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  • receptor tyrosin
  • They inhibit tumour angiogenesis, one of the key processes leading to invasion and metastasis of solid tumours, by targeting receptor tyrosine kinases. (wikipedia.org)
  • It inhibits the following receptor tyrosine kinases: MET (hepatocyte growth factor receptor protein) and VEGFR, RET, GAS6 receptor (AXL), KIT), and Fms-like tyrosine kinase-3 (FLT3). (wikipedia.org)
  • Protein
  • The word "tyrosine" is from the Greek tyros, meaning cheese, as it was first discovered in 1846 by German chemist Justus von Liebig in the protein casein from cheese. (wikipedia.org)
  • glutamate
  • l‐tyrosine + 2‐oxoglutarate = 4‐hydroxyphenylpyruvate + l‐glutamate. (oup.com)
  • Prephenate is oxidatively decarboxylated with retention of the hydroxyl group to give p-hydroxyphenylpyruvate, which is transaminated using glutamate as the nitrogen source to give tyrosine and α-ketoglutarate. (wikipedia.org)
  • convert
  • The latex of Papaver somniferum, the opium poppy, has been shown to convert tyrosine into the alkaloid morphine and the bio-synthetic pathway has been established from tyrosine to morphine by using Carbon-14 radio-labelled tyrosine to trace the in-vivo synthetic route. (wikipedia.org)
  • This is a necessary process for any organism which needs to convert arogenate into phenylalanine or tyrosine, as arogenate is an intermediate in the reactions which synthesize these amino acids, an alternative route to that involving phenylpyruvate and hydroxyphenylpyruvate. (wikipedia.org)
  • levels
  • Tyrosinemia type II (Richner-Hanhart syndrome, RHS) is a disease of autosomal recessive inheritance characterized by keratitis, palmoplantar hyperkeratosis, mental retardation, and elevated blood tyrosine levels. (wikipedia.org)
  • Toxic levels of phenylalanine (and insufficient levels of tyrosine) can interfere with infant development in ways which have permanent effects. (wikipedia.org)
  • weight loss, elevated transaminases, higher cholesterol levels, and loss of red and white blood cells. (wikipedia.org)
  • activity
  • Tyrosine phosphorylation is considered to be one of the key steps in signal transduction and regulation of enzymatic activity. (wikipedia.org)
  • Phytochemistry 61: 121-125 Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity. (wikipedia.org)
  • complex
  • The amine group of tyrosine attacks the alpha carbon of the imine bonded to Lys280, forming a tetrahedral complex and then kicking off the LYS-ENZ. (wikipedia.org)
  • results
  • Keratitis in Tyrosinemia type II patients is caused by the deposition of tyrosine crystals in the cornea and results in corneal inflammation. (wikipedia.org)
  • FLT3
  • XOSPATA has demonstrated inhibitory activity against two different mutations, FLT3 internal tandem duplication (ITD) and FLT3 tyrosine kinase domain (TKD) .2 Impacting approximately 30 percent of AML patients, the FLT3-ITD mutation is associated with worsened disease free survival and overall survival. (astellas.com)
  • protein
  • The word "tyrosine" is from the Greek tyros, meaning cheese, as it was first discovered in 1846 by German chemist Justus von Liebig in the protein casein from cheese. (wikipedia.org)
  • alpha
  • The amine group of tyrosine attacks the alpha carbon of the imine bonded to Lys280, forming a tetrahedral complex and then kicking off the LYS-ENZ. (wikipedia.org)
  • Results
  • Keratitis in Tyrosinemia type II patients is caused by the deposition of tyrosine crystals in the cornea and results in corneal inflammation. (wikipedia.org)
  • cell
  • Sublethal hepatocyte damage induces pro-inflammatory cytokine release, whereas harsher insults cause cell necrosis detectable as rupture of transaminases into the bloodstream. (aacrjournals.org)