which is a required step for any cell to divide. (wikipedia.org)
  • known
  • Mannomustine (INN), also known as mannitol nitrogen mustard, tradename Degranol is an old alkylating antineoplastic agent from the group of nitrogen mustards. (wikipedia.org)
  • cells
  • Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. (biomedsearch.com)
  • Consistent with this, telomerase-immortalised cells continued to age (according to the epigenetic clock) without having been treated with any senescence inducers or DNA-damaging agents, re-affirming the independence of the process of epigenetic ageing from telomeres, cellular senescence, and the DNA damage response pathway. (wikipedia.org)
  • Heterologous desensitization may occur in cells that are grossly overstimulated for prolonged times by a certain agents. (wikipedia.org)
  • taken
  • After a shootout, George and Grover jump off the train and are arrested and taken to a train station, where federal agent Donaldson explains that he planted the Stevens murder story to protect George. (wikipedia.org)
  • acts
  • Aspirin acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the active site of the COX enzyme. (wikipedia.org)